Prevalence of MEFV gene mutations and their clinical correlations in Turkish children with Henoch-Schönlein purpura

2011 ◽  
Vol 100 (5) ◽  
pp. 745-749 ◽  
Author(s):  
Cengiz Bayram ◽  
Gülay Demircin ◽  
Özlem Erdoğan ◽  
Mehmet Bülbül ◽  
Aysun Çaltık ◽  
...  
Keyword(s):  
Mefv Gene ◽  
Gene Mutations ◽  
Henoch Schonlein Purpura ◽  
Turkish Children ◽  
Clinical Correlations ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

MEFV gene mutations in children with Henoch–Schönlein purpura and their correlations—do mutations matter?

2019 ◽  
Vol 38 (7) ◽  
pp. 1947-1952 ◽  
Author(s):  
Evrim Kargin Cakici ◽  
Eda Didem Kurt Şükür ◽  
Sare Gülfem Özlü ◽  
Fatma Yazılıtaş ◽  
Semanur Özdel ◽  
...  
Keyword(s):  
Mefv Gene ◽  
Gene Mutations ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Prevalence and significance of the MEFV gene mutations in childhood Henoch–Schönlein purpura without FMF symptoms

2012 ◽  
Vol 33 (2) ◽  
pp. 377-380 ◽  
Author(s):  
Cagla Serpil Dogan ◽  
Sema Akman ◽  
Mustafa Koyun ◽  
Turker Bilgen ◽  
Elif Comak ◽  
...  
Keyword(s):  
Mefv Gene ◽  
Gene Mutations ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

scholarly journals MEFV gene mutations in Egyptian children with Henoch-Schonlein purpura

2014 ◽  
Vol 12 (1) ◽  
pp. 41 ◽  
Author(s):  
Samia Salah ◽  
Samia Rizk ◽  
Hala M Lotfy ◽  
Salma EL Houchi ◽  
Huda Marzouk ◽  
...  
Keyword(s):  
Mefv Gene ◽  
Gene Mutations ◽  
Henoch Schonlein Purpura ◽  
Egyptian Children ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

MEFV Mutations Modify the Clinical Presentation of Henoch-Schönlein Purpura

2008 ◽  
Vol 35 (12) ◽  
pp. 2427-2429 ◽  
Author(s):  
Z. BÝRSÝN ÖZÇAKAR ◽  
FATOS YALÇINKAYA ◽  
NÝLGÜN ÇAKAR ◽  
BANU ACAR ◽  
ÖZGÜR KASAPÇOPUR ◽  
...  
Keyword(s):  
Mutation Analysis ◽  
Clinical Presentation ◽  
Gene Mutations ◽  
Henoch Schonlein Purpura ◽  
Reactive Protein ◽  
Mefv Mutations ◽  
Mediterranean Fever ◽  
Turkish Patients ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

ObjectiveTo investigate the prevalence of MEFV gene mutations in Turkish patients with Henoch-Schönlein purpura (HSP) but with no symptoms of familial Mediterranean fever (FMF). In addition, we assessed the clinical and laboratory characteristics of HSP patients with and without MEFV mutations.MethodsEighty pediatric patients with HSP (44 boys and 36 girls) were enrolled. Blood for mutation analysis was obtained either at the time of the diagnosis of HSP or during followup visits in previously diagnosed patients. No patient had the diagnosis of FMF in their history and in the followup period. Exon 10 of the MEFV gene was screened, together with p.E148Q mutation analysis.ResultsTwenty-seven (34%) patients were found to be heterozygous for one of the screened MEFV mutations; p.M694V in 16, p.M680I in 5, p.V726A in 3, and p.E148Q in 3 patients. Patients with MEFV mutations were younger than those without mutations and they had edema and arthritis more frequently. Also, the frequencies of elevated erythrocyte sedimentation rate and C-reactive protein values were found to be significantly higher in patients who had MEFV mutations.ConclusionAlterations in the MEFV gene are important susceptibility factors for the development of HSP and also affect the clinical presentation of it.

Sign in / Sign up

Export Citation Format

Share Document