GD3 synthase deletion alters retinal structure and impairs visual function in mice

2021 ◽  
Author(s):  
Carla Andreia Abreu ◽  
Leandro Coelho Teixeira‐Pinheiro ◽  
Rafael Lani‐Louzada ◽  
Almir Jordão da Silva‐Junior ◽  
Juliana F. Vasques ◽  
...  
Keyword(s):  
Visual Function ◽  
Gd3 Synthase ◽  
Retinal Structure

scholarly journals Assessment of visual function and retinal structure following acute light exposure in the light sensitive T4R rhodopsin mutant dog

2016 ◽  
Vol 146 ◽  
pp. 341-353 ◽  
Author(s):  
Simone Iwabe ◽  
Gui-Shuang Ying ◽  
Gustavo D. Aguirre ◽  
William A. Beltran
Keyword(s):  
Visual Function ◽  
Light Exposure ◽  
Retinal Structure

scholarly journals Visual Function and Central Retinal Structure in Choroideremia

2016 ◽  
Vol 57 (9) ◽  
pp. OCT377 ◽  
Author(s):  
Elise Heon ◽  
Talal Alabduljalil ◽  
David B. McGuigan ◽  
Artur V. Cideciyan ◽  
Shuning Li ◽  
...  
Keyword(s):  
Visual Function ◽  
Retinal Structure

scholarly journals Correlation of Retinal Structure and Visual Function Assessments in Mouse Diabetes Models

2021 ◽  
Vol 62 (10) ◽  
pp. 20
Author(s):  
Sarah R. Sheskey ◽  
David A. Antonetti ◽  
René C. Rentería ◽  
Cheng-Mao Lin
Keyword(s):  
Visual Function ◽  
Retinal Structure

CRB1-associated retinal dystrophies in a Belgian cohort: genetic characteristics and long-term clinical follow-up

2021 ◽  
pp. bjophthalmol-2020-316781
Author(s):  
Mays Talib ◽  
Caroline Van Cauwenbergh ◽  
Julie De Zaeytijd ◽  
David Van Wynsberghe ◽  
Elfride De Baere ◽  
...  
Keyword(s):  
Visual Function ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Posterior Uveitis ◽  
Cone Dystrophy ◽  
Macular Dystrophy ◽  
Genetic Characteristics ◽  
Retinal Dystrophies ◽  
Retinal Structure

AimTo investigate the natural history in a Belgian cohort of CRB1-associated retinal dystrophies.MethodsAn in-depth retrospective study focusing on visual function and retinal structure.ResultsForty patients from 35 families were included (ages: 2.5–80.1 years). In patients with a follow-up of >1 year (63%), the mean follow-up time was 12.0 years (range: 2.3–29.2 years). Based on the patient history, symptoms and/or electroretinography, 22 patients (55%) were diagnosed with retinitis pigmentosa (RP), 15 (38%) with Leber congenital amaurosis (LCA) and 3 (8%) with macular dystrophy (MD), the latter being associated with the p.(Ile167_Gly169del) mutation (in compound heterozygosity). MD later developed into a rod-cone dystrophy in one patient. Blindness at initial presentation was seen in the first decade of life in LCA, and in the fifth decade of life in RP. Eventually, 28 patients (70%) reached visual acuity-based blindness (<0.05). Visual field-based blindness (<10°) was documented in 17/25 patients (68%). Five patients (13%) developed Coats-like exudative vasculopathy. Intermediate/posterior uveitis was found in three patients (8%). Cystoid maculopathy was common in RP (9/21; 43%) and MD (3/3; 100%). Macular involvement, varying from retinal pigment epithelium alterations to complete outer retinal atrophy, was observed in all patients.ConclusionBi-allelic CRB1 mutations result in a range of progressive retinal disorders, most of which are generalised, with characteristically early macular involvement. Visual function and retinal structure analysis indicates a window for potential intervention with gene therapy before the fourth decade of life in RP and the first decade in LCA.

Evaluation of Visual Function and Retinal Structure in Adult Amblyopes

2015 ◽  
Vol 92 (3) ◽  
pp. 375-383 ◽  
Author(s):  
Consuelo Pérez-Rico ◽  
Esperanza García-Romo ◽  
Juan Gros-Otero ◽  
Isabel Roldán-Díaz ◽  
Juan Arévalo-Serrano ◽  
...  
Keyword(s):  
Visual Function ◽  
Retinal Structure

scholarly journals The association between visual function and retinal structure in chronic central serous chorioretinopathy

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Aya Sugiura ◽  
Ryosuke Fujino ◽  
Nobuko Takemiya ◽  
Kimiko Shimizu ◽  
Masato Matsuura ◽  
...  
Keyword(s):  
Visual Function ◽  
Central Serous Chorioretinopathy ◽  
Chronic Central Serous Chorioretinopathy ◽  
Retinal Structure

Inner retinal structure and visual function after idiopathic epiretinal membrane surgery with and without brilliant blue G

2021 ◽  
Author(s):  
Asuka Takeyama ◽  
Yutaka Imamura ◽  
Masaki Shibata ◽  
Yuko Komiya ◽  
Masahiro Ishida
Keyword(s):  
Visual Function ◽  
Epiretinal Membrane ◽  
Brilliant Blue ◽  
Brilliant Blue G ◽  
Idiopathic Epiretinal Membrane ◽  
Retinal Structure
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