Serum Ferritin in Non-Dialysis Patients with Chronic Renal Failure: Relation to Bone Marrow Iron Stores

Abstract Immunoradiometric analysis has made it possible to measure ferritin reliably in serum. The determination is a sensitive means of assessing body iron because concentrations of ferritin closely parallel the body's reticuloendothelial iron stores. The information provided is similar to that obtained from bone-marrow aspirates or biopsies stained for iron with Prussian Blue. Comparative studies indicate good correlation between iron content in the marrow and serum ferritin, except possibly in patients with leukemia and metastatic tumors to the bone marrow. The clinical value of the assay in relation to other indicators of iron status (i.e., hemoglobin, erythrocyte indices, serum iron and iron-binding capacity, and erythrocyte protoporphyrin) is in its specificity and sensitivity for assaying physiological iron stores.

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Immunoradiometric serum ferritin concentration compared with stainable bone-marrow iron as indices to iron stores.

Clinical Chemistry ◽

10.1093/clinchem/26.1.0145 ◽

1980 ◽

Vol 26 (1) ◽

pp. 145-147

Author(s):

D T Forman ◽

M V Vye

Keyword(s):

Bone Marrow ◽

Serum Ferritin ◽

Binding Capacity ◽

Iron Status ◽

Clinical Value ◽

Ferritin Concentration ◽

Iron Stores ◽

Specificity And Sensitivity ◽

Bone Marrow Iron ◽

Iron Binding Capacity

Abstract Immunoradiometric analysis has made it possible to measure ferritin reliably in serum. The determination is a sensitive means of assessing body iron because concentrations of ferritin closely parallel the body's reticuloendothelial iron stores. The information provided is similar to that obtained from bone-marrow aspirates or biopsies stained for iron with Prussian Blue. Comparative studies indicate good correlation between iron content in the marrow and serum ferritin, except possibly in patients with leukemia and metastatic tumors to the bone marrow. The clinical value of the assay in relation to other indicators of iron status (i.e., hemoglobin, erythrocyte indices, serum iron and iron-binding capacity, and erythrocyte protoporphyrin) is in its specificity and sensitivity for assaying physiological iron stores.

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Serum Ferritin Level Remains a Reliable Marker of Bone Marrow Iron Stores Evaluated by Histomorphometry in Hemodialysis Patients

Clinical Journal of the American Society of Nephrology ◽

10.2215/cjn.01630408 ◽

2008 ◽

Vol 4 (1) ◽

pp. 105-109 ◽

Cited By ~ 28

Author(s):

Lillian A. Rocha ◽

Daniela V. Barreto ◽

Fellype C. Barreto ◽

Cristiane B. Dias ◽

Rosa Moysés ◽

...

Keyword(s):

Bone Marrow ◽

Serum Ferritin ◽

Serum Ferritin Level ◽

Ferritin Level ◽

Hemodialysis Patients ◽

Iron Stores ◽

Bone Marrow Iron ◽

Reliable Marker

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Bone Marrow Cellularity and Iron Stores in Chronic Renal Failure

Acta Haematologica ◽

10.1159/000207281 ◽

1980 ◽

Vol 64 (5) ◽

pp. 265-270 ◽

Cited By ~ 4

Author(s):

Danel O. Ho-Yen ◽

Najma Saleem ◽

Laura W. Fleming ◽

William K. Stewart ◽

Henry B. Goodall

Keyword(s):

Bone Marrow ◽

Renal Failure ◽

Chronic Renal Failure ◽

Iron Stores ◽

Bone Marrow Cellularity ◽

Marrow Cellularity

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Correlation between serum ferritin and bone marrow iron stores

Tropical Doctor ◽

10.1177/0049475516678478 ◽

2016 ◽

Vol 47 (3) ◽

pp. 217-221 ◽

Cited By ~ 1

Author(s):

Anupama K V ◽

Purnima S Rao ◽

Sushma Adappa ◽

Prashantha Balanthimogru ◽

Chakrapani Mahabala

Keyword(s):

Bone Marrow ◽

Correlation Coefficient ◽

Serum Ferritin ◽

Characteristic Curve ◽

Iron Store ◽

Cross Sectional ◽

Cutoff Value ◽

Iron Stores ◽

Bone Marrow Iron ◽

Spearman’S Correlation

Bone marrow aspirate examination is a gold standard to assess bone marrow iron stores. The correlation between serum ferritin and bone marrow iron has not been established in detail, as the cutoff value for iron stores have not been uniformly established. Ours was a cross-sectional study. Perl’s Prussian blue stain was used to stain bone marrow, assessed by Gale’s grading. Receiver operating characteristic curve analysis and Spearman’s correlation coefficient calculated. Gale’s grading revealed iron store deficiency in 26 and sufficiency in 13. Spearman’s correlation coefficient of 0.90 showed a significant relation between serum ferritin and bone marrow iron stores. A serum ferritin of 228 pmol/L had high sensitivity and specificity for iron deficiency; our study suggests that this level be taken as the cutoff value to predict iron store deficiency in bone marrow.

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