RENAL LESIONS IN RATS WITH LONG-TERM ALLOXAN DIABETES

The clinical course of nephrosis in five infants with onset of disease before 7 months of age is presented, together with evaluation of renal lesions seen at necropsy. The problems of the management of nephrosis susceptibility to infection and water and electrolyte imbalance were found to be exaggerated by the young age of the patients. The renal pathology observed in these five infants consisted of persistence of immature glomeruli and dilatation of the tubules in the cortical area. Later, the immature glomeruli and associated tubules appear to atrophy and the remaining glomeruli to hypertrophy. Long-term adrenocorticosteroid therapy seems to be contraindicated, not only on the basis of the pathologic changes, but because it greatly exaggerates the problems of management and does not effect a remission of the disease.

Download Full-text

A case of chronic myelogenous leukemia with hemolytic uremic syndrome similar renal lesions during long- term interferon - .ALPHA. therapy.

Nihon Naika Gakkai Zasshi ◽

10.2169/naika.86.1259 ◽

1997 ◽

Vol 86 (7) ◽

pp. 1259-1261 ◽

Cited By ~ 5

Author(s):

HIDEYUKI KOBAYASHI

Keyword(s):

Hemolytic Uremic Syndrome ◽

Chronic Myelogenous Leukemia ◽

Interferon Alpha ◽

Myelogenous Leukemia ◽

Renal Lesions ◽

Interferon Alpha Therapy ◽

Uremic Syndrome ◽

Alpha Therapy

Download Full-text

GLOMERULAR BASEMENT MEMBRANE THICKENING IN RATS WITH LONG-TERM ALLOXAN DIABETES

Acta Pathologica Microbiologica Scandinavica Section A Pathology ◽

10.1111/j.1699-0463.1974.tb03845.x ◽

2009 ◽

Vol 82A (2) ◽

pp. 211-219

Author(s):

Erik Hägg

Keyword(s):

Basement Membrane ◽

Glomerular Basement Membrane ◽

Alloxan Diabetes ◽

Basement Membrane Thickening ◽

Glomerular Basement Membrane Thickening

Download Full-text

THE MECHANISM OF THE PROTECTIVE ACTION OF CLAMPING THE RENAL PEDICLES OF DOGS WITH ALLOXAN DIABETES

Journal of Endocrinology ◽

10.1677/joe.0.0080245 ◽

1952 ◽

Vol 8 (3) ◽

pp. 245-249 ◽

Cited By ~ 2

Author(s):

J. L. ARTETA

Keyword(s):

Alloxan Diabetes ◽

Protective Action ◽

Toxic Effects ◽

Sympathetic Chain ◽

Renal Lesions ◽

Reflex Change ◽

Splanchnic Nerves ◽

Renal Vessels

Clamping of the renal vessels gives rise to a reflex change of circulation at the level of the vascular zone innervated by the splanchnic nerves. Bilateral cutting of the splanchnic nerves and of the inferior part of the sympathetic chain at the level of the thorax prevents the reflex, and annuls the protective action of clamping the vascular pedicles of the kidney. Renal lesions are not absolutely necessary for the production of alloxan diabetes, but may aggravate diabetes, probably by adding the toxic effects of retention of urine.

Download Full-text