Donor‐derived human herpesvirus 8 infection with kaposi sarcoma and kaposi sarcoma inflammatory cytokine syndrome in a heart transplant recipient: a case report

Author(s):  
Antonio Russo ◽  
Laura Giovannini ◽  
Nicolina Conti ◽  
Elena Sabattini ◽  
Luca Vizioli ◽  
...  
2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
H. Benhammane ◽  
G. Mentha ◽  
E. Tschanz ◽  
O. El Mesbahi ◽  
P. Y. Dietrich

Background. Kaposi’s sarcoma (KS) in transplant recipients is about 400 to 500 times rate in the general population. It is strongly associated to Human herpesvirus-8 (HHV-8) infection which has been found in 95% of KS lesions. The optimal approach to managing posttransplantation KS is to reduce or discontinue immunosuppressive therapy but this strategy carries a risk of the acute rejection of the graft. Recently, the use of an mTOR inhibitor has added new opportunities for KS treatment and prevention.Case Report. We report a case of 24 years-old Turkish woman with visceral HHV-8-associated Kaposi's sarcoma after orthotopic liver transplantation.Conclusion. Posttransplantation KS is considered an experimental model of virus induced tumor suggesting the usefulness of HHV-8 screening in transplant recipient and donor. Therapeutic approaches are complex and require a multidisciplinary team.


Virology ◽  
2012 ◽  
Vol 433 (1) ◽  
pp. 220-225 ◽  
Author(s):  
Kristen M. Tamburro ◽  
Dongmei Yang ◽  
Jessica Poisson ◽  
Yuri Fedoriw ◽  
Debasmita Roy ◽  
...  

2008 ◽  
Vol 86 (5) ◽  
pp. 738-744 ◽  
Author(s):  
Patrizia Barozzi ◽  
Chiara Bonini ◽  
Leonardo Potenza ◽  
Michele Masetti ◽  
Gianni Cappelli ◽  
...  

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