Evaluation of Down's syndrome screening population data sets by simulation: analyser-specific parameters may be superior to meta-analysis-derived parameters

2007 ◽  
Vol 62 (5) ◽  
pp. 735-743 ◽  
Author(s):  
T. M. Reynolds ◽  
G. Vranken ◽  
J. Van Nueten ◽  
J. Aldis
Keyword(s):  
Meta Analysis ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Population Data ◽  
Data Sets ◽  
Screening Population

scholarly journals Two kinds of common prenatal screening tests for Down’s syndrome: a systematic review and meta-analysis

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yuan Yao ◽  
Yang Liao ◽  
Mei Han ◽  
Sheng-Lan Li ◽  
Juan Luo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Prenatal Screening ◽  
Meta Analysis ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Screening Tests

scholarly journals Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis

2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Tereza Cristina Pinheiro Diogenes ◽  
Felipe Alves Mourato ◽  
José Luiz de Lima Filho ◽  
Sandra da Silva Mattos
Keyword(s):  
Gender Differences ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Meta Analysis ◽  
Down's Syndrome ◽  
Down’S Syndrome

scholarly journals Altered pro-inflammatory and anti-inflammatory plasma cytokines levels in children with Down's syndrome: A meta-analysis

2021 ◽  
Vol 10 (10) ◽  
pp. 3568
Author(s):  
Nitu Nigam ◽  
PrithviK Singh ◽  
Neena Raizada ◽  
BalendraP Singh ◽  
Shalini Tripathi ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Plasma Cytokines ◽  
Anti Inflammatory

scholarly journals APOE ε4 influences the manifestation of Alzheimer's disease in adults with Down's syndrome

2000 ◽  
Vol 176 (5) ◽  
pp. 468-472 ◽  
Author(s):  
Shoumitro Deb ◽  
John Braganza ◽  
Nadine Norton ◽  
Hywel Williams ◽  
Patrick G. Kehoe ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Meta Analysis ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Learning Disabled ◽  
Current Data ◽  
Additional Group ◽  
Ε4 Allele ◽  
Specific Manifestation

BackgroundRecent studies of the relationship between the apolipoprotein E (APOE) gene and Alzheimer's disease in adults with Down's syndrome have revealed inconsistent results.AimsTo assess the role of the APOE gene in the manifestation of Alzheimer's disease in adults with Down's syndrome.MethodWe studied the APOE genotypes of 24 adults with dementia and 33 non-demented adults with Down's syndrome over 35 years of age, and an additional group of 164 non-learning disabled adults. We also carried out a meta-analysis of all previously published studies of association between APOE and Down's syndrome, incorporating the current data.ResultsWe observed a non-significant excess of APOE ε4 and a reduction of ε2 in adults with dementia compared with non-demented adults with Down's syndrome in our sample. However, meta-analysis showed a significantly higher frequency of ε4 in adults with dementia compared with non-demented adults with Down's syndrome (odds ratio=2.02, 95% CI 1.33–3.07, P=0.001), but no significant reduction in the frequency of ε2.ConclusionsThe APOE ε4 allele acts as a risk factor for the age-specific manifestation of Alzheimer's disease in people with Down's syndrome.

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