scholarly journals Conventional Dorsal Root Ganglion Stimulation in an Experimental Model of Painful Diabetic Peripheral Neuropathy: A Quantitative Immunocytochemical Analysis of Intracellular γ‐Aminobutyric Acid in Dorsal Root Ganglion Neurons

2021 ◽  
Author(s):  
Glenn Franken ◽  
Perla Douven ◽  
Jacques Debets ◽  
Elbert A.J. Joosten
Keyword(s):  
Peripheral Neuropathy ◽  
Dorsal Root Ganglion ◽  
Experimental Model ◽  
Diabetic Peripheral Neuropathy ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Aminobutyric Acid ◽  
Immunocytochemical Analysis ◽  
Painful Diabetic Peripheral Neuropathy ◽  
Ganglion Neurons

scholarly journals Effects of niflumic acid on γ-aminobutyric acid-induced currents in isolated dorsal root ganglion neurons of neuropathic pain rats

2017 ◽  
Vol 14 (2) ◽  
pp. 1373-1380 ◽  
Author(s):  
Li-Jie Wang ◽  
Yang Wang ◽  
Meng-Jie Chen ◽  
Zhen-Pu Tian ◽  
Bi-Han Lu ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Niflumic Acid ◽  
Dorsal Root Ganglion Neurons ◽  
Aminobutyric Acid ◽  
Induced Currents ◽  
Ganglion Neurons

scholarly journals Long-Term Diabetic Microenvironment Augments the Decay Rate of Capsaicin-Induced Currents in Mouse Dorsal Root Ganglion Neurons

Molecules ◽  
2019 ◽  
Vol 24 (4) ◽  
pp. 775
Author(s):  
Xingjuan Chen ◽  
Yaqian Duan ◽  
Ashley Riley ◽  
Megan Welch ◽  
Fletcher White ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Dorsal Root Ganglion ◽  
Patch Clamp ◽  
Dorsal Root ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Dorsal Root Ganglion Neurons ◽  
Transient Receptor Potential Vanilloid ◽  
Drg Neurons ◽  
Ganglion Neurons

Individuals with end-stage diabetic peripheral neuropathy present with decreased pain sensation. Transient receptor potential vanilloid type 1 (TRPV1) is implicated in pain signaling and resides on sensory dorsal root ganglion (DRG) neurons. We investigated the expression and functional activity of TRPV1 in DRG neurons of the Ins2+/Akita mouse at 9 months of diabetes using immunohistochemistry, live single cell calcium imaging, and whole-cell patch-clamp electrophysiology. 2′,7′-Dichlorodihydrofluorescein diacetate (DCFH-DA) fluorescence assay was used to determine the level of Reactive Oxygen Species (ROS) in DRGs. Although TRPV1 expressing neuron percentage was increased in Ins2+/Akita DRGs at 9 months of diabetes compared to control, capsaicin-induced Ca2+ influx was smaller in isolated Ins2+/Akita DRG neurons, indicating impaired TRPV1 function. Consistently, capsaicin-induced Ca2+ influx was decreased in control DRG neurons cultured in the presence of 25 mM glucose for seven days versus those cultured with 5.5 mM glucose. The high glucose environment increased cytoplasmic ROS accumulation in cultured DRG neurons. Patch-clamp recordings revealed that capsaicin-activated currents decayed faster in isolated Ins2+/Akita DRG neurons as compared to those in control neurons. We propose that in poorly controlled diabetes, the accelerated rate of capsaicin-sensitive TRPV1 current decay in DRG neurons decreases overall TRPV1 activity and contributes to peripheral neuropathy.

Retrospective Case Series on the Treatment of Painful Diabetic Peripheral Neuropathy With Dorsal Root Ganglion Stimulation

2018 ◽  
Vol 21 (8) ◽  
pp. 787-792 ◽  
Author(s):  
Sam Eldabe ◽  
Anthony Espinet ◽  
Anders Wahlstedt ◽  
Porhan Kang ◽  
Liong Liem ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Dorsal Root Ganglion ◽  
Diabetic Peripheral Neuropathy ◽  
Dorsal Root ◽  
Case Series ◽  
Retrospective Case ◽  
Retrospective Case Series ◽  
Painful Diabetic Peripheral Neuropathy

TNF-α-mediated JNK activation in the dorsal root ganglion neurons contributes to Bortezomib-induced peripheral neuropathy

2014 ◽  
Vol 38 ◽  
pp. 185-191 ◽  
Author(s):  
Jie Zhang ◽  
Yi-Min Su ◽  
Dai Li ◽  
Yu Cui ◽  
Zhen-Zhen Huang ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Tnf Α ◽  
Ganglion Neurons ◽  
Jnk Activation

scholarly journals Anisatin modulation of the γ-aminobutyric acid receptor-channel in rat dorsal root ganglion neurons

1999 ◽  
Vol 127 (7) ◽  
pp. 1567-1576 ◽  
Author(s):  
Tomoko Ikeda ◽  
Yoshihisa Ozoe ◽  
Emi Okuyama ◽  
Keiichi Nagata ◽  
Hiroshi Honda ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Aminobutyric Acid ◽  
Acid Receptor ◽  
Ganglion Neurons ◽  
Receptor Channel

scholarly journals Dorsal root ganglion neurons become hyperexcitable and increase expression of voltage-gated T-type calcium channels (Cav3.2) in paclitaxel-induced peripheral neuropathy

Pain ◽  
2017 ◽  
Vol 158 (3) ◽  
pp. 417-429 ◽  
Author(s):  
Yan Li ◽  
Claudio Esteves Tatsui ◽  
Laurence D. Rhines ◽  
Robert Y. North ◽  
Daniel S. Harrison ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Dorsal Root Ganglion ◽  
Calcium Channels ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Voltage Gated ◽  
Ganglion Neurons
Sign in / Sign up

Export Citation Format

Share Document