Differences in proteomic profiles between yak and three cattle strains provide insights into molecular mechanisms underlying high‐altitude adaptation

2021 ◽  
Author(s):  
Jin‐Wei Xin ◽  
Zhi‐Xin Chai ◽  
Cheng‐Fu Zhang ◽  
Qiang Zhang ◽  
Yong Zhu ◽  
...  
Keyword(s):  
High Altitude ◽  
Molecular Mechanisms ◽  
High Altitude Adaptation ◽  
Altitude Adaptation

scholarly journals Pan-genome analyses of peach and its wild relatives provide insights into the genetics of disease resistance and species adaptation

2020 ◽  
Author(s):  
Ke Cao ◽  
Zhen Peng ◽  
Xing Zhao ◽  
Yong Li ◽  
Kuozhan Liu ◽  
...  
Keyword(s):  
High Altitude ◽  
Molecular Mechanisms ◽  
De Novo ◽  
Genomic Analysis ◽  
Gene Families ◽  
Wild Relatives ◽  
Comparative Genomic ◽  
High Altitude Adaptation ◽  
Pan Genome ◽  
Altitude Adaptation

AbstractAs a foundation to understand the molecular mechanisms of peach evolution and high-altitude adaptation, we performed de novo genome assembling of four wild relatives of P. persica, P. mira, P. kansuensis, P. davidiana and P. ferganensis. Through comparative genomic analysis, abundant genetic variations were identified in four wild species when compared to P. persica. Among them, a deletion, located at the promoter of Prupe.2G053600 in P. kansuensis, was validated to regulate the resistance to nematode. Next, a pan-genome was constructed which comprised 15,216 core gene families among four wild peaches and P. perisca. We identified the expanded and contracted gene families in different species and investigated their roles during peach evolution. Our results indicated that P. mira was the primitive ancestor of cultivated peach, and peach evolution was non-linear and a cross event might have occurred between P. mira and P. dulcis during the process. Combined with the selective sweeps identified using accessions of P. mira originating from different altitude regions, we proposed that nitrogen recovery was essential for high-altitude adaptation of P. mira through increasing its resistance to low temperature. The pan-genome constructed in our study provides a valuable resource for developing elite cultivars, studying the peach evolution, and characterizing the high-altitude adaptation in perennial crops.

scholarly journals Whole-genome sequence data suggests environmental adaptation of Ethiopian sheep populations

2021 ◽  
Author(s):  
Pamela Wiener ◽  
Christelle Robert ◽  
Abulgasim Ahbara ◽  
Mazdak Salavati ◽  
Ayele Abebe ◽  
...  
Keyword(s):  
High Altitude ◽  
Environmental Variables ◽  
Large Scale ◽  
Sequence Data ◽  
Strong Association ◽  
Environmental Adaptation ◽  
Whole Genome Sequence ◽  
Single Nucleotide Variants ◽  
High Altitude Adaptation ◽  
Altitude Adaptation

Abstract Great progress has been made over recent years in the identification of selection signatures in the genomes of livestock species. This work has primarily been carried out in commercial breeds for which the dominant selection pressures, are associated with artificial selection. As agriculture and food security are likely to be strongly affected by climate change, a better understanding of environment-imposed selection on agricultural species is warranted. Ethiopia is an ideal setting to investigate environmental adaptation in livestock due to its wide variation in geo-climatic characteristics and the extensive genetic and phenotypic variation of its livestock. Here, we identified over three million single nucleotide variants across 12 Ethiopian sheep populations and applied landscape genomics approaches to investigate the association between these variants and environmental variables. Our results suggest that environmental adaptation for precipitation-related variables is stronger than that related to altitude or temperature, consistent with large-scale meta-analyses of selection pressure across species. The set of genes showing association with environmental variables was enriched for genes highly expressed in human blood and nerve tissues. There was also evidence of enrichment for genes associated with high-altitude adaptation although no strong association was identified with hypoxia-inducible-factor (HIF) genes. One of the strongest altitude-related signals was for a collagen gene, consistent with previous studies of high-altitude adaptation. Several altitude-associated genes also showed evidence of adaptation with temperature, suggesting a relationship between responses to these environmental factors. These results provide a foundation to investigate further the effects of climatic variables on small ruminant populations.

Mitochondrial nt3010G-nt3970C haplotype is implicated in high-altitude adaptation of Tibetans

2011 ◽  
Vol 22 (5-6) ◽  
pp. 181-190 ◽  
Author(s):  
Yongjun Luo ◽  
Wenxiang Gao ◽  
Fuyu Liu ◽  
Yuqi Gao
Keyword(s):  
High Altitude ◽  
High Altitude Adaptation ◽  
Altitude Adaptation

High-Altitude Adaptation of Yak Based on Genetic Variants and Activity of Lactate Dehydrogenase-1

2010 ◽  
Vol 48 (5-6) ◽  
pp. 418-427 ◽  
Author(s):  
Liangde Kuang ◽  
Yucai Zheng ◽  
Yaqiu Lin ◽  
Yaou Xu ◽  
Suyu Jin ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
High Altitude ◽  
Genetic Variants ◽  
High Altitude Adaptation ◽  
Altitude Adaptation

scholarly journals Identification of a Tibetan-Specific Mutation in the Hypoxic Gene EGLN1 and Its Contribution to High-Altitude Adaptation

2013 ◽  
Vol 30 (8) ◽  
pp. 1889-1898 ◽  
Author(s):  
Kun Xiang ◽  
Ouzhuluobu ◽  
Yi Peng ◽  
Zhaohui Yang ◽  
Xiaoming Zhang ◽  
...  
Keyword(s):  
High Altitude ◽  
Specific Mutation ◽  
High Altitude Adaptation ◽  
Altitude Adaptation

scholarly journals Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation

2016 ◽  
Vol 48 (8) ◽  
pp. 947-952 ◽  
Author(s):  
Li Yu ◽  
Guo-Dong Wang ◽  
Jue Ruan ◽  
Yong-Bin Chen ◽  
Cui-Ping Yang ◽  
...  
Keyword(s):  
High Altitude ◽  
Genomic Analysis ◽  
High Altitude Adaptation ◽  
Altitude Adaptation

scholarly journals Angiotensin converting enzyme insertion allele in relation to high altitude adaptation

2001 ◽  
Vol 65 (6) ◽  
pp. 531-536 ◽  
Author(s):  
M. A. QADAR PASHA ◽  
A. P. KHAN ◽  
R. KUMAR ◽  
S. K. GROVER ◽  
R. B. RAM ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
High Altitude ◽  
Converting Enzyme ◽  
High Altitude Adaptation ◽  
Altitude Adaptation ◽  
Insertion Allele
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