Relationship between Sodium Clearance and Proximal Tubular Fluid Output in Conscious Unoperated Rats Adapted to Different Dietary Sodium Contents

Abstract The case of a 13-year-old boy with the advanced clinical picture of the idiopa thic DeToni-Debré-Fanconi syndrome is described, on whom acute studies of proximal tubular functions and of the effect of furosemide thereon were performed. Sodium bicarbonate loading corrected the hyperchloremic acidosis, but induced an increase of urinary bicarbonate loss of over 20 % of the filtered amount. Furosemide corrected bicarbonate reabsorption in spite of the presence of metabolic alkalosis. The urinary excretion of alpha-amino nitrogen, glucose, and phosphates decreased and tubular reabsorption of the two latter increased under furosemide. On a chronic treatment with furosemide and dietary sodium chloride restriction, correction of hyperchloremic acidosis, hypophosphatemia and rickets was achieved.

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Sodium-Lithium Countertransport is Not a Marker of Proximal Tubular Sodium Clearance

Journal of Cardiovascular Pharmacology ◽

10.1097/00005344-199006167-00016 ◽

1990 ◽

Vol 16 ◽

pp. S50-S51 ◽

Cited By ~ 2

Author(s):

Timothy J. B. Maling ◽

Robert W. L. Siebers

Keyword(s):

Proximal Tubular ◽

Sodium Clearance

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Renal haemodynamics, sodium and water reabsorption during continuous intravenous infusion of recombinant interleukin-2

Clinical Science ◽

10.1042/cs0950073 ◽

1998 ◽

Vol 95 (1) ◽

pp. 73-81 ◽

Cited By ~ 5

Author(s):

Poul F. GEERTSEN ◽

Hans VON DER MAASE ◽

Niels Vidiendal OLSEN ◽

Niels FOGH-ANDERSEN ◽

Steen Levin NIELSEN ◽

...

Keyword(s):

Blood Flow ◽

Cardiac Output ◽

Glomerular Filtration Rate ◽

Filtration Rate ◽

Interleukin 2 ◽

Continuous Intravenous Infusion ◽

Recombinant Interleukin 2 ◽

Proximal Tubular ◽

Reabsorption Rate ◽

Sodium Clearance

1.Renal haemodynamics, lithium and sodium clearance were measured in 14 patients treated with recombinant interleukin-2 for metastatic renal cell carcinoma. 2.Patients were studied before and after 72 h of continuous intravenous infusion of recombinant interleukin-2 (18×106 i.u.·24 h-1·m-2) and 48 h post therapy. Cardiac output was measured by impedance cardiography. Effective renal plasma flow and glomerular filtration rate were determined by the renal clearances of 131I-hippuran and 99mTc-diethylenetriaminepenta-acetic acid (DTPA) respectively. Renal clearance of lithium (CLi) was used as an index of proximal tubular outflow. 3.Treatment caused a transient decrease in mean arterial blood pressure and systemic vascular resistance, but cardiac output remained unchanged. Renal blood flow decreased and renal vascular resistance increased during and after treatment. Sodium clearance decreased from 1.10 (0.63/1.19) ml/min to 0.17 (0.18/0.32) ml/min (P = 0.003). Glomerular filtration rate remained unchanged, whereas the median CLi decreased from 26 (17/32) ml/min to 17 (10/21) ml/min (P = 0.008). Calculated absolute proximal reabsorption rate of water increased from 63 (40/69) ml/min to 71 (47/82) ml/min (P = 0.04). The urinary excretion rate of thromboxane B2 and the ratio between excretion rates of thromboxane B2 and 6-keto-prostaglandin-F1α increased by 98% (P = 0.022) and 175% (P = 0.022) respectively. 4.The study suggests a specific recombinant interleukin-2-induced renal vasoconstrictor effect. Changes in renal prostaglandin synthesis may contribute to the decrease in renal blood flow. The lithium clearance data suggest that an increased proximal tubular reabsorption rate may contribute to the decreased sodium clearance during recombinant interleukin-2 treatment.

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