Closing in on premature closure bias

2017 ◽  
Vol 51 (11) ◽  
pp. 1095-1096 ◽  
Author(s):  
Sarah Blissett ◽  
Matthew Sibbald
Keyword(s):  
Premature Closure

Automation of Two-Stage Factor VIII Assay

1978 ◽  
Vol 39 (02) ◽  
pp. 455-465 ◽  
Author(s):  
Yvonne Stirling ◽  
D J Howarth ◽  
Marguerite Vickers ◽  
W R S North ◽  
T W Meade
Keyword(s):  
Factor Viii ◽  
Optical Density ◽  
Electric Circuit ◽  
Clotting Time ◽  
Two Stage ◽  
Laboratory Error ◽  
Premature Closure ◽  
Factor Viii Concentrates ◽  
Experimental Findings ◽  
Automated Methods

SummaryTwo automated methods for two-stage factor VIII assays have been compared with one another, and evaluated in practice. The Depex method records the clotting time when an electric circuit is completed by the formation of a fibrin thread across a hook-type electrode; the Electra method is based on an optical density technique of clot detection. The two methods gave comparable results for measured levels of factor VIII when haemophilic or “normal” plasmas were assayed. Results from the two methods in practice also suggest that both are valid at low and “normal” factor VIII levels. The Electra method is also probably suitable for assays of concentrates; however, the Depex method appears to give falsely high values in these circumstances, and experimental findings suggest that the reason may be that increased viscosity due to the high fibrinogen levels in factor VIII concentrates causes premature closure of the circuit between the two ends of the Depex electrode. The main advantage of the Depex method is that, provided 3 or 4 machines are available, a given number of assays can be completed more quickly than on Electra. The main advantages of Electra are that it is probably subject to less laboratory error than Depex, and that it is suitable for assaying concentrates as well as haemophilic and “normal” plasmas.

scholarly journals 4. On some Congenital Deformities of the Human Skull

1866 ◽  
Vol 5 ◽  
pp. 444-449
Author(s):  
Wm. Turner
Keyword(s):  
Natural History ◽  
Natural History Museum ◽  
The Other ◽  
History Museum ◽  
Human Skull ◽  
Congenital Deformities ◽  
Premature Closure ◽  
University Of Edinburgh ◽  
The University ◽  
Living Person

1st, Scaphocephalus.—After making reference to his previous papers, more especially to that in which he had described several specimens of the scaphocephalic skull, in which he had discussed the influence exercised on the production of deformities of the cranium, by a premature closure or obliteration of the sutures, and to the recent memoirs of Professor von Düben of Stockholm,† and Dr John Thurnam, the author proceeded to relate two additional cases of scaphocephalus to those he had already recorded. He had met with one of these in the head of a living person, the other in a skull in the Natural History Museum of the University of Edinburgh.

Functional premature closure of the fetal foramen ovale: A case report

2021 ◽  
Author(s):  
Shuang Ju ◽  
Shan Dong ◽  
Li Song ◽  
Qingcui Zhuo ◽  
Xiaoyue Liu ◽  
...  
Keyword(s):  
Case Report ◽  
Foramen Ovale ◽  
Premature Closure

Premature Closure of the Mitral Valve

CHEST Journal ◽  
1978 ◽  
Vol 73 (1) ◽  
pp. 121-123 ◽  
Author(s):  
John A. Ambrose ◽  
Jose Meller ◽  
Louis E. Teichholz ◽  
Michael V. Herman
Keyword(s):  
Mitral Valve ◽  
Premature Closure

scholarly journals Premature Closure of the Mitral and Tricuspid Valves

Circulation ◽  
1972 ◽  
Vol 45 (3) ◽  
pp. 663-671 ◽  
Author(s):  
DONALD A. SPRING ◽  
JOHN D. FOLTS ◽  
WILLIAM P. YOUNG ◽  
GEORGE G. ROWE
Keyword(s):  
Premature Closure

Checklists to prevent diagnostic errors: a pilot randomized controlled trial

Diagnosis ◽  
2015 ◽  
Vol 2 (3) ◽  
pp. 163-169 ◽  
Author(s):  
John W. Ely ◽  
Mark A. Graber
Keyword(s):  
Primary Care ◽  
Usual Care ◽  
Error Rate ◽  
Primary Care Physicians ◽  
Diagnostic Errors ◽  
Diagnostic Error ◽  
Diagnostic Process ◽  
Emergency Physicians ◽  
Mean Error ◽  
Premature Closure

AbstractMany diagnostic errors are caused by premature closure of the diagnostic process. To help prevent premature closure, we developed checklists that prompt physicians to consider all reasonable diagnoses for symptoms that commonly present in primary care.We enrolled 14 primary care physicians and 100 patients in a randomized clinical trial. The study took place in an emergency department (5 physicians) and a same-day access clinic (9 physicians). The physicians were randomized to usual care vs. diagnostic checklist. After completing the history and physical exam, checklist physicians read aloud a differential diagnosis checklist for the chief complaint. The primary outcome was diagnostic error, which was defined as a discrepancy between the diagnosis documented at the acute visit and the diagnosis based on a 1-month follow-up phone call and record review.There were 17 diagnostic errors. The mean error rate among the seven checklist physicians was not significantly different from the rate among the seven usual-care physicians (11.2% vs. 17.8%; p=0.46). In a post-hoc subgroup analysis, emergency physicians in the checklist group had a lower mean error rate than emergency physicians in the usual-care group (19.1% vs. 45.0%; p=0.04). Checklist physicians considered more diagnoses than usual-care physicians during the patient encounters (6.5 diagnoses [SD 4.2] vs. 3.4 diagnoses [SD 2.0], p<0.001).Checklists did not improve the diagnostic error rate in this study. However further development and testing of checklists in larger studies may be warranted.

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