Cardiac imaging by computed tomography (CT) has the unique advantage of providing a fully isotropic data set with high spatial resolution. However, the rapid motion of the heart poses substantial challenges to CT imaging. For this reason, specific techniques have been developed to increase the temporal resolution of CT imaging and to permit either image acquisition or data reconstruction in synchronization with the patient’s electrocardiogram. Next to the use of advanced scanner technology, careful patient preparation is important to avoid artefacts. This includes careful coaching and practising of the breath-hold sequence to lower the heart rate, especially when CT is used to visualize the coronary arteries. With modern scanners, radiation exposure is reasonably low and falls approximately in the range of an invasive coronary angiogram.