Association of daily sleep duration with the incident dementia by serum soluble TREM2 in a community

2021 ◽  
Author(s):  
Tomoyuki Ohara ◽  
Jun Hata ◽  
Masashi Tanaka ◽  
Takanori Honda ◽  
Hajime Yamakage ◽  
...  
Keyword(s):  
Sleep Duration ◽  
Incident Dementia ◽  
Soluble Trem2

Letter re: Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia

Neurology ◽  
2017 ◽  
Vol 89 (14) ◽  
pp. 1532.2-1532
Author(s):  
Claudio Liguori ◽  
Francesca Izzi ◽  
Nicola B. Mercuri ◽  
Fabio Placidi
Keyword(s):  
Sleep Duration ◽  
Incident Dementia

scholarly journals Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia

Neurology ◽  
2017 ◽  
Vol 88 (12) ◽  
pp. 1172-1179 ◽  
Author(s):  
Andrew J. Westwood ◽  
Alexa Beiser ◽  
Nikita Jain ◽  
Jayandra J. Himali ◽  
Charles DeCarli ◽  
...  
Keyword(s):  
Sleep Duration ◽  
Brain Aging ◽  
Clinical Tool ◽  
High School Degree ◽  
Incident Dementia ◽  
Heart Study ◽  
Increased Risk ◽  
Trail Making ◽  
Multivariable Analyses

Objective:To evaluate the association between sleep duration and the risk of incident dementia and brain aging.Methods:Self-reported total hours of sleep were examined in the Framingham Heart Study (n = 2,457, mean age 72 ± 6 years, 57% women) as a 3-level variable: <6 hours (short), 6–9 hours (reference), and >9 hours (long), and was related to the risk of incident dementia over 10 years, and cross-sectionally to total cerebral brain volume (TCBV) and cognitive performance.Results:We observed 234 cases of all-cause dementia over 10 years of follow-up. In multivariable analyses, prolonged sleep duration was associated with an increased risk of incident dementia (hazard ratio [HR] 2.01; 95% confidence interval [CI] 1.24–3.26). These findings were driven by persons with baseline mild cognitive impairment (HR 2.83; 95% CI 1.06–7.55) and persons without a high school degree (HR 6.05; 95% CI 3.00–12.18). Transitioning to sleeping >9 hours over a mean period of 13 years before baseline was associated with an increased risk of all-cause dementia (HR 2.43; 95% CI 1.44–4.11) and clinical Alzheimer disease (HR 2.20; 95% CI 1.17–4.13). Relative to sleeping 6–9 hours, long sleep duration was also associated cross-sectionally with smaller TCBV (β ± SE, −1.08 ± 0.41 mean units of TCBV difference) and poorer executive function (β ± SE, −0.41 ± 0.13 SD units of Trail Making Test B minus A score difference).Conclusions:Prolonged sleep duration may be a marker of early neurodegeneration and hence a useful clinical tool to identify those at a higher risk of progressing to clinical dementia within 10 years.

Author response: Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia

Neurology ◽  
2017 ◽  
Vol 89 (14) ◽  
pp. 1533.2-1533
Author(s):  
Matthew P. Pase ◽  
Andrew J. Westwood ◽  
Alexa Beiser ◽  
Nikita Jain ◽  
Charles DeCarli ◽  
...  
Keyword(s):  
Sleep Duration ◽  
Author Response ◽  
Incident Dementia

scholarly journals Does Inflammation Mediate the Association Between Sleep Duration and Incident Dementia Among Older Adults?

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 119-119
Author(s):  
Chenkai Wu ◽  
Weihao Xu
Keyword(s):  
Older Adults ◽  
Sleep Duration ◽  
Inflammation Markers ◽  
Cox Models ◽  
Reactive Protein ◽  
Body Composition Study ◽  
Incident Dementia ◽  
Long Sleep ◽  
Health Aging ◽  
Factor Α

Abstract Sleep duration is a risk factor for multiple health outcomes. Growing attention has been directed to the association between sleep duration and dementia; however, results were inconsistent and the mechanisms remained largely unknown. We hypothesized that elevated levels of inflammation markers— C reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)—would mediate the association between sleep duration and dementia among older adults. Data were from the Health, Aging, and Body Composition Study; 3,010 participants free of dementia at baseline were included. Sleep duration was classified into: short (&lt;6 hours), normal (6-8 hours), and long (&gt;8 hours). Incident dementia was defined as (i) use of prescribed dementia medications, (ii) adjudicated dementia diagnosis, or (iii) a race-stratified cognitive decline &gt;1.5 SDs from the baseline mean. We used Cox models to examine the associations among sleep duration, inflammation, and dementia. The average age was 73.6 years (SD=2.9); 49% were male and 41% were black. During 10 years of follow-up, 515 participants (17.1%) developed dementia. Long sleep duration was associated with higher hazard of dementia than normal sleep duration (HR=1.50, 95%CI=1.02-2.21). This association was attenuated by approximately 10% when CRP or IL-6 was added in the model. When all three inflammation markers were included in the model, the hazard ratio of long sleep duration was reduced by nearly 30% and no longer significant (HR=1.36, 95%CI=0.89-2.08). Long sleep duration was associated with high risk of incident dementia among older adults and the association was partly explained by elevated levels of inflammation markers.

Author response: Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia

Neurology ◽  
2017 ◽  
Vol 89 (14) ◽  
pp. 1532.3-1533
Author(s):  
Matthew P. Pase ◽  
Sudha Seshadri
Keyword(s):  
Sleep Duration ◽  
Author Response ◽  
Incident Dementia

Letter re: Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia

Neurology ◽  
2017 ◽  
Vol 89 (14) ◽  
pp. 1533.1-1533
Author(s):  
Sunil Munakomi
Keyword(s):  
Sleep Duration ◽  
Incident Dementia

scholarly journals Changes in sleep duration and the risk of incident dementia in the elderly Japanese: the Ohsaki Cohort 2006 Study

SLEEP ◽  
2018 ◽  
Vol 41 (10) ◽  
Author(s):  
Yukai Lu ◽  
Yumi Sugawara ◽  
Shu Zhang ◽  
Yasutake Tomata ◽  
Ichiro Tsuji
Keyword(s):  
Sleep Duration ◽  
The Elderly ◽  
Incident Dementia ◽  
Elderly Japanese

Restrict Insomniacs' Sleep Duration, Set Rules for Time in Bed

2012 ◽  
Vol 45 (3) ◽  
pp. 33
Author(s):  
M. ALEXANDER OTTO
Keyword(s):  
Sleep Duration ◽  
Time In Bed

Predicting Incident Dementia in Parkinson's Disease

2013 ◽  
Author(s):  
Alexander I. Troster ◽  
Steven P. Woods
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Incident Dementia
Sign in / Sign up

Export Citation Format

Share Document