scholarly journals O14‐2: Chemotherapy versus chemo‐immunotherapy as first‐line treatment in patients with extensive‐stage small‐cell lung cancer‐A systematic review and meta‐analysis

Respirology ◽  
2021 ◽  
Vol 26 (S3) ◽  
pp. 38-39
Immunotherapy ◽  
2021 ◽  
Author(s):  
Ching-Yi Chen ◽  
Wang-Chun Chen ◽  
Chao-Ming Hung ◽  
Yu-Feng Wei

This meta-analysis investigated the clinical benefits of chemo-immunotherapy in extensive-stage small-cell lung cancer (ES-SCLC). Seven randomized controlled trials with a total of 2862 patients were analyzed. Compared with chemotherapy alone, chemo-immunotherapy provided a better progression-free survival (PFS) with a hazard ratio (HR) of 0.81, p < 0.00001, and overall survival (OS) with a HR of 0.82, p < 0.0001; however, the incidence of treatment-related adverse effects (TRAEs) was significantly increased. Subgroup analyses showed that good performance status, cisplatin-based chemotherapy, without brain metastases at baseline and non-Asian populations were associated with greater benefits in OS from chemo-immunotherapy. Chemo-immunotherapy demonstrated better PFS and OS compared with chemotherapy alone as first line treatment in ES-SCLC, but additional TRAEs should be closely monitored.


2018 ◽  
Vol 10 (12) ◽  
pp. 6677-6694 ◽  
Author(s):  
Lisa M. Hess ◽  
Amy M. DeLozier ◽  
Fanni Natanegara ◽  
Xiaofei Wang ◽  
Victoria Soldatenkova ◽  
...  

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