gastric ulceration
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Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1836
Author(s):  
Mohamed A. Lebda ◽  
Rabab E. Mostafa ◽  
Nabil M. Taha ◽  
Eman M. Abd El-Maksoud ◽  
Hossam G. Tohamy ◽  
...  

Gastric ulceration is a multifactorial disease defined as a defect in the gastric wall that extends through the muscularis mucosae into the deeper layers of the wall. The most common cause of gastric ulceration is alcohol consumption. In the current study, rats were gavaged by ethanol to investigate the protective (before ethanol) and curative (after ethanol) ability of Commiphora myrrh (myrrh) oil and extract against gastric ulcer oxidative alterations induced by ethanol. Myrrh significantly improved ulcer index, histomorphology, and periodic acid Schiff (PAS) impaired by ethanol. In addition, myrrh improved the antioxidant potential of gastric mucosa through enhancement of nuclear factor related to erythroid 2 (Nrf2), total glutathione (GSH), reduced GSH, and oxidized glutathione (GSSG), along with significant reduction in malondialdehyde (MDA) levels. Amelioration of gastric oxidative stress by myrrh enables gastric mucosa to counteract the ethanol’s inflammatory and apoptotic processes leading to improved gastric proliferation and healing. Interestingly, myrrh extract showed better protective and curative effects than myrrh oil against gastric ulceration.


Author(s):  
Nkiruka Millicent Amadi ◽  
Peter Uwadiegwu Achukwu ◽  
S. O. Onwukwe ◽  
Emmanuel Ifeanyi Obeagu ◽  
Nonyelum V. Anoh ◽  
...  

Stomach ulceration study was carried on 25 groups (5 rats each of the groups), groups (E, E1, E2, , E3 and EC, placed on 24 hours fasting before the single dose of intra peritoneal dose administration of 5ml/kg body weight of 99% ethanol and  after one hour, received daily extract of dilution doses of ((500, 1000, 1500) mg /kg) body weight and 100 mg /kg body weight cimentidine (standard drug) respectively for 7 days. Groups (EA1, EA2, , EA3 and EAC, ) were treated with the same extract doses and drug concentration for 7 days before the dose ethanol administration. Group Eand 0 served as a positive control and a negative control respectively. On day 9, target organs; stomach and intestines were harvested under anaesthetize weighed, gross macroscopically and histomorphological studied. Result of the study showed plant inhibition on ethanol induced gastric ulceration; the standard drug (cemetidine) and the mapped extract doses of ((500, 1000, 1500) mg /kg) body weight respectively showed normal organ architecture. Ulcer index study activities 70% indicating evidence of curative and preventive index range 35 to 43% showed some inhibition as seen on the gastric mucosa of the treated group. It was observed that the treatment and anti- ulceration effect of boiled aqueous leaf extract metabolites showed reduction on the histomorphological changes in the gastric mucosa and provided inhibition effectiveness of ethanol induced injury.


Author(s):  
P. Witt ◽  
L. Kroon ◽  
N. Ankringa ◽  
M. Delany ◽  
L. W. L. Bruggen ◽  
...  

2021 ◽  
Vol 48 (3) ◽  
pp. 38-40
Author(s):  
J. Ananiev ◽  
M. Hadzhi ◽  
K. Ivanova

Abstract Malignant tumors of the heart are rare. Even rarer, however, are metastases to the heart from cancers originating from the gastrointestinal tract. This case report involves a 63-year-old patient who presented into the clinic with a gastric ulcer and subsequent haemorrhage, and who died after sudden cardiac arrest. Autopsy revealed a metastatic involvement of the heart muscle from low-grade carcinoma of the stomach, as well as many other organ metastases.


