scholarly journals Principles of Virus Uncoating: Cues and the Snooker Ball

Traffic ◽  
2016 ◽  
Vol 17 (6) ◽  
pp. 569-592 ◽  
Author(s):  
Yohei Yamauchi ◽  
Urs F. Greber
Keyword(s):  
Virus Uncoating

scholarly journals Involvement of proteases in porcine reproductive and respiratory syndrome virus uncoating upon internalization in primary macrophages

2008 ◽  
Vol 39 (6) ◽  
pp. 55 ◽  
Author(s):  
Gerald M. Misinzo ◽  
Peter L. Delputte ◽  
Hans J. Nauwynck
Keyword(s):  
Respiratory Syndrome Virus ◽  
Virus Uncoating

scholarly journals Drifting Motions of the Adenovirus Receptor CAR and Immobile Integrins Initiate Virus Uncoating and Membrane Lytic Protein Exposure

2011 ◽  
Vol 10 (2) ◽  
pp. 105-117 ◽  
Author(s):  
Christoph J. Burckhardt ◽  
Maarit Suomalainen ◽  
Philipp Schoenenberger ◽  
Karin Boucke ◽  
Silvio Hemmi ◽  
...  
Keyword(s):  
Adenovirus Receptor ◽  
Virus Uncoating

Examination of Potential Inhibitors of Hepatitis A Virus Uncoating

Intervirology ◽  
1998 ◽  
Vol 41 (6) ◽  
pp. 261-271 ◽  
Author(s):  
Naomi E. Bishop
Keyword(s):  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Potential Inhibitors ◽  
Virus Uncoating

scholarly journals DNA virus uncoating

Virology ◽  
2015 ◽  
Vol 479-480 ◽  
pp. 578-590 ◽  
Author(s):  
Samuel Kilcher ◽  
Jason Mercer
Keyword(s):  
Dna Virus ◽  
Virus Uncoating

Rimantadine hydrochloride blocks the second step of influenza virus uncoating

1980 ◽  
Vol 66 (3) ◽  
pp. 275-282 ◽  
Author(s):  
A. G. Bukrinskaya ◽  
N. K. Vorkunova ◽  
R. A. Narmanbetova
Keyword(s):  
Influenza Virus ◽  
Second Step ◽  
Rimantadine Hydrochloride ◽  
Virus Uncoating

scholarly journals Low Temperature and Pressure Stability of Picornaviruses: Implications for Virus Uncoating

1999 ◽  
Vol 76 (3) ◽  
pp. 1270-1279 ◽  
Author(s):  
Andréa C. Oliveira ◽  
Daniella Ishimaru ◽  
Rafael B. Gonçalves ◽  
Thomas J. Smith ◽  
Peter Mason ◽  
...  
Keyword(s):  
Low Temperature ◽  
Pressure Stability ◽  
Temperature And Pressure ◽  
Virus Uncoating

scholarly journals Requirement for Vacuolar H+-ATPase Activity and Ca2+ Gradient during Entry of Rotavirus into MA104 Cells

2002 ◽  
Vol 76 (24) ◽  
pp. 13083-13087 ◽  
Author(s):  
Maria Elena Chemello ◽  
Olga Carolina Aristimuño ◽  
Fabián Michelangeli ◽  
Marie-Christine Ruiz
Keyword(s):  
Atpase Activity ◽  
Virus Entry ◽  
Significant Inhibition ◽  
Extracellular Calcium ◽  
Membrane Permeabilization ◽  
Bafilomycin A1 ◽  
Virus Binding ◽  
Critical Step ◽  
Virus Uncoating

ABSTRACT The mechanism by which rotavirus and other nonenveloped viruses enter the cell is still not clear. We have proposed an endocytosis model where the critical step for virus uncoating and membrane permeabilization is the decrease in Ca2+ concentration in the endosome. In this paper, we monitored rotavirus entry by measuring α-sarcin-rotavirus coentry and infectivity in MA104 cells. The participation of endocytosis, acidification, and endosomal Ca2+ concentration on virus entry was studied by inhibiting the endosomal H+-ATPase with bafilomycin A1 and/or increasing the extracellular calcium reservoir by addition of 10 mM CaEGTA. Rotavirus-α-sarcin coentry was inhibited by bafilomycin A1 and by addition of 10 mM CaEGTA. These effects were additive. These substances induced a significant inhibition of infectivity without affecting virus binding and postentry steps. These results are compatible with the interpretation that bafilomycin A1 and CaEGTA block rotavirus penetration from the endosome into the cytoplasm and support our hypothesis of a Ca2+-dependent endocytosis model.

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