The in situ cellular immune response in BALB/c mice jejunum disseminated lymphoid tissue after stimulations withE. coli endotoxin

1980 ◽  
Vol 168 (4) ◽  
pp. 273-281
Author(s):  
V. A. Toma ◽  
J. D. Anderson
Keyword(s):  
Immune Response ◽  
Cellular Immune Response ◽  
Lymphoid Tissue ◽  
Cellular Immune

In situ study of cellular immune response in human cutaneous lesions caused by Leishmania (Viannia) panamensis in Panama

2020 ◽  
Author(s):  
Kadir Gonzalez ◽  
José Eduardo Calzada ◽  
Thaise Yumie Tomokane ◽  
Carmen Maria Sandoval Pacheco ◽  
Gabriela Venicia Araujo Flores ◽  
...  
Keyword(s):  
Immune Response ◽  
Cellular Immune Response ◽  
Cutaneous Lesions ◽  
In Situ Study ◽  
Cellular Immune

scholarly journals Spontaneous regional heading of extensive skin lesions in diffuse cutaneous leishmaniasis (DCL)

1995 ◽  
Vol 28 (1) ◽  
pp. 45-47 ◽  
Author(s):  
Jackson M.L. Costa ◽  
Ana Cristina R. Saldanha ◽  
Conceição de Maria P. e Silva ◽  
Maria dos Remédios F.C. Branco ◽  
Aldina Barrai ◽  
...  
Keyword(s):  
Immune Response ◽  
Cutaneous Leishmaniasis ◽  
Cellular Immune Response ◽  
Skin Lesions ◽  
In Situ Characterization ◽  
Spontaneous Healing ◽  
Specific Therapy ◽  
Mucosal Involvement ◽  
Cellular Immune

The authors report a case of diffuse cutaneous leishmaniasis, with longstanding evolution and presenting with diffuse infiltrated lesions rich in amastigotes in the absence of mucosal involvement. In situ characterization with monoclonal antibodies revealed Leishmania amazonensis. Large regional lesions have presented spontaneous healing without specific therapy. Considering that DCL presents with a defect in the cellular immune response, thisfact demonstrate that this patient may develop a regional cellular immune response enough to destroy the parasites and to produce clearing of some lesions.

scholarly journals In situ CUTANEOUS CELLULAR IMMUNE RESPONSE IN DOGS NATURALLY AFFECTED BY VISCERAL LEISHMANIASIS

2016 ◽  
Vol 58 (0) ◽  
Author(s):  
Claudio Nazaretian ROSSI ◽  
Thaise Yumie TOMOKANE ◽  
Luis Fábio da Silva BATISTA ◽  
Mary MARCONDES ◽  
Carlos Eduardo LARSSON ◽  
...  
Keyword(s):  
Immune Response ◽  
Visceral Leishmaniasis ◽  
Cellular Immune Response ◽  
Cellular Immune

scholarly journals In situ cellular immune response in non-ulcerated skin lesions due to Leishmania (L.) infantum chagasi infection

2021 ◽  
Author(s):  
Carmen Sandoval ◽  
Gabriela Araujo ◽  
Wilfredo Sosa ◽  
Sara Avalos ◽  
Fernando Silveira ◽  
...  
Keyword(s):  
Immune Response ◽  
T Lymphocytes ◽  
Cutaneous Leishmaniasis ◽  
Cellular Immune Response ◽  
Defense Mechanisms ◽  
Skin Lesions ◽  
Cd8 T Lymphocytes ◽  
Ifn Γ ◽  
Cellular Immune

Background Skin lesions of patients affected by non-ulcerated cutaneous leishmaniasis (NUCL) caused by L. (L.) infantum chagasi are characterized by lymphohistiocytic inflammatory infiltrate associated with epithelioid granuloma and scarce parasitism. However, the in situ cellular immune response of these patients is unclear. Therefore, the aim of the present study was to characterize the cellular immune response in the skin lesions of patients affected by NUCL. Methods Twenty biopsies were processed by immunohistochemistry using primary antibodies to T lymphocytes (CD4, CD8), NK cells, B lymphocytes, macrophages, nitric oxide synthase and interferon-gamma. Results Immunohistochemistry revealed higher expression of all cellular types and molecules (IFN-γ, iNOS) in the dermis of diseased skin compared to the skin of healthy individuals (p < 0.05). Morphometric analysis performed in the skin lesions sections showed the predominance of CD8+ T lymphocytes in the mononuclear infiltrate, followed by macrophages, mostly iNOS+, a response that could be mediated by IFN-γ. Conclusion Our study improves knowledge of the cellular immune response in non-ulcerated or atypical cutaneous leishmaniasis caused by L. (L.) infantum chagasi in Central America and pointed to the pivotal participation of CD8+ T lymphocytes in the host defense mechanisms against the parasite in patients with NUCL.

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