Surgical Treatment of an Early Epileptic Encephalopathy with Suppression-Bursts and Focal Cortical Dysplasia

This chapter reviews the application of intracranial EEG monitoring and cortical stimulation in the surgical treatment of tuberous sclerosis (TS) patients with uncontrolled epilepsy. It begins with a review of issues related to seizure localization and determination of epileptogenic tubers, followed by a review of surgical series in which intraoperative electrocorticography (ECoG) or extraoperative EEG monitoring with subdural or depth electrodes was utilized. Specific interictal and ictal EEG patterns suggesting intrinsic epileptogenicity of tubers are described, and similarities with focal cortical dysplasia are emphasized. The discussion is illustrated with examples of invasive EEG findings in patients with TS, and their relationship to the centre and rims of epileptogenic and non-epileptogenic tubers, and to perituberal and remote cortex. The chapter provides a comprehensive resource that will help epileptologists and neurophysiologists to decide on the need for invasive EEG, and the significance of findings, in TS patients with uncontrolled epilepsy.

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Surgical treatment of pediatric focal cortical dysplasia

Neurology ◽

10.1212/wnl.0000000000003042 ◽

2016 ◽

Vol 87 (9) ◽

pp. 945-951 ◽

Cited By ~ 16

Author(s):

Hye Eun Kwon ◽

Soyong Eom ◽

Hoon-Chul Kang ◽

Joon Soo Lee ◽

Se Hoon Kim ◽

...

Keyword(s):

Surgical Treatment ◽

Focal Cortical Dysplasia ◽

Cortical Dysplasia

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Focal cortical dysplasia: long term seizure outcome after surgical treatment

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp.2006.105361 ◽

2007 ◽

Vol 78 (8) ◽

pp. 853-856 ◽

Cited By ~ 56

Author(s):

T Kral ◽

M von Lehe ◽

M Podlogar ◽

H Clusmann ◽

P Sussmann ◽

...

Keyword(s):

Surgical Treatment ◽

Focal Cortical Dysplasia ◽

Cortical Dysplasia ◽

Seizure Outcome

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Presurgical non-invasive diagnosis of focal cortical dysplasia

Epilepsia and paroxyzmal conditions ◽

10.17749/2077-8333.2018.10.4.061-071 ◽

2019 ◽

Vol 10 (4) ◽

pp. 61-71

Author(s):

S. V. Mirkhaydarov

Keyword(s):

Drug Resistance ◽

Surgical Treatment ◽

Focal Cortical Dysplasia ◽

Morphological Characteristics ◽

Cortical Dysplasia ◽

Drug Resistant ◽

Non Invasive ◽

Treatment Of Epilepsy ◽

Resistant Form ◽

Patients With Epilepsy

In recent decades, MRI increased the success rate of the diagnosis and surgical treatment of epilepsy. Approximately 30% of patients with epilepsy suffer from the drug-resistant form of this disease. Focal cortical dysplasia is the most common abnormality of cortical development that is often associated with drug-resistance. Surgery has an important role in the treatment of epilepsy caused by focal cortical dysplasia. Focal cortical dysplasia is classified by its morphological characteristics. By large, focal cortical dysplasia can be diagnosed using the up-to-date neuroimaging tools. The aim of that paper is to review the methods available for the diagnosis of focal cortical dysplasia.

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