Improvement of simplified inclined plane test for evaluation of thickened liquids by using optical sensor

Author(s):  
Toshitaka Yasuda
2018 ◽  
Vol 73 (11-12) ◽  
pp. 413-416 ◽  
Author(s):  
Abdur Rauf ◽  
Saud Bawazeer ◽  
Ghias Uddin ◽  
Bina S. Siddiqui ◽  
Haroon Khan ◽  
...  

Abstract The aim of the current work was to explore the muscle relaxant effect of pistagremic acid (PA) isolated from Pistacia integerrima in various animal paradigms. In a rotarod test, PA caused a significant (p<0.05) muscle relaxant potential in a dose-dependent manner. When studied in the inclined plane test, pretreatment with PA (5 and 10 mg/kg) caused promising activity (p<0.05) after treatment for 30, 60 and 90 min. The muscle relaxant potential of PA was strongly complimented by the traction and chimney tests, showing a dominant effect after 60 min of treatment. In conclusion, PA possesses strong muscle relaxant activity in various animal-based models.


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