scholarly journals The effect of composition and ageing on the dissolution rates of chlorpropamide-urea solid dispersions

1977 ◽  
Vol 29 (1) ◽  
pp. 688-694 ◽  
Author(s):  
JAMES L. FORD ◽  
MICHAEL H. RUBINSTEIN
Keyword(s):  
Solid Dispersions ◽  
Dissolution Rates

scholarly journals The Role of Functional Excipients in Solid Oral Dosage Forms to Overcome Poor Drug Dissolution and Bioavailability

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 393 ◽  
Author(s):  
Jannes van der Merwe ◽  
Jan Steenekamp ◽  
Dewald Steyn ◽  
Josias Hamman
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersions ◽  
Aqueous Solubility ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Drug Dissolution ◽  
Specific Reference ◽  
Dissolution Rates ◽  
Bioavailability Enhancement ◽  
Poor Solubility

Many active pharmaceutical ingredients (APIs) exhibit poor solubility and low dissolution rates in aqueous environments such as the luminal fluids of the gastrointestinal tract. The oral bioavailability of these compounds is usually very low as a result of their poor solubility properties. In order to improve the bioavailability of these poorly soluble drugs, formulation strategies have been applied as a means to improve their aqueous solubility and dissolution rates. With respect to formulation approaches, excipients can be incorporated in the formulation to assist in the dissolution process of the drug, or specialized dosage forms can be formulated that improve dissolution rate through various mechanisms. This paper provides an overview of selected excipients (e.g., alkalinizing agents, surfactants and sugars) that can be used in formulations to increase the dissolution rate as well as specialized dosage forms such as self-emulsifying delivery systems and formulation techniques such as inclusion complexes and solid dispersions. These formulation approaches are discussed with available examples with specific reference to positive outcomes in terms of drug solubility and bioavailability enhancement.

scholarly journals Increased dissolution rates of tranilast solid dispersions extruded with inorganic excipients

2017 ◽  
Vol 43 (6) ◽  
pp. 947-957 ◽  
Author(s):  
Mohammed Maniruzzaman ◽  
Steven A. Ross ◽  
Muhammad Tariqul Islam ◽  
Nikolaos Scoutaris ◽  
Arun Nair ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Dissolution Rates

scholarly journals KARAKTERISASI FISIKOKIMIA DAN LAJU DISOLUSI DISPERSI PADAT IBUPROFEN DENGAN PEMBAWA POLIETILENGLIKOL 6000

2015 ◽  
Vol 4 (1) ◽  
pp. 25
Author(s):  
Erizal Zaini ◽  
Rahmi x Rahmi Nofita ◽  
Salman ◽  
Irna Kurniati
Keyword(s):  
Polyethylene Glycol ◽  
Solid Dispersion ◽  
Solid Dispersions ◽  
Polarized Light ◽  
Water Soluble ◽  
Dissolution Rates ◽  
Hot Stage Microscopy ◽  
Enhanced Dissolution ◽  
Water Soluble Compound ◽  
Polyethylene Glycol 6000

 Solid dispersions of the antiinflamation drug ibuprofen and polyethylene glycol 6000 (PEG 6000) were prepared by the melting method in order to increase the dissolution rates of this poorly water-soluble compound. The temperature/composition phase diagram of binary system was analyzed by termal analysis hot-stage microscopy, showing an eutectic formation. Polarized light hot stage microscopy and X-ray-powder diffraction confirmed, that solid dispersion technique decrease the crystalliny of ibuprofen after melting and solidifying of a 4/6 (w/w) mixture of ibuprofen and polyethylene glycol 6000 respectively, which the results enhanced dissolution rates compared to the physical mixtures and ibuprofen intact. However, no such chemical interactions in the solid state were confirmed by FTIR spectra which showed the presence of ibuprofen crystalline in solid dispersion.   

Chemometric Modelling of Dissolution Rates of Griseofulvin From Solid Dispersions With Polymers

1989 ◽  
Vol 15 (9) ◽  
pp. 1375-1391 ◽  
Author(s):  
Daniela Bonelli ◽  
Sergio Clementi ◽  
Cynthia Ebert ◽  
Mara Lovrecich ◽  
Fulvio Rubessa
Keyword(s):  
Solid Dispersions ◽  
Dissolution Rates

Dissolution rates of different drugs from solid dispersions with Eudragit RS

1995 ◽  
Vol 3 (5) ◽  
pp. 265-271 ◽  
Author(s):  
Piero De Filippis ◽  
Guglielmo Zingone ◽  
Mario Gibellini ◽  
Fulvio Rubessa ◽  
Paolo Rupena
Keyword(s):  
Solid Dispersions ◽  
Dissolution Rates ◽  
Eudragit Rs

Stability and Dissolution Rates of Corticosteroids in Polyethylene Glycol Solid Dispersions

1984 ◽  
Vol 10 (5) ◽  
pp. 771-787 ◽  
Author(s):  
Saleh A. H. Khalil ◽  
Sawsan Abd El-Fattah ◽  
Lobna M. Mortada
Keyword(s):  
Polyethylene Glycol ◽  
Solid Dispersions ◽  
Dissolution Rates

Solubility Enhancement of Poorly Soluble Drug Simvastatin by Solid Dispersion Technique

2016 ◽  
Vol 2 (2) ◽  
pp. 91-95
Author(s):  
Neelima Rani T ◽  
Pavani A ◽  
Sobhita Rani P ◽  
Srilakshmi N
Keyword(s):  
Dissolution Rate ◽  
Drug Carrier ◽  
Solid Dispersions ◽  
Aqueous Solubility ◽  
Onset Of Action ◽  
Kneading Method ◽  
Wetting Property ◽  
Poorly Soluble ◽  
Dispersion Technique ◽  
Low Solubility

This study aims to formulate solid dispersions (SDs) of Simvastatin (SIM) to improve the aqueous solubility, dissolution rate and to facilitate faster onset of action. Simvastatin is a BCS class II drug having low solubility & therefore low oral bioavailability. In the present study, SDs of simvastatin different drug-carrier ratios were prepared by kneading method. The results showed that simvastatin solubility & dissolution rate enhanced with polymer SSG in the ratio 1:7 due to increase in wetting property or possibly may be due to change in crystallinity of the drug.

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