scholarly journals Pre‐hospital transfusion of red blood cells in civilian trauma patients: what's next?

2018 ◽  
Vol 28 (6) ◽  
pp. 457-457
Author(s):  
M. L. Tonglet ◽  
F. Swerts ◽  
P. Y. Mathonet ◽  
D. Moens ◽  
V. D'Orio ◽  
...  
2017 ◽  
Vol 28 (4) ◽  
pp. 277-283 ◽  
Author(s):  
M. Rehn ◽  
A. E. Weaver ◽  
S. Eshelby ◽  
J. Røislien ◽  
D. J. Lockey

Author(s):  
Yuk Ming Liu ◽  
Kathryn Butler

This chapter provides a summary of the landmark study known as the PROPPR trial. How effective and safe is rapid transfusion of patients with severe traumatic hemorrhage using plasma, platelets, and red blood cells in a 1:1:1 ratio compared to a 1:1:2 ratio? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case. A growing body of literature suggests that massive transfusion protocols confer mortality benefits for trauma patients in hemorrhagic shock; however, such protocols still require standardization. In the PROPPR trial, there was suggestion of improved hemostasis and less death from exsanguinations with a 1:1:1 transfusion ratio versus a 1:1:2 approach; however, further trials are warranted.


2014 ◽  
Vol 219 (4) ◽  
pp. e190 ◽  
Author(s):  
Greg Magee ◽  
Kenji Inaba ◽  
Konstantinos Chouliaras ◽  
Aaron Strumwasser ◽  
Kazuhide Matsushima ◽  
...  

Hematology ◽  
2010 ◽  
Vol 2010 (1) ◽  
pp. 463-464 ◽  
Author(s):  
Timothy Hannon

Abstract The use of high ratios of red blood cells to platelets and plasma in trauma resuscitation protocols is quickly gaining favor in civilian trauma centers. The use of higher ratios of coagulation factors to red blood cells has been shown to improve outcomes in both military and civilian centers, but does the evidence support the use of a 1:1:1 ratio, as has been suggested? There is growing evidence that the use of such high ratios may be excessive and potentially harmful, and there has not been enough emphasis on the other components of evidence-based “damage control” resuscitation.


2014 ◽  
Vol 77 (5) ◽  
pp. 674-678 ◽  
Author(s):  
Satbir K. Dhillon ◽  
Mindy L. Houck ◽  
Donald H. Jenkins ◽  
Jordan K. Rosedahl ◽  
William S. Harmsen ◽  
...  

2009 ◽  
Vol 67 (1) ◽  
pp. 29-32 ◽  
Author(s):  
Laszlo N. Kiraly ◽  
Samantha Underwood ◽  
Jerome A. Differding ◽  
Martin A. Schreiber

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