Liver transplantation and quality of life: relevance of a specific liver disease questionnaire

2007 ◽  
Vol 28 (1) ◽  
pp. 99-106 ◽  
Author(s):  
Daniela R. M. Gotardo ◽  
Edna Strauss ◽  
Maria-Cristina D. Teixeira ◽  
Marcel C. C. Machado
2018 ◽  
Vol 29 (1) ◽  
pp. 61-66
Author(s):  
Marianna Yumi Kawashima Vasconcelos ◽  
Ana Rafaela Felippini Lopes ◽  
Ênio David Mente ◽  
Orlando Castro-e-Silva ◽  
Cristina Maria Galvão ◽  
...  

Introduction: The advanced stage of liver disease causes impairments in the quality of life due to the physiological symptoms, besides the social and emotional stress. The aim of this study was to evaluate the quality of life of candidates for liver transplantation in specialized center in the interior of the state of São Paulo, Brazil. Methods: An observational study was carried out, with a quantitative approach. The sample was of convenience with the participation of 50 candidates for liver transplantation. Demographic characterization data, clinical data, and the Chronic Liver Disease Questionnaire were used to evaluate the quality of life. Results: The majority of the participants were male (68%), married (76%), with an average age of 55.7 years and average income of 2 to 3 minimum wages (42%). The main cause of liver disease was alcoholism (34%), mean time on the waiting list was 247.8 days, and mean model for end-stage liver disease was 20.5 points. The mean quality of life score was 2.9 points (standard deviation = 1.0) and the analysis of the 6 domains showed greater impairment of fatigue (2.2), activity (2.7), and concern (2.9) and better evaluation of systemic symptoms (3.4) and emotion (3.3). Conclusion: Quality of life is impaired in most of the participants, indicating the need for greater attention and evaluation in the physical, mental, and social scope of this clientele.


2021 ◽  
Vol 15 (1) ◽  
pp. 196-203
Author(s):  
Larissa S. Santos-Lins ◽  
Inácio L.S. Aguiar ◽  
Liana Codes ◽  
Maria A. Evangelista ◽  
Alessandra de Oliveira Castro ◽  
...  

Background: Oral health is associated with Chronic Liver Disease (CLD) and may play a relevant role in oral (OHRQoL) and general health-related quality of life (HRQoL) among people with chronic liver disease (CLD). Objective: To explore the correlations between OHRQoL and HRQoL in pre- and post-liver transplantation (LT) patients. Methods: A cross-sectional study with 189 patients: 63 per group (pre-LT, post-LT, and without liver disease). The Oral Health Impact Profile-14 (OHIP-14), the 36-Item Short-Form Health Survey, and the Work Ability Index (WAI) were used to measure oral health-related quality of life, health-related quality of life, and work ability, respectively. Oral health was evaluated according to the World Health Organization criteria. The relationship between the OHIP-14 and independent variables was analysed by multiple linear regression. Results: Pre-LT group presented the highest OHIP-14 total mean score, followed by the post-LT group, compared to the group without liver disease (p=0.001). All HRQoL and WAI mean scores were lower in the pre-LT group than in the other groups (p≤0.013). In the pre-LT group, the OHIP-14 total mean score was negatively correlated with the Mental Health, Physical Functioning, and General Health mean scores (p=0.01) and negatively and significantly (p<0.05) associated with decayed teeth and with poor workability. In the post-TL group, OHRQOL of life was associated with decayed and missing teeth, lower educational level, and poor workability. Conclusion: Patients in the pre- and post-LT groups presented poorer OHRQoL compared to patients without liver disease. OHRQoL was strongly correlated with HRQoL in the pre-LT group.


2011 ◽  
Vol 21 (3) ◽  
pp. 207-214 ◽  
Author(s):  
James R. Rodrigue ◽  
David R. Nelson ◽  
Alan I. Reed ◽  
Douglas W. Hanto ◽  
Michael P. Curry

2018 ◽  
Vol 28 (1) ◽  
pp. 48-54
Author(s):  
Hiang Keat Tan ◽  
Yean Lee ◽  
Pei Yuh Chia ◽  
Shaik Hussain Nurshifa ◽  
Travis Kim Chye Tan ◽  
...  

Background: Patients with chronic liver disease often suffer from poor quality of life. The Chronic Liver Disease Questionnaire (CLDQ) is a validated tool to assess health-related quality of life in these patients. It has been translated and validated for use in many countries and languages globally. Objectives: We aimed to translate Mainland Chinese Mandarin to Singapore Mandarin and perform cross-cultural adaption of CLDQ for the Mandarin-speaking population in Singapore (CLDQ-SG). Methods: This study was conducted based on the International Society for Pharmacoeconomics and Outcomes Research Principles of Good Practice. The study consisted of two parts: part one involved cognitive debriefing and cultural adaption of CLDQ, and part two was a pilot study on the first version of CLDQ-SG among adult patients with chronic liver disease in a tertiary hospital. Results: During the cognitive debriefing process of part one, questions beginning with “recent” (最近) two weeks in Mandarin were changed to “last” (在过去) two weeks. Eighteen patients were recruited for part two of the study (50% male, mean age 49±13 years). Time taken to complete CLDQ-SG was 15±8 minutes, and the mean score was 5.1±0.5. The reliability of measurements for all domains was good, with an intra-class correlation coefficient ≥0.8. Items one and four needed further restructuring. There were no discrepancies between CLDQ and CLDQ-SG. Conclusion: This study showed that CLDQ-SG was culturally acceptable by the Mandarin-speaking population in Singapore. There were only two items that needed revision in the finalized CLDQ-SG.


Hepatology ◽  
1999 ◽  
Vol 29 (2) ◽  
pp. 356-364 ◽  
Author(s):  
Cynthia R. Gross ◽  
Michael Malinchoc ◽  
W. Ray Kim ◽  
Roger W. Evans ◽  
Russell H. Wiesner ◽  
...  

Author(s):  
Gideon M. Hirschfield ◽  
Michael E.D. Allison ◽  
Graeme J.M. Alexander

Liver transplantation is considered for patients with liver disease that is predicted to shorten life or causes symptoms that preclude an acceptable quality of life and for individuals with life-shortening genetic disease that can be cured by transplantation. One-year survival exceeds 90%, 5-year survival approaches 80%, and individual median survivals exceed 20 years....


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