Age-related changes in interstitial fibrosis and germ cell degeneration of the canine testis

2018 ◽  
Vol 53 ◽  
pp. 37-43 ◽  
Author(s):  
Cholayuth Bhanmeechao ◽  
Sayamon Srisuwatanasagul ◽  
Suppawiwat Ponglowhapan
Keyword(s):  
Germ Cell ◽  
Interstitial Fibrosis ◽  
Cell Degeneration ◽  
Age Related ◽  
Germ Cell Degeneration ◽  
Age Related Changes

Germ Cell Degeneration in High-Temperature Treated Pufferfish, Takifugu rubripes

2009 ◽  
Vol 3 (4) ◽  
pp. 225-232 ◽  
Author(s):  
K.H. Lee ◽  
A. Yamaguchi ◽  
H. Rashid ◽  
K. Kadomura ◽  
S. Yasumoto ◽  
...  
Keyword(s):  
High Temperature ◽  
Germ Cell ◽  
Takifugu Rubripes ◽  
Cell Degeneration ◽  
Germ Cell Degeneration

scholarly journals Germ Cell Degeneration

2020 ◽  
Author(s):  
Keyword(s):  
Germ Cell ◽  
Cell Degeneration ◽  
Germ Cell Degeneration

Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis

Development ◽  
1998 ◽  
Vol 125 (6) ◽  
pp. 1103-1112 ◽  
Author(s):  
G.Q. Zhao ◽  
L. Liaw ◽  
B.L. Hogan
Keyword(s):  
Germ Cell ◽  
Germ Cells ◽  
Targeted Mutagenesis ◽  
Chromosome 4 ◽  
Female Reproduction ◽  
Cell Degeneration ◽  
Male Germ Cells ◽  
Morphogenetic Protein ◽  
Germ Cell Degeneration

The murine Bmp8a and Bmp8b genes are tightly linked on mouse chromosome 4 and have similar expression during reproduction. Previous studies have shown that targeted mutagenesis of Bmp8b causes male infertility due to germ cell degeneration. To investigate the function of Bmp8a, we have inactivated the gene by homologous recombination. Heterozygous and homozygous Bmp8a mutants reveal normal embryonic and postnatal development. Despite high levels of Bmp8a expression in the deciduum, homozygous mutant females have normal fertility, suggesting that the gene is not essential for female reproduction. Bmp8a and Bmp8b are expressed in similar patterns in male germ cells. Unlike homozygous Bmp8btm1 mutants, homozygous Bmp8atm1 males do not show obvious germ cell defects during the initiation of spermatogenesis. However, germ cell degeneration is observed in 47% of adult homozygous Bmp8atm1 males, establishing a role of Bmp8a in the maintenance of spermatogenesis. A small proportion of the mating homozygous Bmp8atm1 males also show degeneration of the epididymal epithelium, indicating a novel role for BMPs in the control of epididymal function.

Old age and kidneys

2008 ◽  
Vol 149 (17) ◽  
pp. 789-794 ◽  
Author(s):  
Endre Balázs ◽  
Andrea Ruszwurm ◽  
Miklós Székely ◽  
István Wittmann ◽  
Judit Nagy
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Interstitial Fibrosis ◽  
The Elderly ◽  
Tubular Atrophy ◽  
Water Excretion ◽  
Age Related ◽  
Renal Morphology ◽  
And Function ◽  
Age Related Changes

Age-related changes in renal morphology and function cannot be regarded physiological. The number of glomeruli falls, sclerotic glomeruli and aglomerular arterioles develop. Besides tubular atrophy interstitial fibrosis is often seen, and the age-related vascular changes strongly affect the kidneys. Renal blood flow and GFR decrease, without concomitant changes in se-creatinine. Disorders of tubular transport manifest mainly in salt- and water-excretion and lead to hyposthenuria. The pathogenesis of these age-related changes is not fully understood. Nevertheless, such changes impair the excretory functions and the pharmacokinetics of drugs. In real chronic renal failure other functions (erythropoietin production, vitamin-D, Ca and P metabolism) are also impaired. Due to more frequent occurrence of systemic diseases (diabetes, hypertension, etc.) in the elderly, real chronic renal failure is also more common, and various forms of acute renal failure develop more easily.

A MODIFICATION OF THE URODELE TESTIS RESULTING FROM GERM-CELL DEGENERATION

1925 ◽  
Vol 48 (3) ◽  
pp. 145-165 ◽  
Author(s):  
R. R. HUMPHREY
Keyword(s):  
Germ Cell ◽  
Cell Degeneration ◽  
Germ Cell Degeneration

Age-related changes of seminiferous tubule morphology, interstitial fibrosis and spermatogenesis in dogs

2020 ◽  
Vol 219 ◽  
pp. 106534
Author(s):  
Matteo Tesi ◽  
Giulia Lazzarini ◽  
Chiara Magliaro ◽  
Francesca Abramo ◽  
Diana Fanelli ◽  
...  
Keyword(s):  
Seminiferous Tubule ◽  
Interstitial Fibrosis ◽  
Age Related ◽  
Age Related Changes
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