scholarly journals A comparative time‐dependent study of hematology, serum gastrin concentrations, and gastroscopic assessment of meloxicam‐induced gastric ulceration in dogs

2021 ◽  
Vol 35 (5) ◽  
pp. 2196-2204
Author(s):  
Ahmed Elfadadny ◽  
Ahmed S. Mandour ◽  
Rokaia F. Ragab ◽  
Khalaf F. Alsharif ◽  
Gaber El‐Saber Batiha ◽  
...  
Keyword(s):  
Serum Gastrin ◽  
Gastric Ulceration ◽  
Time Dependent

Parenterally or enterally administered anti-somatostatin antibody induces increased gastrin in suckling rats

1994 ◽  
Vol 266 (3) ◽  
pp. G417-G424 ◽  
Author(s):  
M. G. Martin ◽  
S. V. Wu ◽  
G. Ohning ◽  
H. Wong ◽  
J. H. Walsh
Keyword(s):  
Monoclonal Antibody ◽  
Serum Gastrin ◽  
Cell Activity ◽  
Time Dependent ◽  
Gastrin Cell ◽  
Suckling Rats ◽  
Antibody Absorption ◽  
Serum Gastrin Concentration ◽  
Dependent Mechanism

This study demonstrates the effectiveness of parenteral and oral anti-somatostatin monoclonal antibody to stimulate gastrin cell activity in suckling rats. Intraperitoneal anti-somatostatin monoclonal antibody increased serum gastrin concentration (> 2-fold), and orally administered antibodies retained their neutralizing capabilities as demonstrated by a 30% induction of gastrin synthesis. Absorption of luminal monoclonal antibody was time dependent and saturable as demonstrated by measurement of serum murine immunoglobulin G and the subsequent effects on serum gastrin and antral gastrin mRNA concentrations. Enhanced gastrin synthesis after oral administration required whole antibody in that enterally delivered F(ab')2 fragments were not absorbed and did not increase serum gastrin concentrations. In addition, pretreatment with excess Fc fragments decreased monoclonal antibody absorption and eliminated the serum gastrin response to oral monoclonal antibody. These results demonstrate that orally administered murine anti-somatostatin monoclonal antibody was rapidly and efficiently absorbed via an Fc-dependent mechanism and retained immunoneutralizing activity against endogenous somatostatin, neutralizing its inhibition of gastrin cell activity. These results indicate that orally administered monoclonal antibodies could potentially be used to determine the role of other peptides and growth factors as potential physiological regulators during the suckling period of postnatal development.

Time-Dependent Changes of Serum Gastrin and Gastrin Receptors in the Rat Oxyntic Mucosa after Proximal Gastric Vagotomy

1997 ◽  
Vol 67 (2) ◽  
pp. 186-192
Author(s):  
Angel J. Reina ◽  
Manuel López-Cantarero ◽  
Andrés Gallardo ◽  
Orlando Fuentes ◽  
Diego Gaitán ◽  
...  
Keyword(s):  
Serum Gastrin ◽  
Time Dependent ◽  
Oxyntic Mucosa ◽  
Proximal Gastric Vagotomy

Eleveted serum gastrin level cannot maintain basal and stimulated gastric acid secretion in histamine deficient transgenic mice

2001 ◽  
Vol 120 (5) ◽  
pp. A180-A180
Author(s):  
B HUNYADY ◽  
A ZOLYOMI ◽  
J CZIMMER ◽  
G MOZSIK ◽  
E BUZAS ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Serum Gastrin ◽  
Gastrin Level ◽  
Serum Gastrin Level

Gastrin and cyclooxygenase-2 (COX-2) expression in Helicobacter pylori (Hp) infected gastric ulceration

2001 ◽  
Vol 120 (5) ◽  
pp. A727-A727
Author(s):  
S KONTUREK ◽  
P KONTUREK ◽  
W BIELANSKI ◽  
A DUDA ◽  
M ZUCHOWICZ ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Ulceration ◽  
Cyclooxygenase 2 ◽  
Cox 2

Gastric Ulceration Following Vagotomy

1950 ◽  
Vol 16 (2) ◽  
pp. 495-496 ◽  
Author(s):  
John Weber ◽  
Harold L. Goldblum ◽  
Lucien A. Gregg
Keyword(s):  
Gastric Ulceration

Stress-induced gastric ulceration and activation of hypothalamic-pituitary-adrenocortical system: New insight of their interrelation

2004 ◽  
Author(s):  
L. P. Filaretova ◽  
T. T. Podvigina ◽  
T. T. Bagaeva ◽  
P. Yu. Bobryshev
Keyword(s):  
Gastric Ulceration ◽  
Adrenocortical System
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