scholarly journals Triology of Human Herpesvirus Type-8: A Rare and Fatal Case Report of Primary Effusion Lymphoma, Kaposi Sarcoma and Kaposi Sarcoma-associated Herpesvirus Inflammatory Cytokine Syndrome (KICS)

2021 ◽  
pp. 100084
Author(s):  
Shuai Wang ◽  
Lewis Steinberg ◽  
Yan Zhang ◽  
Carol Harris ◽  
Abhishek Kumar
Keyword(s):  
Case Report ◽  
Inflammatory Cytokine ◽  
Primary Effusion Lymphoma ◽  
Fatal Case ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Herpesvirus Type ◽  
Human Herpesvirus Type

scholarly journals Immunohistochemical detection of the latent nuclear antigen-1 of the human herpesvirus type 8 to differentiate cutaneous epidemic Kaposi sarcoma and its histological simulators

2013 ◽  
Vol 88 (2) ◽  
pp. 243-246 ◽  
Author(s):  
Patricia Fonseca Pereira ◽  
Tullia Cuzzi ◽  
Maria Clara Gutierrez Galhardo
Keyword(s):  
Kaposi's Sarcoma ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Nuclear Antigen ◽  
Immunohistochemical Detection ◽  
Herpesvirus Type ◽  
Human Herpesvirus Type ◽  
Skin Biopsies ◽  
Latent Nuclear Antigen

Kaposi's sarcoma is the most common neoplasia diagnosed in AIDS patients and the expression of the human herpesvirus-8 (HHV-8) latent nuclear antigen-1 has been useful for its histological diagnosis. The aim of this study is to confirm that immunohistochemistry is a valuable tool for differentiating KS from its simulators in skin biopsies of HIV patients. Immunohistochemical and histological analyses were performed in 49 Kaposi's sarcoma skin biopsies and 60 of its histological simulators. Positivity was present in the 49 Kaposi's sarcoma skin biopsies and no staining was observed in the 60 simulators analyzed, resulting in sensibility and specificity of 100%. HHV-8 immunohistochemical detection is an effective tool for diagnosing Kaposi's sarcoma, especially in early lesions in which neoplastic features are not evident. It also contributes to its histological differential diagnosis.

Anorectal melanomas do not harbour the kaposi sarcoma-associated human herpesvirus type 8 DNA

2001 ◽  
Vol 64 (1) ◽  
pp. 47-50 ◽  
Author(s):  
Burkhard M. Helmke ◽  
Martin Deichmann ◽  
Herwart F. Otto
Keyword(s):  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Herpesvirus Type ◽  
Human Herpesvirus Type

Primary Effusion Lymphoma Cell Lines Harbouring Human Herpesvirus Type-8

2000 ◽  
Vol 36 (5-6) ◽  
pp. 447-456 ◽  
Author(s):  
Antonino Carbone ◽  
Anna M. Cilia ◽  
Annunziata Gloghini ◽  
Daniela Capello ◽  
Tiziana Perin ◽  
...  
Keyword(s):  
Cell Lines ◽  
Primary Effusion Lymphoma ◽  
Human Herpesvirus ◽  
Lymphoma Cell ◽  
Herpesvirus Type ◽  
Primary Effusion Lymphoma Cell ◽  
Human Herpesvirus Type

Primary Effusion Lymphoma Cells Undergoing Human Herpesvirus Type 8 Productive Infection Produce C-Type Retroviral Particles

2008 ◽  
Vol 21 (4) ◽  
pp. 999-1006 ◽  
Author(s):  
A. Tinari ◽  
F. Superti ◽  
M.G. Ammendolia ◽  
C. Chiozzini ◽  
C. Hohenadl ◽  
...  
Keyword(s):  
Particle Production ◽  
Phorbol Esters ◽  
Primary Effusion Lymphoma ◽  
Human Herpesvirus ◽  
Endogenous Retroviruses ◽  
Productive Infection ◽  
Late Gene Expression ◽  
Herpesvirus Type ◽  
Human Herpesvirus Type ◽  
Type Particle

Primary effusion lymphomas (PELs) are invariably infected by the human herpesvirus 8 (HHV8) that is present in most PEL cells as latent virus but replicates in a subset of permissive cells to produce infectious progeny. Here we show that productively infected PEL cells release C-type retrovirus-like particles encoding an Mn++-dependent RT activity, which is typical of endogenous retroviruses. Strikingly, C-type particles are produced only in cells showing advanced HHV8 morphogenesis. Phorbol esters, which induce productive HHV8 replication and morphogenesis in PEL cells, increase RLP production. Phosphonoacetic acid, a blocker of HHV8 late gene expression, inhibits the production of C-type particles, whereas neutralizing anti-αIFN antibodies, which are known to increase HHV8 assembly, increases C-type particle production. These data suggest that factors expressed in advanced stages of HHV8 reactivation support endogenous C-type particle morphogenesis in PEL cells.

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