OPTIMAL CONTROL INTERVENTION STRATEGIES USING AN N-PATCH WATERBORNE DISEASE MODEL

2016 ◽  
Vol 29 (4) ◽  
pp. 499-519 ◽  
Author(s):  
O. C. COLLINS ◽  
K. J. DUFFY
2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Obiora Cornelius Collins ◽  
Kevin Jan Duffy

A mathematical model is formulated that captures the essential dynamics of waterborne disease transmission under the assumption of a homogeneously mixed population. The important mathematical features of the model are determined and analysed. The model is extended by introducing control intervention strategies such as vaccination, treatment, and water purification. Mathematical analyses of the control model are used to determine the possible benefits of these control intervention strategies. Optimal control theory is utilized to determine how to reduce the spread of a disease with minimum cost. The model is validated using a cholera outbreak in Haiti.


2015 ◽  
Vol 269 ◽  
pp. 86-93 ◽  
Author(s):  
O.C. Collins ◽  
Suzanne L. Robertson ◽  
K.S. Govinder

2019 ◽  
Vol 356 (7) ◽  
pp. 3991-4025 ◽  
Author(s):  
Ravi P. Agarwal ◽  
Qaisar Badshah ◽  
Ghaus ur Rahman ◽  
Saeed Islam

2018 ◽  
Vol 2018 ◽  
pp. 1-11
Author(s):  
Hongwu Tan ◽  
Hui Cao

We build and study the transmission dynamics of a hand-foot-mouth disease model with vaccination. The reproduction number is given, the existence of equilibria is obtained, and the global stability of disease-free equilibrium is proved by constructing the Lyapunov function. We also apply optimal control theory to the hand-foot-mouth disease model. The treatment and vaccination interventions are considered in the hand-foot-mouth disease model, and the optimal control strategies based on minimizing the cost of intervention and minimizing the number of the infected people are given. Numerical results show the usefulness of the optimization strategies.


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