This work of applied mathematics with interfaces in bio-physics focuses on the shape identification and numerical modelisation of a single red blood cell shape. The purpose of this work is to provide a quantitative method for interpreting experimental observations of the red blood cell shape under microscopy. In this paper we give a new formulation based on classical theory of geometric shape minimization which assumes that the curvature energy with additional constraints controls the shape of the red blood cell. To minimize this energy under volume and area constraints, we propose a new hybrid algorithm which combines Particle Swarm Optimization (PSO), Gravitational Search (GSA) and Neural Network Algorithm (NNA). The results obtained using this new algorithm agree well with the experimental results given by Evans et al. (8) especially for sphered and biconcave shapes.
Shape matters: the effect of red blood cell shape on perfusion of an artificial microvascular network
