Permanent left bundle branch pacing: What is the mechanism of divergent responses during programmed stimulation?

2020 ◽  
Vol 31 (5) ◽  
pp. 1222-1225 ◽  
Author(s):  
Marek Jastrzębski
Keyword(s):  
Programmed Stimulation

scholarly journals Quantitation of day to day variability in mode of induction of ventricular tachyarrhythmias by programmed stimulation

1988 ◽  
Vol 11 (1) ◽  
pp. 101-108 ◽  
Author(s):  
Mark J Cooper ◽  
Lesley J Hunt ◽  
Kathy J Palmer ◽  
A.Robert Denniss ◽  
David A Richards ◽  
...  
Keyword(s):  
Ventricular Tachyarrhythmias ◽  
Programmed Stimulation

Abstract 12008: Nos1 Adapter Protein Nos1ap Overexpression Alters Qtc Intervals in Transgenic Mice

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Tatjana Williams ◽  
Anahi P Arias-Loza ◽  
Marco Abeßer ◽  
Joachim Schmitt ◽  
Kai Schuh ◽  
...  
Keyword(s):  
Ion Channels ◽  
Sudden Cardiac Death ◽  
Transgenic Mice ◽  
Cardiac Death ◽  
Genetic Alterations ◽  
Luciferase Assay ◽  
Qtc Interval ◽  
Cross Sectional ◽  
Programmed Stimulation ◽  
Increased Susceptibility

Background: Congenital long- or short-QT syndrome may lead to life-threatening ventricular tachycardia and sudden cardiac death. Apart from rare disease-causing mutations in ion channels, common genetic variations in the neuronal nitric oxide synthase (NOS1) regulator NOS1AP, have recently been associated with QT interval variations in a human whole-genome association study. In fact, NOS1AP SNPs have been linked to increases in QTc intervals and sudden cardiac death. We therefore speculate that myocardial NOS1AP overexpression may lead to a decrease of the QTc interval and an increased susceptibility to rhythm disorders. Methods and Results: We generated transgenic mice (TG) with a conditional myocardial NOS1AP overexpression and focused on electrical alterations. Conditional overexpression of NOS1AP resulted in a 147% ventricular increase in TG mice compared to WT littermates. NOS1AP was mainly located at the sarcolemma where it interacted with NOS1 and the L-type Ca2+- channel. HW/BW ratio, ventricular ANP expression, ventricular cross-sectional area and collagen deposition were not altered in NOS1AP mice under baseline conditions. However, NOS1AP overexpressing mice showed a clear decrease of QTc intervals (33 vs. 48 ms). They were more prone to bradycardia (resting heart rate 467 bpm vs. 666 bpm). Atrial programmed stimulation repeatedly caused atrial tachycardia. Ventricular programmed stimulation caused VT in some mice with NOS1AP overexpression. We also investigated the functional effect of the human rs16847548 (T/C). We found that this SNP decreased NOS1AP promoter activity in a viral NOS1AP luciferase assay, suggesting that this SNP downregulates NOS1AP expression in humans. Conclusion: Myocardial overexpression of NOS1AP leads to a significant shortening of the QTc interval with an increased susceptibility to atrial and ventricular rhythm disorders. SNP rs16847548 in NOS1AP resulted in downregulation of NOS1AP expression which provides an explanation for elongation of QTc intervals. In summary, not only a mutation in ion channels itself but also genetic alterations in expression of ion channel modifiers, such as NOS1AP, have an impact on QTc intervals.

Value of the signal-averaged electrocardiogram as a predictor of the results of programmed stimulation in nonsustained ventricular tachycardia

1988 ◽  
Vol 61 (15) ◽  
pp. 1272-1278 ◽  
Author(s):  
Gioia Turitto ◽  
John M. Fontaine ◽  
Shantha N. Ursell ◽  
Edward B. Caref ◽  
Raphael Henkin ◽  
...  
Keyword(s):  
Ventricular Tachycardia ◽  
Nonsustained Ventricular Tachycardia ◽  
Programmed Stimulation

Programmed stimulation in patients with minor forms of right ventricular dysplasia

1989 ◽  
Vol 10 (suppl D) ◽  
pp. 49-53 ◽  
Author(s):  
M. Di Biase ◽  
S. Favale ◽  
V. Massari ◽  
G. Amodio ◽  
A. Chiddo ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Programmed Stimulation ◽  
Right Ventricular Dysplasia

Role of bandpass filters in optimizing the value of the signal-averaged electrocardiogram as a predictor of the results of programmed stimulation

1989 ◽  
Vol 64 (1) ◽  
pp. 16-26 ◽  
Author(s):  
Edward B. Caref ◽  
Gioia Turitto ◽  
Bassiema B. Ibrahim ◽  
Raphael Henkin ◽  
Nabil El-Sherif
Keyword(s):  
Bandpass Filters ◽  
Programmed Stimulation

Analysis of programmed stimulation methods in the evaluation of ventricular arrhythmias in patients 20 years old and younger

1990 ◽  
Vol 66 (10) ◽  
pp. 826-830 ◽  
Author(s):  
Michael J. Silka ◽  
Jack Kron ◽  
Joel E. Cutler ◽  
John H. McAnulty
Keyword(s):  
Ventricular Arrhythmias ◽  
Programmed Stimulation

scholarly journals Epicardial mapping of the onset of ventricular tachycardia initiated by programmed stimulation in the canine heart with chronic infarction.

Circulation ◽  
1979 ◽  
Vol 60 (6) ◽  
pp. 1375-1384 ◽  
Author(s):  
G J Klein ◽  
R E Ideker ◽  
W M Smith ◽  
L A Harrison ◽  
J Kasell ◽  
...  
Keyword(s):  
Ventricular Tachycardia ◽  
Canine Heart ◽  
Epicardial Mapping ◽  
Programmed Stimulation

Twenty Years of Programmed Stimulation of the Heart: Where to go From Here?

1988 ◽  
Vol 11 (1) ◽  
pp. 120-121
Author(s):  
S. SERGE BAROLD
Keyword(s):  
Programmed Stimulation ◽  
Stimulation Of
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