This chapter aims to identify, analyze, and classify the methodologies and methods described in the literature for the usability evaluation of systems and services based on information and communication technologies. The methodology used was a systematic review of the literature. The studies included in the analysis were classified into empirical and analytical methodologies (test, inquiry, controlled experiment, or inspection). A total of 2116 studies were included, of which 1308 were classified. In terms of results, the inquiry methodology was the most frequent in this review, followed by test, inspection, and finally, the controlled experiment methodology. A combination of methodologies is relatively common, especially the combination of test and inquiry methodologies, probably because they assess different but complementary aspects of usability contributing to a more comprehensive assessment.