scholarly journals A Bayesian nonparametric analysis of the 2003 outbreak of highly pathogenic avian influenza in the Netherlands

Author(s):  
Rowland G. Seymour ◽  
Theodore Kypraios ◽  
Philip D. O’Neill ◽  
Thomas J. Hagenaars
2017 ◽  
Vol 23 (12) ◽  
pp. 2050-2054 ◽  
Author(s):  
Erik Kleyheeg ◽  
Roy Slaterus ◽  
Rogier Bodewes ◽  
Jolianne M. Rijks ◽  
Marcel A.H. Spierenburg ◽  
...  

2016 ◽  
Vol 21 (38) ◽  
Author(s):  
Marjolein J Poen ◽  
Josanne H Verhagen ◽  
Ruth J Manvell ◽  
Ian Brown ◽  
Theo M Bestebroer ◽  
...  

In 2014, H5N8 clade 2.3.4.4 highly pathogenic avian influenza (HPAI) viruses of the A/Goose/Guangdong/1/1996 lineage emerged in poultry and wild birds in Asia, Europe and North America. Here, wild birds were extensively investigated in the Netherlands for HPAI H5N8 virus (real-time polymerase chain reaction targeting the matrix and H5 gene) and antibody detection (haemagglutination inhibition and virus neutralisation assays) before, during and after the first virus detection in Europe in late 2014. Between 21 February 2015 and 31 January 2016, 7,337 bird samples were tested for the virus. One HPAI H5N8 virus-infected Eurasian wigeon (Anas penelope) sampled on 25 February 2015 was detected. Serological assays were performed on 1,443 samples, including 149 collected between 2007 and 2013, 945 between 14 November 2014 and 13 May 2015, and 349 between 1 September and 31 December 2015. Antibodies specific for HPAI H5 clade 2.3.4.4 were absent in wild bird sera obtained before 2014 and present in sera collected during and after the HPAI H5N8 emergence in Europe, with antibody incidence declining after the 2014/15 winter. Our results indicate that the HPAI H5N8 virus has not continued to circulate extensively in wild bird populations since the 2014/15 winter and that independent maintenance of the virus in these populations appears unlikely.


2018 ◽  
Vol 24 (4) ◽  
pp. 770-773 ◽  
Author(s):  
Nancy Beerens ◽  
Guus Koch ◽  
Rene Heutink ◽  
Frank Harders ◽  
D.P. Edwin Vries ◽  
...  

2017 ◽  
Vol 23 (12) ◽  
pp. 1974-1981 ◽  
Author(s):  
Nancy Beerens ◽  
Rene Heutink ◽  
Saskia A. Bergervoet ◽  
Frank Harders ◽  
Alex Bossers ◽  
...  

2009 ◽  
Vol 46 (5) ◽  
pp. 971-976 ◽  
Author(s):  
D. Van Riel ◽  
J. M. A. Van Den Brand ◽  
V. J. Munster ◽  
T. M. Besteboer ◽  
R. A. M. Fouchier ◽  
...  

The largest recorded outbreak of highly pathogenic avian influenza virus of the subtype H7N7 occurred in the Netherlands in 2003. We describe the immunohistochemical and histopathologic findings of 3 chickens naturally infected during this outbreak. Influenza virus antigen occurred in endothelial cells and mononuclear cells of all tissues examined and occurred in parenchymal cells of heart, lung, kidney, pancreas, and trachea, often associated with multifocal inflammation and necrosis. These findings are consistent with the acute stage of highly pathogenic avian influenza from other subtypes. In the severely edematous wattle skin, most endothelial cells contained virus antigen, while in all other tissues virus antigen was only detected in a few endothelial cells. Virus histochemistry showed that this H7N7 virus attached to more endothelial cells in wattle skin than in other vascular beds. This might explain, at least partly, the tropism of the virus and the associated severity of lesions in this tissue.


2020 ◽  
Author(s):  
Nancy Beerens ◽  
Rene Heutink ◽  
Frank Harders ◽  
Marit Roose ◽  
Sylvia B.E. Pritz-Verschuren ◽  
...  

AbstractThe HPAI H5N8 virus detected in mute swans in the Netherlands in October 2020 shares a common ancestor with clade 2.3.4.4b viruses last detected in Egypt in 2018-2019 and has a similar genetic composition. The virus is not directly related to European H5N8 viruses detected in first half of 2020.


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