Controlled trial of ligation plus vasoconstrictor versus proton pump inhibitor in the control of acute esophageal variceal bleeding

2013 ◽  
Vol 28 (4) ◽  
pp. 684-689 ◽  
Author(s):  
Gin-Ho Lo ◽  
Daw-Shyong Perng ◽  
Chi-Yang Chang ◽  
Chi-Ming Tai ◽  
Huay-Min Wang ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Variceal Bleeding ◽  
Controlled Trial ◽  
Esophageal Variceal ◽  
Esophageal Variceal Bleeding

A clinical controlled trial of endoscopic sclerotherapy for repeated esophageal variceal bleeding

1989 ◽  
Vol 24 (1) ◽  
pp. 70-74 ◽  
Author(s):  
Kuo-Liang Wu ◽  
Pai-Dai Chou ◽  
Chao-Ming Huang ◽  
Hung-Shuen Tang ◽  
Chiuan-Fu Chen ◽  
...  
Keyword(s):  
Variceal Bleeding ◽  
Controlled Trial ◽  
Endoscopic Sclerotherapy ◽  
Esophageal Variceal ◽  
Esophageal Variceal Bleeding

scholarly journals A Randomized Controlled Study of Fuzheng Huayu Capsule for Prevention of Esophageal Variceal Bleeding in Patients with Liver Cirrhosis

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Jie Gu ◽  
Qin Zhang ◽  
Dongying Xue ◽  
Hong Cai ◽  
Lieming Xu
Keyword(s):  
Variceal Bleeding ◽  
Controlled Trial ◽  
Survival Rates ◽  
Controlled Study ◽  
Esophageal Variceal ◽  
Esophageal Variceal Bleeding ◽  
Randomized Controlled ◽  
Cirrhotic Patients ◽  
Upper Gastrointestinal

To elucidate the role of Fuzheng Huayu Capsule, a herbal formula, in the prevention of esophageal variceal bleeding in cirrhotic patients, a multicenter randomized and placebo-controlled trial was carried out. One hundred forty-six cirrhotic patients with esophageal varices were enrolled to compare the probability of upper gastrointestinal bleeding and survival between Fuzheng Huayu Capsule group and controlled group for the duration of 2 years. The results demonstrated that the FZHYC could effectively reduce the risk of variceal bleeding and improve survival rates for cirrhotic patients with varices, especially the combination of the capsule and Propranolol, which presented a better effect; FZHYC could reduce the varices size in patients with small ones. Its effect may be related to the amelioration of hepatic fibrosis.

scholarly journals Effects of Proton Pump Inhibitor on Gastroesophageal Varices of Cirrhosis: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Xiaoning Chen ◽  
Tao Zhou ◽  
Ting Zhou ◽  
Yueyue Li ◽  
Xin Sun ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Adverse Events ◽  
Proton Pump ◽  
Variceal Bleeding ◽  
Endoscopic Therapy ◽  
Controlled Trial ◽  
Primary Prophylaxis ◽  
Secondary Prophylaxis ◽  
Gastroesophageal Varices ◽  
Acute Bleeding

Abstract BackgroundThe use of proton pump inhibitor (PPI) for gastroesophageal varices in patients with cirrhosis after endoscopic therapy remains controversial. This study aimed to evaluate the effect of PPI on gastroesophageal varices in patients with cirrhosis after endoscopic therapy, including variceal bleeding and adverse events.MethodsBetween May 2017 and June 2019, cirrhotic patients with gastroesophageal varices confirmed by endoscopy were considered for enrollment in this study. Eligible subjects were randomized into two groups: one group received PPI for 14 days and the other group did not undergo PPI treatment. Patients were followed up for 8 weeks.ResultsDuring the follow-up period, three patients (3/53, 5.66%) in the PPI group experienced variceal bleeding on day 9, 16, and 25 after endoscopic therapy, including one patient with primary prophylaxis and two with acute bleeding. In the non-PPI group, three patients (3/56, 5.66%) suffered from variceal bleeding on day 7, 42, and 56 after endoscopic therapy, including two patients with secondary prophylaxis and one with acute bleeding (P>0.99). The rate of adverse events was similar between the two groups (38% vs. 28%, P=0.30). Furthermore, the average hospitalization expense of patients in the PPI group was higher than that of patients in the non-PPI group ($2305 vs. $3096, P<0.001).ConclusionsPPI does not appear to reduce variceal bleeding and adverse events in patients with cirrhosis after endoscopic therapy.Trial registration: This trial was registered with ClinicalTrials.gov (NCT 03175731, 05/06/2017).

A randomized controlled trial comparing octreotide and vasopressin in the control of acute esophageal variceal bleeding

1992 ◽  
Vol 16 (3) ◽  
pp. 320-325 ◽  
Author(s):  
Shinn-Jang Hwang ◽  
Han-Chieh Lin ◽  
Chia-Fu Chang ◽  
Fa-Yauh Lee ◽  
Chi-Wen Lu ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Variceal Bleeding ◽  
Controlled Trial ◽  
Esophageal Variceal ◽  
Esophageal Variceal Bleeding ◽  
Randomized Controlled
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