scholarly journals Inhibition of mouse acrosome reaction and sperm-zona pellucida binding by anti-human sperm membrane protein 1 antibody

2007 ◽  
Vol 9 (1) ◽  
pp. 23-29 ◽  
Author(s):  
Guo-Yan Cheng ◽  
Jian-Li Shi ◽  
Min Wang ◽  
Yan-Qin Hu ◽  
Chun-Meng Liu ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Zona Pellucida ◽  
Acrosome Reaction ◽  
Human Sperm ◽  
Sperm Membrane

scholarly journals TMEM95 is a sperm membrane protein essential for mammalian fertilization

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Ismael Lamas-Toranzo ◽  
Julieta G Hamze ◽  
Enrica Bianchi ◽  
Beatriz Fernández-Fuertes ◽  
Serafín Pérez-Cerezales ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Membrane Fusion ◽  
Zona Pellucida ◽  
Sperm Protein ◽  
Egg Protein ◽  
Egg Membrane ◽  
Sperm Membrane ◽  
Mammalian Fertilization ◽  
Male Specific ◽  
Mechanical Injection

The fusion of gamete membranes during fertilization is an essential process for sexual reproduction. Despite its importance, only three proteins are known to be indispensable for sperm-egg membrane fusion: the sperm proteins IZUMO1 and SPACA6, and the egg protein JUNO. Here we demonstrate that another sperm protein, TMEM95, is necessary for sperm-egg interaction. TMEM95 ablation in mice caused complete male-specific infertility. Sperm lacking this protein were morphologically normal exhibited normal motility, and could penetrate the zona pellucida and bind to the oolemma. However, once bound to the oolemma, TMEM95-deficient sperm were unable to fuse with the egg membrane or penetrate into the ooplasm, and fertilization could only be achieved by mechanical injection of one sperm into the ooplasm, thereby bypassing membrane fusion. These data demonstrate that TMEM95 is essential for mammalian fertilization.

scholarly journals Antiidiotypic antibody related to the 84 kD human sperm membrane protein

Cell Research ◽  
1990 ◽  
Vol 1 (2) ◽  
pp. 163-172
Author(s):  
Jun Yu ◽  
Linfang Wang ◽  
Shiying Miao ◽  
Yuanchang Yan
Keyword(s):  
Membrane Protein ◽  
Human Sperm ◽  
Antiidiotypic Antibody ◽  
Sperm Membrane
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