A Randomized Controlled Study of Fuzheng Huayu Capsule for Prevention of Esophageal Variceal Bleeding in Patients with Liver Cirrhosis

To elucidate the role of Fuzheng Huayu Capsule, a herbal formula, in the prevention of esophageal variceal bleeding in cirrhotic patients, a multicenter randomized and placebo-controlled trial was carried out. One hundred forty-six cirrhotic patients with esophageal varices were enrolled to compare the probability of upper gastrointestinal bleeding and survival between Fuzheng Huayu Capsule group and controlled group for the duration of 2 years. The results demonstrated that the FZHYC could effectively reduce the risk of variceal bleeding and improve survival rates for cirrhotic patients with varices, especially the combination of the capsule and Propranolol, which presented a better effect; FZHYC could reduce the varices size in patients with small ones. Its effect may be related to the amelioration of hepatic fibrosis.

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The results of a randomized controlled trial evaluating TIPS and endoscopic therapy in cirrhotic patients with gastro-esophageal variceal bleeding

European Journal of Gastroenterology & Hepatology ◽

10.1097/00042737-199912000-00226 ◽

1999 ◽

Vol 11 (12) ◽

pp. A86

Author(s):

H. R. van Buuren ◽

M. Groeneweg ◽

F. P. Vleggaar ◽

W. Lesterhuis ◽

A. J.P. van Tilburg ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Variceal Bleeding ◽

Endoscopic Therapy ◽

Controlled Trial ◽

Esophageal Variceal ◽

Esophageal Variceal Bleeding ◽

Randomized Controlled ◽

Cirrhotic Patients

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Randomized Controlled Trial of Long-Term Proton Pump Inhibitor (PPI) in the Prevention of Esophageal Variceal Bleeding in Cirrhotic Patients

The American Journal of Gastroenterology ◽

10.14309/00000434-200509001-00747 ◽

2005 ◽

Vol 100 ◽

pp. S278

Author(s):

Hajime Kuwayama ◽

Ryoichi Nishiki

Keyword(s):

Randomized Controlled Trial ◽

Proton Pump Inhibitor ◽

Proton Pump ◽

Variceal Bleeding ◽

Controlled Trial ◽

Esophageal Variceal ◽

Esophageal Variceal Bleeding ◽

Randomized Controlled ◽

Cirrhotic Patients

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Propranolol alone may not be acceptable to prevent first esophageal variceal bleeding in Japanese cirrhotic patients: Randomized controlled trial

Journal of Gastroenterology and Hepatology ◽

10.1111/j.1440-1746.2003.03331.x ◽

2004 ◽

Vol 19 (5) ◽

pp. 576-581 ◽

Cited By ~ 3

Author(s):

MORIMASA TOMIKAWA ◽

RINSHUN SHIMABUKURO ◽

KEISHI OKITA ◽

NORIFUMI TSUTSUMI ◽

TOMOHIKO AKAHOSHI ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Variceal Bleeding ◽

Controlled Trial ◽

Esophageal Variceal ◽

Esophageal Variceal Bleeding ◽

Randomized Controlled ◽

Cirrhotic Patients

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Early TIPS versus endoscopic therapy for secondary prophylaxis after management of acute esophageal variceal bleeding in cirrhotic patients: a meta-analysis of randomized controlled trials

Journal of Gastroenterology and Hepatology ◽

10.1111/jgh.13303 ◽

2016 ◽

Vol 31 (9) ◽

pp. 1519-1526 ◽

Cited By ~ 22

Author(s):

Shadi Al Halabi ◽

Tarek Sawas ◽

Besher Sadat ◽

Aiyah Jandali ◽

Hadi Al Halabi ◽

...

Keyword(s):

Variceal Bleeding ◽

Endoscopic Therapy ◽

Meta Analysis ◽

Secondary Prophylaxis ◽

Controlled Trials ◽

Esophageal Variceal ◽

Esophageal Variceal Bleeding ◽

Randomized Controlled ◽

Cirrhotic Patients ◽

Early Tips

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226 Comparison of terlipressin and octreotide as a combination therapy with endoscopic variceal ligation in the control of acute esophageal variceal bleeding: A randomized, controlled study

Journal of Hepatology ◽

10.1016/s0168-8278(06)80227-8 ◽

2006 ◽

Vol 44 ◽

pp. S91 ◽

Cited By ~ 1

Author(s):

S.B. Cho ◽

W.S. Lee ◽

C.H. Park ◽

Y.E. Joo ◽

H.S. Kim ◽

...

Keyword(s):

Combination Therapy ◽

Variceal Bleeding ◽

Randomized Controlled Study ◽

Controlled Study ◽

Endoscopic Variceal Ligation ◽

Esophageal Variceal ◽

Esophageal Variceal Bleeding ◽

Randomized Controlled

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IMPACT OF ESOPHAGEAL VARICEAL LIGATION COMBINED PROPRANOLOL ON PORTAL HYPERTENSIVE GASTROPATHY IN CIRRHOTIC PATIENTS

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2013.5.10 ◽

2013 ◽

pp. 64-70

Author(s):

Pham Chi Tran

Keyword(s):

Variceal Bleeding ◽

Controlled Study ◽

Control Group ◽

Study Group ◽

Portal Hypertensive Gastropathy ◽

Esophageal Variceal ◽

Esophageal Variceal Bleeding ◽

Cirrhotic Patients ◽

Esophageal Variceal Ligation ◽

The Impact

Objectives: 1. To investigate the prevalence of portal hypertensive gastropathy (PHG) and the ratio of mild/severe PHG. 2. The impact of esophageal variceal ligation (EVL) combined propranolol on the progress of PHG in terms of prevalence, distribution and severity. Patients and methods: Prospective, controlled study. Cirrhotic patients with the history of esophageal variceal bleeding or acute esophageal variceal bleeding in stable condition were devided into combined group: EVL combined propranolol (study group) and propranolol only (control group). Results: Sex ratio Male/Female: 82/4 = 20.5. Majority of cirrhotic etiology was alcohol: 73.3%. Esophageal varices grade II and III, no grade I. Prevalence of PHG: 90.7%, ratio of mild/ severe PHG: 12.8%/87.2%. The ratio, distribution and severity of PHG between the study group and control group after 3 and 6 months were not significantly different. Conclusions: 1. The prevalence of PHG: 90.7%, the ratio of mild/severe PHG: 12.8%/87.2%. 2. EVL combined propranolol did not change significantly the prevalence, distribution and severity ofPHG in comparison with propranolol group. Key words: Cirrhosis, portal hypertensive gastropathy, esophageal variceal ligation, propranolol.

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