In situ study of cellular immune response in human cutaneous lesions caused by Leishmania (Viannia) panamensis in Panama

2020 ◽  
Author(s):  
Kadir Gonzalez ◽  
José Eduardo Calzada ◽  
Thaise Yumie Tomokane ◽  
Carmen Maria Sandoval Pacheco ◽  
Gabriela Venicia Araujo Flores ◽  
...  
Keyword(s):  
Immune Response ◽  
Cellular Immune Response ◽  
Cutaneous Lesions ◽  
In Situ Study ◽  
Cellular Immune

scholarly journals Spontaneous regional heading of extensive skin lesions in diffuse cutaneous leishmaniasis (DCL)

1995 ◽  
Vol 28 (1) ◽  
pp. 45-47 ◽  
Author(s):  
Jackson M.L. Costa ◽  
Ana Cristina R. Saldanha ◽  
Conceição de Maria P. e Silva ◽  
Maria dos Remédios F.C. Branco ◽  
Aldina Barrai ◽  
...  
Keyword(s):  
Immune Response ◽  
Cutaneous Leishmaniasis ◽  
Cellular Immune Response ◽  
Skin Lesions ◽  
In Situ Characterization ◽  
Spontaneous Healing ◽  
Specific Therapy ◽  
Mucosal Involvement ◽  
Cellular Immune

The authors report a case of diffuse cutaneous leishmaniasis, with longstanding evolution and presenting with diffuse infiltrated lesions rich in amastigotes in the absence of mucosal involvement. In situ characterization with monoclonal antibodies revealed Leishmania amazonensis. Large regional lesions have presented spontaneous healing without specific therapy. Considering that DCL presents with a defect in the cellular immune response, thisfact demonstrate that this patient may develop a regional cellular immune response enough to destroy the parasites and to produce clearing of some lesions.

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