scholarly journals Sustained pharmacological blockade of NK1 substance P receptors causes functional desensitization of dorsal raphe 5-HT1A autoreceptors in mice

2005 ◽  
Vol 95 (6) ◽  
pp. 1713-1723 ◽  
Author(s):  
Bruno P. Guiard ◽  
Nicolas Froger ◽  
Michel Hamon ◽  
Alain M. Gardier ◽  
Laurence Lanfumey
Keyword(s):  
Substance P ◽  
Dorsal Raphe ◽  
Pharmacological Blockade ◽  
Dorsal Raphé ◽  
Substance P Receptors

Serotonin and substance P co-exist in dorsal raphe neurons of the human brain

Neuroreport ◽  
1999 ◽  
Vol 10 (18) ◽  
pp. 3967-3970 ◽  
Author(s):  
Valeriy Sergeyev ◽  
Tomas Hökfelt ◽  
Yasmin Hurd
Keyword(s):  
Substance P ◽  
Human Brain ◽  
Dorsal Raphe ◽  
Dorsal Raphé ◽  
Raphe Neurons

Trafficking of neurokinin-1 receptors in serotonin neurons is controlled by substance P within the rat dorsal raphe nucleus

2009 ◽  
Vol 29 (12) ◽  
pp. 2303-2314 ◽  
Author(s):  
Baptiste Lacoste ◽  
Mustapha Riad ◽  
Marc-Olivier Ratté ◽  
Sandra M. Boye ◽  
Daniel Lévesque ◽  
...  
Keyword(s):  
Substance P ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Serotonin Neurons ◽  
Neurokinin 1 ◽  
Dorsal Raphé

scholarly journals Substance P (Neurokinin 1) Receptor Antagonists Enhance Dorsal Raphe Neuronal Activity

2002 ◽  
Vol 22 (17) ◽  
pp. 7730-7736 ◽  
Author(s):  
Rachel K. Conley ◽  
Michael J. Cumberbatch ◽  
Glenn S. Mason ◽  
David J. Williamson ◽  
Timothy Harrison ◽  
...  
Keyword(s):  
Substance P ◽  
Neuronal Activity ◽  
Dorsal Raphe ◽  
Receptor Antagonists ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1 ◽  
Dorsal Raphé

scholarly journals Inter- and intracellular relationship of substance P-containing neurons with serotonin and GABA in the dorsal raphe nucleus: combination of autoradiographic and immunocytochemical techniques.

1986 ◽  
Vol 34 (6) ◽  
pp. 735-742 ◽  
Author(s):  
R Mâgoul ◽  
B Onteniente ◽  
A Oblin ◽  
A Calas
Keyword(s):  
Substance P ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Electron Microscopic Level ◽  
Gamma Aminobutyric Acid ◽  
Electron Microscopic ◽  
Double Labeling ◽  
Relationship Of ◽  
Dorsal Raphé

Double-labeling experiments were performed at the electron microscopic level in the dorsal raphe nucleus of rat, in order to study the inter- and intracellular relationship of substance P with gamma-aminobutyric acid (GABA) and serotonin. Autoradiography for either [3H]serotonin or [3H]GABA was coupled, on the same tissue section, with peroxidase-antiperoxidase immunocytochemistry for substance P in colchicine-treated animals. Intercellular relationships were represented by synaptic contacts made by [3H]serotonin-labeled terminals on substance P-containing somata and dendrites, and by substance P-containing terminals on [3H]GABA-labeled cells. Intracellular relationships were suggested by the occurrence of the peptide within [3H]serotonin-containing and [3H]GABA-containing cell bodies and fibers. Doubly labeled varicosities of the two kinds were also observed in the supraependymal plexus adjacent to the dorsal raphe nucleus. The results demonstrated that, in addition to reciprocal synaptic interactions made by substance P with serotonin and GABA, the dorsal raphe nucleus is the site of intracellular relationships between the peptide and either the amine or the amino acid.

Distribution, morphology and number of monoamine-synthesizing and substance P-containing neurons in the human dorsal raphe nucleus

Neuroscience ◽  
1991 ◽  
Vol 42 (3) ◽  
pp. 757-775 ◽  
Author(s):  
K.G. Baker ◽  
G.M. Halliday ◽  
J.-P. Hornung ◽  
L.B. Geffen ◽  
R.G.H. Cotton ◽  
...  
Keyword(s):  
Substance P ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Dorsal Raphé
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