Rapid changes in brain aromatase activity in the female quail brain following expression of sexual behaviour

2017 ◽  
Vol 29 (11) ◽  
pp. e12542 ◽  
Author(s):  
C. de Bournonville ◽  
G. F. Ball ◽  
J. Balthazart ◽  
C. A. Cornil
Keyword(s):  
Sexual Behaviour ◽  
Aromatase Activity ◽  
Female Quail ◽  
Brain Aromatase ◽  
Rapid Changes

scholarly journals Rapid Control of Brain Aromatase Activity by Glutamatergic Inputs

Endocrinology ◽  
2006 ◽  
Vol 147 (1) ◽  
pp. 359-366 ◽  
Author(s):  
Jacques Balthazart ◽  
Michelle Baillien ◽  
Gregory F. Ball
Keyword(s):  
Brain Function ◽  
Time Course ◽  
Aminobutyric Acid ◽  
Aromatase Activity ◽  
Brain Aromatase ◽  
Rapid Control ◽  
Rapid Changes ◽  
Glutamate Agonists ◽  
Membrane Effects ◽  
The Brain

Estrogens derived from the neural aromatization of testosterone play a key role in the activation of male sexual behavior in many vertebrates and have now been recognized to have rapid membrane effects on brain function. Such changes in aromatase activity and hence in local estrogen concentrations could rapidly modulate behavioral responses. We show here that there is a very rapid (within minutes) decrease in aromatase activity in quail hypothalamic explants exposed to treatments affecting intracellular Ca2+ concentrations, such as the addition of glutamate agonists (kainate, α-amino-3-hydroxymethyl-4-isoxazole propionic acid, and, to a much lesser extent, N-methyl-d-aspartate), but not of γ-aminobutyric acid. The kainate effects, which reduce aromatase activity by 25–50%, are observed within 5 min, are completely blocked in explants exposed to specific kainate antagonists (6-cyano-7-nitroquinoxaline-2,3-dione disodium or 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium), and are also rapidly reversible when effectors are washed out. Together, these data support the idea that the synthesis of estrogen can be rapidly regulated in the brain, thus producing rapid changes in local estrogen bioavailability that could rapidly modify brain function with a time course similar to what has previously been described for neurotransmitters and neuromodulators.

Phosphorylation processes mediate rapid changes of brain aromatase activity

2001 ◽  
Vol 79 (1-5) ◽  
pp. 261-277 ◽  
Author(s):  
Jacques Balthazart ◽  
Michelle Baillien ◽  
Gregory F Ball
Keyword(s):  
Aromatase Activity ◽  
Brain Aromatase ◽  
Rapid Changes

scholarly journals Relationships between rapid changes in local aromatase activity and estradiol concentrations in male and female quail brain

2014 ◽  
Vol 65 (2) ◽  
pp. 154-164 ◽  
Author(s):  
M.J. Dickens ◽  
C. de Bournonville ◽  
J. Balthazart ◽  
C.A. Cornil
Keyword(s):  
Aromatase Activity ◽  
Male And Female ◽  
Female Quail ◽  
Rapid Changes

Cellular Mechanisms Controlling Rapid Changes in Brain Aromatase Activity

2012 ◽  
pp. 416-437 ◽  
Author(s):  
Thierry D. Charlier ◽  
Charlotte A. Cornil ◽  
Gregory F. Ball ◽  
Jacques Balthazart
Keyword(s):  
Aromatase Activity ◽  
Cellular Mechanisms ◽  
Brain Aromatase ◽  
Rapid Changes

Rapid and Reversible Inhibition of Brain Aromatase Activity

2001 ◽  
Vol 13 (1) ◽  
pp. 63-73 ◽  
Author(s):  
J. Balthazart ◽  
M. Baillien ◽  
G. F. Ball
Keyword(s):  
Aromatase Activity ◽  
Reversible Inhibition ◽  
Brain Aromatase

Brain aromatase activity and mRNA expression in a fish with male sexual polymorphism

2006 ◽  
Vol 27 (1) ◽  
pp. 142
Author(s):  
David Gonçalves ◽  
João Alpedrinha ◽  
Ana Domingues ◽  
Magda Teles ◽  
Rui F. Oliveira
Keyword(s):  
Mrna Expression ◽  
Aromatase Activity ◽  
Brain Aromatase

Neurochemical Control of Rapid Stress-Induced Changes in Brain Aromatase Activity

2013 ◽  
Vol 25 (4) ◽  
pp. 329-339 ◽  
Author(s):  
M. J. Dickens ◽  
C. A. Cornil ◽  
J. Balthazart
Keyword(s):  
Aromatase Activity ◽  
Brain Aromatase ◽  
Induced Changes

Effects of photoperiod on formation of oestradiol-17β in the dove brain

1986 ◽  
Vol 109 (3) ◽  
pp. 371-377 ◽  
Author(s):  
J. B. Hutchison ◽  
Th. Steimer ◽  
P. Jaggard
Keyword(s):  
Preoptic Area ◽  
Direct Action ◽  
Specific Effect ◽  
Short Photoperiod ◽  
Aromatase Activity ◽  
Vocal Behaviour ◽  
Brain Aromatase ◽  
Hormone Sensitive ◽  
Short Days

ABSTRACT The effects of photoperiod and castration on brain aromatase activity have been examined using an in-vitro radioassay. Formation of oestradiol-17β was lower in the preoptic area of male Barbary doves on a short daylength (6 h light: 18 h darkness) than in males on a long daylength (14 h light: 10 h darkness). This was a specific effect of photoperiod which did not influence aromatase activity in the anterior or posterior hypothalamic areas, and was not accompanied by changes in hormone-sensitive vocal behaviour. Production of 5β-dihydrotestosterone, 5β-androstane-3α,17β-diol and 5α-dihydrotestosterone by the preoptic area did not differ between birds on long or short days. Therefore, a short photoperiod does not appear to influence other pathways of androgen metabolism. In contrast to the effects of photoperiod, castration reduced oestradiol formation in both preoptic and hypothalamic areas. Intramuscular injection of testosterone propionate (TP) in intact males on short days did not restore the pattern of distribution of aromatase activity seen in males on long days. Preoptic aromatase activity was, however, restored by TP in castrated birds. We conclude that a short photoperiod influences both the activity of aromatase and the inductive effect of testosterone on enzyme activity in the preoptic area, which is known to be associated with the behavioural action of oestrogen in the dove. Photoperiod is likely to act both through changes in circulating androgen and by a direct action on preoptic cells. J. Endocr. (1986) 109, 371–377

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