Symptom Experience Associated With Immunosuppressive Medications in Chinese Kidney Transplant Recipients

Drug-induced hematological cytopenia is common in kidney transplantation. Various cytopenia including leucopenia (neutropenia), thrombocytopenia, and anemia can occur in kidney transplant recipients. Persistent severe leucopenia or neutropenia can lead to opportunistic infections of various etiologies. On the contrary, reducing or stopping immunosuppressive medications in these events can provoke a rejection. Transplant clinicians are often faced with the delicate dilemma of balancing cytopenia and rejection from adjustments of immunosuppressive regimen. Differentials of drug-induced cytopenia are wide. Identification of culprit medication and subsequent modification is also challenging. In this review, we will discuss individual drug implicated in causing cytopenia and correlate it with corresponding literature evidence.

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BK Virus in Kidney Transplant Recipients: The Influence of Immunosuppression

Journal of Transplantation ◽

10.1155/2011/750836 ◽

2011 ◽

Vol 2011 ◽

pp. 1-9 ◽

Cited By ~ 12

Author(s):

Katherine A. Barraclough ◽

Nicole M. Isbel ◽

Christine E. Staatz ◽

David W. Johnson

Keyword(s):

Kidney Transplant ◽

Virus Replication ◽

Recent Literature ◽

Graft Loss ◽

Bk Virus ◽

Transplant Recipients ◽

Kidney Transplant Recipients ◽

Immunosuppressive Medications ◽

Reduction Strategies ◽

Specific Contribution

The incidence of BK virus infection in kidney transplant recipients has increased over recent decades, coincident with the use of more potent immunosuppression. More importantly, posttransplant BK virus replication has emerged as an important cause of graft damage and subsequent graft loss. Immunosuppression has been accepted as a major risk for BK virus replication. However, the specific contribution of individual immunosuppressive medications to this risk has not been well established. The purpose of this paper is to provide an overview of the recent literature on the influence of the various immunosuppressant drugs and drug combinations on posttransplant BK virus replication. Evidence supporting the various immunosuppression reduction strategies utilised in the management of BK virus will also be briefly discussed.

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Pattern and associated factors of adherence to immunosuppressive medications in kidney transplant recipients at a referral center in Iran

Patient Preference and Adherence ◽

10.2147/ppa.s198967 ◽

2019 ◽

Vol Volume 13 ◽

pp. 729-738

Author(s):

Omid Moradi ◽

Iman Karimzadeh ◽

Dorna Davani-Davari ◽

Mojtaba Shafiekhani ◽

Mohammad Mahdi Sagheb

Keyword(s):

Kidney Transplant ◽

Associated Factors ◽

Transplant Recipients ◽

Kidney Transplant Recipients ◽

Referral Center ◽

Immunosuppressive Medications

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Favorable Outcome of COVID-19 Pneumonia in a Kidney Transplant Recipient Treated with Tocilizumab

Case Reports in Infectious Diseases ◽

10.1155/2020/8830626 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

Adnane Guella ◽

Osman Elfadil ◽

Ghisson Abdulrazaq ◽

Sahla Osman ◽

Mohammed Munir Khan ◽

...

Keyword(s):

Kidney Transplant ◽

Transplant Patient ◽

Clinical Course ◽

Kidney Transplant Recipient ◽

Kidney Transplant Patient ◽

Transplant Recipients ◽

Kidney Transplant Recipients ◽

Immunosuppressive Medications ◽

Therapeutic Guidelines ◽

The Subject

The presentation of COVID-19 pneumonia in kidney transplant recipients is similar to that of the general population. However, in the former, it may have a worse clinical course. We report a kidney transplant patient affected by COVID-19 pneumonia whose condition worsened 9 days after the initial presentation. As no therapeutic guidelines on the subject are currently available, here we share our approach in the management of the immunosuppressive medications and the antiviral therapy and compare them to the scarce available data. We also expose the use of tocilizumab in our patient with excellent results.

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