Daily rhythm and regulation of clock gene expression in the rat pineal gland

2004 ◽  
Vol 120 (2) ◽  
pp. 164-172 ◽  
Author(s):  
V Simonneaux ◽  
V.-J Poirel ◽  
M.-L Garidou ◽  
D Nguyen ◽  
E Diaz-Rodriguez ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pineal Gland ◽  
Clock Gene ◽  
Daily Rhythm ◽  
Clock Gene Expression ◽  
Rat Pineal Gland

scholarly journals Chronic treatment with dexamethasone alters clock gene expression and melatonin synthesis in rat pineal gland at night

2018 ◽  
Vol Volume 10 ◽  
pp. 203-215 ◽  
Author(s):  
Daniela Meneses-Santos ◽  
Daniella do Carmo Buonfiglio ◽  
Rodrigo Antonio Peliciari-Garcia ◽  
Angela Maria Ramos-Lobo ◽  
Divanízia do Nascimento Souza ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pineal Gland ◽  
Clock Gene ◽  
Chronic Treatment ◽  
Melatonin Synthesis ◽  
Clock Gene Expression ◽  
Rat Pineal Gland

Daily rhythms in clock gene expression in the mouse pineal gland

2003 ◽  
Vol 2003 (Spring) ◽  
Author(s):  
Magdalena Karolczak ◽  
Guido J. Burbach ◽  
Horst-Werner Korf ◽  
Jörg H. Stehle
Keyword(s):  
Gene Expression ◽  
Pineal Gland ◽  
Clock Gene ◽  
Daily Rhythms ◽  
Clock Gene Expression

A genetic CLOCK variant associated with cluster headache causing increased mRNA levels

Cephalalgia ◽  
2017 ◽  
Vol 38 (3) ◽  
pp. 496-502 ◽  
Author(s):  
Carmen Fourier ◽  
Caroline Ran ◽  
Margret Zinnegger ◽  
Anne-Sofie Johansson ◽  
Christina Sjöstrand ◽  
...  
Keyword(s):  
Gene Expression ◽  
Circadian Rhythm ◽  
Cluster Headache ◽  
Clock Gene ◽  
Control Sample ◽  
Mrna Levels ◽  
Nucleotide Polymorphisms ◽  
Primary Fibroblast ◽  
Clock Gene Expression ◽  
Diurnal Preference

Background Cluster headache is characterized by recurrent unilateral headache attacks of severe intensity. One of the main features in a majority of patients is a striking rhythmicity of attacks. The CLOCK ( Circadian Locomotor Output Cycles Kaput) gene encodes a transcription factor that serves as a basic driving force for circadian rhythm in humans and is therefore particularly interesting as a candidate gene for cluster headache. Methods We performed an association study on a large Swedish cluster headache case-control sample (449 patients and 677 controls) screening for three single nucleotide polymorphisms (SNPs) in the CLOCK gene implicated in diurnal preference (rs1801260) or sleep duration (rs11932595 and rs12649507), respectively. We further wanted to investigate the effect of identified associated SNPs on CLOCK gene expression. Results We found a significant association with rs12649507 and cluster headache ( p = 0.0069) and this data was strengthened when stratifying for reported diurnal rhythmicity of attacks ( p = 0.0009). We investigated the effect of rs12649507 on CLOCK gene expression in human primary fibroblast cultures and identified a significant increase in CLOCK mRNA expression ( p = 0.0232). Conclusions Our results strengthen the hypothesis of the involvement of circadian rhythm in cluster headache.

scholarly journals Circadian Clock Gene Expression in the Coral Favia fragum over Diel and Lunar Reproductive Cycles

PLoS ONE ◽  
2011 ◽  
Vol 6 (5) ◽  
pp. e19755 ◽  
Author(s):  
Kenneth D. Hoadley ◽  
Alina M. Szmant ◽  
Sonja J. Pyott
Keyword(s):  
Gene Expression ◽  
Circadian Clock ◽  
Clock Gene ◽  
Circadian Clock Gene ◽  
Clock Gene Expression ◽  
Favia Fragum ◽  
Reproductive Cycles

Modelling the functional roles of synaptic and extra-synaptic γ-aminobutyric acid receptor dynamics in circadian timekeeping

2021 ◽  
Vol 18 (182) ◽  
pp. 20210454
Author(s):  
Natthapong Sueviriyapan ◽  
Daniel Granados-Fuentes ◽  
Tatiana Simon ◽  
Erik D. Herzog ◽  
Michael A. Henson
Keyword(s):  
Gene Expression ◽  
Clock Gene ◽  
Aminobutyric Acid ◽  
Receptor Density ◽  
Gamma Subunit ◽  
Functional Roles ◽  
Clock Gene Expression ◽  
Receptor Dynamics ◽  
Delta Subunit ◽  
Phase Relationships

In the suprachiasmatic nucleus (SCN), γ-aminobutyric acid (GABA) is a primary neurotransmitter. GABA can signal through two types of GABA A receptor subunits, often referred to as synaptic GABA A (gamma subunit) and extra-synaptic GABA A (delta subunit). To test the functional roles of these distinct GABA A in regulating circadian rhythms, we developed a multicellular SCN model where we could separately compare the effects of manipulating GABA neurotransmitter or receptor dynamics. Our model predicted that blocking GABA signalling modestly increased synchrony among circadian cells, consistent with published SCN pharmacology. Conversely, the model predicted that lowering GABA A receptor density reduced firing rate, circadian cell fraction, amplitude and synchrony among individual neurons. When we tested these predictions, we found that the knockdown of delta GABA A reduced the amplitude and synchrony of clock gene expression among cells in SCN explants. The model further predicted that increasing gamma GABA A densities could enhance synchrony, as opposed to increasing delta GABA A densities. Overall, our model reveals how blocking GABA A receptors can modestly increase synchrony, while increasing the relative density of gamma over delta subunits can dramatically increase synchrony. We hypothesize that increased gamma GABA A density in the winter could underlie the tighter phase relationships among SCN cells.

scholarly journals Effect of Quetiapine on Per1, Per2, and Bmal1 Clock Gene Expression in the Mouse Amygdala and Hippocampus

2014 ◽  
Vol 125 (3) ◽  
pp. 329-332 ◽  
Author(s):  
Shunpei Moriya ◽  
Yu Tahara ◽  
Hiroyuki Sasaki ◽  
Yutaro Hamaguchi ◽  
Daisuke Kuriki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Clock Gene ◽  
Clock Gene Expression

scholarly journals Correction to: Low-Grade Inflammation Aggravates Rotenone Neurotoxicity and Disrupts Circadian Clock Gene Expression in Rats

2018 ◽  
Vol 35 (4) ◽  
pp. 999-1000 ◽  
Author(s):  
Huan Li ◽  
Sheng Song ◽  
Yuan Wang ◽  
Chun Huang ◽  
Feng Zhang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Circadian Clock ◽  
Clock Gene ◽  
Low Grade ◽  
Circadian Clock Gene ◽  
Clock Gene Expression ◽  
Low Grade Inflammation
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