Agriculture ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 927
Author(s):  
Piotr Cybulski ◽  
Aleksandra Woźniak ◽  
Joachim Urban ◽  
Tomasz Stadejek

Specific anatomy of the porcine stomach results in a high risk of ulceration in the pars oesophagea. A fully developed ulcer leads to intermittent gastrointestinal bleeding followed by clinical symptoms of chronic pain; thus, gastric ulceration in pigs causes significant production losses and serious welfare problems. Nowadays, gastric ulceration is common in domestic pigs throughout the world, but a great deal of attention has been directed at finishers. This paper was intended to provide new data on the prevalence of the disease in commercially reared highly prolific sows. The study was carried out on 329 culled sows from four commercial farms located in Northern Poland. The severity of gross pathological lesions of pars oesophagea was assigned to grade 0 (no lesions), 1 (parakeratosis), 2 (erosion), or 3 (gastric ulceration with or without stenosis) by a veterinary practitioner. Abattoir analysis revealed 66.6% of sows’ stomachs with some degree of alterations. Gastric ulceration was detected in 45.5% of examined organs. Parakeratosis and erosion were found in 1.2 and 15.8% of stomachs, respectively. The investigation did not find any oesphageal strictures. Our investigation of the problem in high health status hyper-prolific sows showed the lowest prevalence of gastric lesions (i.e., ulcerative and preulcerative alterations collectively) compared to earlier studies but the highest percentage of gastric ulcers. The results indicate that gastric ulcers may be a highly prevalent and underestimated welfare issue in sows in modern pig production, worth further studies focusing on particular risk factors related to feeding, genetics, management issues, and sows longevity.


2021 ◽  
Vol 35 (5) ◽  
pp. 2196-2204
Author(s):  
Ahmed Elfadadny ◽  
Ahmed S. Mandour ◽  
Rokaia F. Ragab ◽  
Khalaf F. Alsharif ◽  
Gaber El‐Saber Batiha ◽  
...  

2021 ◽  
Vol 22 (14) ◽  
pp. 7437
Author(s):  
Michal Zalecki ◽  
Adrianna Plywacz ◽  
Hanna Antushevich ◽  
Amelia Franke-Radowiecka

Cocaine- and amphetamine-regulated transcript (CART) is a peptide suggested to play a role in gastrointestinal tract tissue reaction to pathology. Gastric ulceration is a common disorder affecting huge number of people, and additionally, it contributes to the loss of pig livestock production. Importantly, ulceration as a focal disruption affecting deeper layers of the stomach wall differs from other gastrointestinal pathologies and should be studied individually. The pig’s gastrointestinal tract, due to its many similarities to the human counterpart, provides a valuable experimental model for studying digestive system pathologies. To date, the role of CART in gastric ulceration and the expression of the gene encoding CART in porcine gastrointestinal tube are completely unknown. Therefore, we aimed to verify the changes in the CART expression by Q-PCR (gene encoding CART in the tissue) and double immunofluorescence staining combined with confocal microscopy (CART immunofluorescence in enteric nervous system) in the porcine stomach tissues adjacent to gastric ulcerations. Surprisingly, we found that gastric ulcer caused a significant decrease in the expression of CART-encoding gene and huge reduction in the percentage of CART-immunofluorescent myenteric perikarya and neuronal fibers located within the circular muscle layer. Our results indicate a unique CART-dependent gastric response to ulcer disease.


2021 ◽  
Vol 19 (5) ◽  
pp. 34-39
Author(s):  
Sara Santos

Helicobacter pylori bacteria can infect the gastrointestinal tract, with the potential to cause causing gastritis, peptic ulcer disease and/or gastric cancer. There are various diagnostic tools for H. pylori, with invasive gastroscopic biopsy as the gold standard. Infection can be eradicated with a combination of omeprazole, amoxicillin and clarithromycin. This article presents a case study of a 56-year-old woman who was diagnosed with an H. pylori-associated gastric ulcer and successfully treated with triple eradication therapy. It also explores the pathophysiology of H. pylori, covering its mechanisms of mobility, pH regulation and adhesion, as well as its virulence, expression of cytotoxins and potential progression to cancer.


2021 ◽  
pp. 104527
Author(s):  
Hugo Dunlop ◽  
Joshua Timmer ◽  
Steven McOrist

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