Ultra‐high α‐linolenic acid accumulating developmental defective embryo was rescued by lysophosphatidic acid acyltransferase 2

2020 ◽  
Vol 103 (6) ◽  
pp. 2151-2167
Author(s):  
Yongtai Yin ◽  
Zhenyi Guo ◽  
Kang Chen ◽  
Tian Tian ◽  
Jiajun Tan ◽  
...  
Keyword(s):  
Linolenic Acid ◽  
Lysophosphatidic Acid ◽  
Lysophosphatidic Acid Acyltransferase

Diamino-C,N-diarylpyridine Positional Isomers as Inhibitors of Lysophosphatidic Acid Acyltransferase-β.

ChemInform ◽  
2006 ◽  
Vol 37 (4) ◽  
Author(s):  
Feng Hong ◽  
David Hollenback ◽  
Jack W. Singer ◽  
Peter Klein
Keyword(s):  
Lysophosphatidic Acid ◽  
Positional Isomers ◽  
Lysophosphatidic Acid Acyltransferase

scholarly journals Lysophosphatidic Acid Acyltransferase β (LPAATβ) Promotes the Tumor Growth of Human Osteosarcoma

PLoS ONE ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. e14182 ◽  
Author(s):  
Farbod Rastegar ◽  
Jian-Li Gao ◽  
Deana Shenaq ◽  
Qing Luo ◽  
Qiong Shi ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Lysophosphatidic Acid ◽  
Human Osteosarcoma ◽  
Lysophosphatidic Acid Acyltransferase

Abstract 1854: Lysophosphatidic Acid Acyltransferase-Beta contributes to proliferation and anchorage-independent growth in pancreatic adenocarcinoma

2012 ◽  
Author(s):  
Michelle Blaskovich ◽  
Harsukh Gevariya ◽  
Nicholas J. Lawrence ◽  
Saïd M. Sebti ◽  
Gregory Springett
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Lysophosphatidic Acid ◽  
Anchorage Independent Growth ◽  
Lysophosphatidic Acid Acyltransferase

Abstract 2470: Identification and evaluation of small molecule inhibitors of lysophosphatidic acid acyltransferase-beta.

2013 ◽  
Author(s):  
Michelle A. Blaskovich ◽  
Harsukh Gevariya ◽  
Nicholas J. Lawrence ◽  
Saïd Sebti ◽  
Gregory Springett
Keyword(s):  
Small Molecule ◽  
Lysophosphatidic Acid ◽  
Small Molecule Inhibitors ◽  
Lysophosphatidic Acid Acyltransferase

scholarly journals Characterization of mouse lysophosphatidic acid acyltransferase 3: an enzyme with dual functions in the testis,

2008 ◽  
Vol 50 (5) ◽  
pp. 860-869 ◽  
Author(s):  
Koichi Yuki ◽  
Hideo Shindou ◽  
Daisuke Hishikawa ◽  
Takao Shimizu
Keyword(s):  
Lysophosphatidic Acid ◽  
Lysophosphatidic Acid Acyltransferase ◽  
Dual Functions

scholarly journals Human Lysophosphatidic Acid Acyltransferase

1997 ◽  
Vol 272 (32) ◽  
pp. 20299-20305 ◽  
Author(s):  
Christine Eberhardt ◽  
Patrick W. Gray ◽  
Larry W. Tjoelker
Keyword(s):  
Lysophosphatidic Acid ◽  
Lysophosphatidic Acid Acyltransferase

scholarly journals CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase

2009 ◽  
Vol 51 (4) ◽  
pp. 709-719 ◽  
Author(s):  
Gabriela Montero-Moran ◽  
Jorge M. Caviglia ◽  
Derek McMahon ◽  
Alexis Rothenberg ◽  
Vidya Subramanian ◽  
...  
Keyword(s):  
Lysophosphatidic Acid ◽  
Coenzyme A ◽  
Lysophosphatidic Acid Acyltransferase

scholarly journals YPR139c/LOA1encodes a novel lysophosphatidic acid acyltransferase associated with lipid droplets and involved in TAG homeostasis

2012 ◽  
Vol 23 (2) ◽  
pp. 233-246 ◽  
Author(s):  
Sophie Ayciriex ◽  
Marina Le Guédard ◽  
Nadine Camougrand ◽  
Gisèle Velours ◽  
Mario Schoene ◽  
...  
Keyword(s):  
Lysophosphatidic Acid ◽  
Lipid Droplets ◽  
Neutral Lipids ◽  
In Vitro Assays ◽  
Metabolic Labeling ◽  
Lysophosphatidic Acid Acyltransferase ◽  
Escherichia Coli Cells ◽  
Type Strains

For many years, lipid droplets (LDs) were considered to be an inert store of lipids. However, recent data showed that LDs are dynamic organelles playing an important role in storage and mobilization of neutral lipids. In this paper, we report the characterization of LOA1 (alias VPS66, alias YPR139c), a yeast member of the glycerolipid acyltransferase family. LOA1 mutants show abnormalities in LD morphology. As previously reported, cells lacking LOA1 contain more LDs. Conversely, we showed that overexpression results in fewer LDs. We then compared the lipidome of loa1Δ mutant and wild-type strains. Steady-state metabolic labeling of loa1Δ revealed a significant reduction in triacylglycerol content, while phospholipid (PL) composition remained unchanged. Interestingly, lipidomic analysis indicates that both PLs and glycerolipids are qualitatively affected by the mutation, suggesting that Loa1p is a lysophosphatidic acid acyltransferase (LPA AT) with a preference for oleoyl-CoA. This hypothesis was tested by in vitro assays using both membranes of Escherichia coli cells expressing LOA1 and purified proteins as enzyme sources. Our results from purification of subcellular compartments and proteomic studies show that Loa1p is associated with LD and active in this compartment. Loa1p is therefore a novel LPA AT and plays a role in LD formation.

Diamino-C,N-diarylpyridine positional isomers as inhibitors of lysophosphatidic acid acyltransferase-β

2005 ◽  
Vol 15 (21) ◽  
pp. 4703-4707 ◽  
Author(s):  
Feng Hong ◽  
David Hollenback ◽  
Jack W. Singer ◽  
Peter Klein
Keyword(s):  
Lysophosphatidic Acid ◽  
Positional Isomers ◽  
Lysophosphatidic Acid Acyltransferase
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