Response of colonic motility to dopaminergic stimulation is subverted in rats with nigrostriatal lesion: relevance to gastrointestinal dysfunctions in Parkinson's disease

2015 ◽  
Vol 27 (12) ◽  
pp. 1783-1795 ◽  
Author(s):  
G. Levandis ◽  
B. Balestra ◽  
F. Siani ◽  
V. Rizzo ◽  
C. Ghezzi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Colonic Motility ◽  
Nigrostriatal Lesion ◽  
Dopaminergic Stimulation

scholarly journals EEG Microstates Change in Response to Increase in Dopaminergic Stimulation in Typical Parkinson’s Disease Patients

2018 ◽  
Vol 12 ◽  
Author(s):  
J. Ignacio Serrano ◽  
María Dolores del Castillo ◽  
Verónica Cortés ◽  
Nuno Mendes ◽  
Aida Arroyo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopaminergic Stimulation

Continuous Dopaminergic Stimulation in Parkinson's Disease - What Have We Learned from Positron-emission Tomography?

2010 ◽  
Vol 5 (1) ◽  
pp. 22
Author(s):  
David J Brooks ◽  
Nicola Pavese ◽  
◽  
Keyword(s):  
Parkinson’S Disease ◽  
Positron Emission Tomography ◽  
Parkinson's Disease ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor ◽  
Emission Tomography ◽  
Continuous Dopaminergic Stimulation ◽  
Positron Emission ◽  
Significant Step ◽  
Dopaminergic Stimulation

The hypothesis that pulsatile stimulation of striatal dopamine receptors in Parkinson's disease (PD) induces molecular and physiological changes in basal ganglia neurons and may contribute to the development of motor complications has led to the design of therapeutic strategies that provide more continuous dopaminergic stimulation. Newer agents and drug-delivery systems, such as slow-release preparations, catechol- O-methyltransferase and monoamine oxidase inhibitor agents, apomorphine and Duodopa™infusions, represent a significant step towards less pulsatile dopaminergic administration. However, their efficacy in providing steady brain levels of dopaminergic stimulation in the short and longer term has not yet been proved in patients. This article briefly reviews and discusses the findings of published positron-emission tomography (PET) studies that support or oppose the value of continuous dopaminergic stimulation in PD. The potential future value of PET for proof of mechanism in this area is also debated.

Continuous Transdermal Dopaminergic Stimulation in Advanced Parkinson's Disease

2001 ◽  
Vol 24 (3) ◽  
pp. 163-169 ◽  
Author(s):  
Leo Verhagen Metman ◽  
Marge Gillespie ◽  
Carrie Farmer ◽  
Francesco Bibbiani ◽  
Spiridon Konitsiotis ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Advanced Parkinson’S Disease ◽  
Dopaminergic Stimulation

Effects of central dopaminergic stimulation by apomorphine on speech in Parkinson's disease

Neurology ◽  
2000 ◽  
Vol 54 (2) ◽  
pp. 458-458 ◽  
Author(s):  
K. Kompoliti ◽  
Q. E. Wang ◽  
C. G. Goetz ◽  
S. Leurgans ◽  
R. Raman
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopaminergic Stimulation

A nigro‐vagal pathway controls colonic motility and may be impaired in a model of environmental Parkinson’s disease

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Giorgia Nanni ◽  
R. Alberto Travagli
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Colonic Motility ◽  
Vagal Pathway
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