scholarly journals The effects of central myorelaxants on synaptically-evoked primary afferent depolarization in the immature rat spinal cord in vitro

1994 ◽  
Vol 111 (2) ◽  
pp. 497-502 ◽  
Author(s):  
R. J. Siarey ◽  
S.K. Long ◽  
M.T.H. Tulp ◽  
R.H. Evans
Keyword(s):  
Spinal Cord ◽  
Primary Afferent Depolarization ◽  
Rat Spinal Cord ◽  
Primary Afferent ◽  
Immature Rat

scholarly journals The effect of nicotine on motoneurones of the immature rat spinal cord in vitro

1987 ◽  
Vol 90 (1) ◽  
pp. 167-173 ◽  
Author(s):  
J.F. Blake ◽  
R.H. Evans ◽  
D.A.S. Smith
Keyword(s):  
Spinal Cord ◽  
Rat Spinal Cord ◽  
Immature Rat

α5GABAA receptors mediate primary afferent fiber tonic excitability in the turtle spinal cord

2013 ◽  
Vol 110 (9) ◽  
pp. 2175-2184 ◽  
Author(s):  
Emanuel Loeza-Alcocer ◽  
Martha Canto-Bustos ◽  
Justo Aguilar ◽  
Ricardo González-Ramírez ◽  
Ricardo Felix ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Afferent Fiber ◽  
Primary Afferents ◽  
Equilibrium Potential ◽  
Primary Afferent Depolarization ◽  
Primary Afferent ◽  
Dorsal Root Reflex

γ-Amino butyric acid (GABA) plays a key role in the regulation of central nervous system by activating synaptic and extrasynaptic GABAA receptors. It is acknowledged that extrasynaptic GABAA receptors located in the soma, dendrites, and axons may be activated tonically by low extracellular GABA concentrations. The activation of these receptors produces a persistent conductance that can hyperpolarize or depolarize nerve cells depending on the Cl− equilibrium potential. In an in vitro preparation of the turtle spinal cord we show that extrasynaptic α5GABAA receptors mediate the tonic state of excitability of primary afferents independently of the phasic primary afferent depolarization mediated by synaptic GABAA receptors. Blockade of α5GABAA receptors with the inverse agonist L-655,708 depressed the dorsal root reflex (DRR) without affecting the phasic increase in excitability of primary afferents. Using RT-PCR and Western blotting, we corroborated the presence of the mRNA and the α5GABAA protein in the dorsal root ganglia of the turtle spinal cord. The receptors were localized in primary afferents in dorsal root, dorsal root ganglia, and peripheral nerve terminals using immunoconfocal microscopy. Considering the implications of the DRR in neurogenic inflammation, α5GABAA receptors may serve as potential pharmacological targets for the treatment of pain.

Effect of chronic undernourishment on the cord dorsum potentials and the primary afferent depolarization evoked by cutaneous nerves in the rat spinal cord

2011 ◽  
Vol 85 (1-2) ◽  
pp. 68-74 ◽  
Author(s):  
Salvador Quiróz González ◽  
Bertha Segura Alegría ◽  
José Carlos Guadarrama Olmos ◽  
Ismael Jiménez-Estrada
Keyword(s):  
Spinal Cord ◽  
Primary Afferent Depolarization ◽  
Rat Spinal Cord ◽  
Primary Afferent

scholarly journals A comparison of the actions of agonists and antagonists at non-NMDA receptors of C fibres and motoneurones of the immature rat spinal cord in vitro

1993 ◽  
Vol 108 (1) ◽  
pp. 179-184 ◽  
Author(s):  
P. Pook ◽  
F. Brugger ◽  
N.S. Hawkins ◽  
K.C. Clark ◽  
J.C. Watkins ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Nmda Receptors ◽  
Rat Spinal Cord ◽  
Immature Rat
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