Neuropeptide Y: An Endogenous Inhibitor of Norepinephrine-Stimulated Melatonin Secretion in the Rat Pineal Gland

1991 ◽  
Vol 57 (3) ◽  
pp. 943-947 ◽  
Author(s):  
James Olcese
Keyword(s):  
Pineal Gland ◽  
Neuropeptide Y ◽  
Endogenous Inhibitor ◽  
Melatonin Secretion ◽  
Rat Pineal Gland

CircRNA-WNK2 acts as a ceRNA for miR-328a-3p to promote AANAT expression in the male rat pineal gland

Endocrinology ◽  
2021 ◽  
Author(s):  
Yi Zheng ◽  
Hao-Qi Wang ◽  
Hai-Xiang Guo ◽  
Heng-Li Xie ◽  
Wei-Di Zhang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Circadian Rhythm ◽  
Pineal Gland ◽  
Rat Model ◽  
Noncoding Rnas ◽  
Luciferase Reporter ◽  
Male Rat ◽  
Biological Functions ◽  
Melatonin Secretion ◽  
Rat Pineal Gland

Abstract Noncoding RNAs (ncRNAs), including miRNAs and circRNAs, which are expressed with a daily rhythm in the rat pineal gland, are associated with the regulation of melatonin secretion and other biological functions. However, the mechanisms of these molecules in the rat pineal gland are not yet fully understood. In this study, we found circR-WNK2 was highly expressed at night, which may be involved in the regulation of melatonin secretion through the ceRNA mechanism. By dual luciferase reporter, RNA pulldown, and FISH assays, we found that miR-328a-3p can target circR-WNK2 and the Aa-nat mRNA 3’UTR. Transfection experiments indicated that circR-WNK2 could competitively bind to miR-328a-3p, reduce miR-328a-3p expression, and promote Aa-nat gene expression and melatonin secretion. And by constructing an SCGx rat model, we found that ncRNAs expressed in the pineal gland was regulated by signals from the SCN. This finding supports the hypothesis that these noncoding RNAs may interact to shape the circadian rhythm through transcriptional processing in melatonin synthesis.

Adrenergic and Peptidergic Control of the Regulation of cAMP Efflux and Melatonin Secretion from Perifused Rat Pineal Gland

Endocrine ◽  
1998 ◽  
Vol 9 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Zoltan Rekasi ◽  
Norbert Sule ◽  
Valer Csernus ◽  
Bela Mess
Keyword(s):  
Pineal Gland ◽  
Melatonin Secretion ◽  
Rat Pineal Gland

Presynaptic and postsynaptic effects of neuropeptide Y in the rat pineal gland

Neuropeptides ◽  
1994 ◽  
Vol 26 ◽  
pp. 16
Author(s):  
V. Simonncaux ◽  
A. Ouichou ◽  
P. Pévet
Keyword(s):  
Pineal Gland ◽  
Neuropeptide Y ◽  
Rat Pineal Gland

Circadian variations of neuropeptide Y-like immunoreactivity in the rat pineal gland

Neuroreport ◽  
1994 ◽  
Vol 5 (10) ◽  
pp. 1262-1264 ◽  
Author(s):  
Kazuyuki Shinohara ◽  
Shin-ichi T. Inouye
Keyword(s):  
Pineal Gland ◽  
Neuropeptide Y ◽  
Circadian Variations ◽  
Rat Pineal Gland

In vitro effect of neuropeptide Y on melatonin and norepinephrine release in rat pineal gland

1987 ◽  
Vol 7 (3) ◽  
pp. 309-315 ◽  
Author(s):  
Mar�a I. Vacas ◽  
Mar�a I. Keller Sarmiento ◽  
Elba N. Pereyra ◽  
Graciela S. Etchegoyen ◽  
Daniel P. Cardinali
Keyword(s):  
Pineal Gland ◽  
Neuropeptide Y ◽  
Norepinephrine Release ◽  
Vitro Effect ◽  
Rat Pineal Gland

Presynaptic and Postsynaptic Effects of Neuropeptide Y in the Rat Pineal Gland

2008 ◽  
Vol 62 (6) ◽  
pp. 2464-2471 ◽  
Author(s):  
Valérie Simonneaux ◽  
AH Ouichou ◽  
Cheryl Craft ◽  
Paul Pévet
Keyword(s):  
Pineal Gland ◽  
Neuropeptide Y ◽  
Rat Pineal Gland

Circadian Variation of Cyclic AMP in the Rat Pineal Gland

1981 ◽  
Vol 36 (3) ◽  
pp. 1295-1297 ◽  
Author(s):  
Masahiko Mikuni ◽  
Yoshiro Saito ◽  
Tsukasa Koyama ◽  
Itaru Yamashita
Keyword(s):  
Cyclic Amp ◽  
Pineal Gland ◽  
Circadian Variation ◽  
Rat Pineal Gland

Daily rhythm and regulation of clock gene expression in the rat pineal gland

2004 ◽  
Vol 120 (2) ◽  
pp. 164-172 ◽  
Author(s):  
V Simonneaux ◽  
V.-J Poirel ◽  
M.-L Garidou ◽  
D Nguyen ◽  
E Diaz-Rodriguez ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pineal Gland ◽  
Clock Gene ◽  
Daily Rhythm ◽  
Clock Gene Expression ◽  
Rat Pineal Gland
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