Membrane autoantibodies in systemic lupus erythematosus: a case of autoimmune hemolytic anemia, antiphospholipid antibodies, and transient acquired activated protein C resistance

Transfusion ◽  
2008 ◽  
Vol 48 (11) ◽  
pp. 2435-2441 ◽  
Author(s):  
John F. Staropoli ◽  
Elizabeth M. Van Cott ◽  
Robert S. Makar
2009 ◽  
Vol 53 (3) ◽  
pp. 188-189 ◽  
Author(s):  
Juzo Matsuda ◽  
Kengo Gohchi ◽  
Miyo Tsukamoto ◽  
Moritaka Gotoh ◽  
Noriko Saitoh ◽  
...  

Blood ◽  
2001 ◽  
Vol 97 (4) ◽  
pp. 844-849 ◽  
Author(s):  
Christoph Male ◽  
Lesley Mitchell ◽  
James Julian ◽  
Patricia Vegh ◽  
Penny Joshua ◽  
...  

Abstract Acquired activated protein C resistance (APCR) has been hypothesized as a possible mechanism by which antiphospholipid antibodies (APLAs) cause thrombotic events (TEs). However, available evidence for an association of acquired APCR with APLAs is limited. More importantly, an association of acquired APCR with TEs has not been demonstrated. The objective of the study was to determine, in pediatric patients with systemic lupus erythematosus (SLE), whether (1) acquired APCR is associated with the presence of APLAs, (2) APCR is associated with TEs, and (3) there is an interaction between APCR and APLAs in association with TEs. A cross-sectional cohort study of 59 consecutive, nonselected children with SLE was conducted. Primary clinical outcomes were symptomatic TEs, confirmed by objective radiographic tests. Laboratory testing included lupus anticoagulants (LAs), anticardiolipin antibodies (ACLAs), APC ratio, protein S, protein C, and factor V Leiden. The results revealed that TEs occurred in 10 (17%) of 59 patients. Acquired APCR was present in 18 (31%) of 58 patients. Acquired APCR was significantly associated with the presence of LAs but not ACLAs. Acquired APCR was also significantly associated with TEs. There was significant interaction between APCR and LAs in the association with TEs. Presence of both APCR and LAs was associated with the highest risk of a TE. Protein S and protein C concentrations were not associated with the presence of APLAs, APCR, or TEs. Presence of acquired APCR is a marker identifying LA-positive patients at high risk of TEs. Acquired APCR may reflect interference of LAs with the protein C pathway that may represent a mechanism of LA-associated TEs.


2009 ◽  
Vol 124 (1) ◽  
pp. 127-131 ◽  
Author(s):  
Junzo Nojima ◽  
Yoshinori Iwatani ◽  
Kiyoshi Ichihara ◽  
Hidehiro Tsuneoka ◽  
Toshizo Ishikawa ◽  
...  

Lupus ◽  
2002 ◽  
Vol 11 (11) ◽  
pp. 730-735 ◽  
Author(s):  
F-J Muñoz-Rodríguez ◽  
J-C Reverter ◽  
J Font ◽  
D Tàssies ◽  
G Espinosa ◽  
...  

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