Donor organ distribution according to urgency of need or outcome maximization in liver transplantation. A questionnaire survey among patients and medical staff

Abstract Objectives This study investigated the psychological status of patients and staff, and the implementation of preventative measures in hemodialysis centers in Guangdong province, China, during the 2019 novel coronavirus disease (COVID-19) pandemic. Methods An electronic questionnaire survey was carried out anonymously between March 28 and April 3, 2020. All of the 516 hemodialysis centers registered in Guangdong province were invited to participate in the survey. The questionnaires were designed to investigate the psychological status of hemodialysis patients and general staff members (doctors, nurses, technicians, and other staff), and to address the implementation of preventative measures for administrators (directors or head nurses) of the hemodialysis centers. Results A total of 1782 patients, 3400 staff, and 420 administrators voluntarily participated in this survey. Patients living in rural areas reported a higher incidence of severe anxiety compared to those living in other areas (in rural areas, towns, and cities, the incidence rate was 17.0%, 9.0%, and 8.9%, respectively, P < 0.001). Medical staff were less likely to worry about being infected than non-medical staff (13.1% vs 30.3%, respectively, P < 0.001). With respect to the implementation of preventative measures, hemodialysis centers in general hospitals outperformed stand-alone blood purification centers, while tertiary hospitals outperformed hospitals of other levels. However, restrictions regarding the admission of non-resident patients were lower in tertiary hospitals than in other hospitals. In this situation, only one patient imported from Hubei province was diagnosed with COVID-19. Conclusions COVID-19 did not significantly affect the psychological status of most patients and medical staff members. Due to the implementation of comprehensive preventative measures, there were no cluster outbreaks of COVID-19 in hemodialysis centers. This provincial-level survey may provide referential guidance for other countries and regions that are experiencing a similar pandemic.

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Absence of toll-like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model

Liver Transplantation ◽

10.1002/lt.21251 ◽

2007 ◽

Vol 13 (10) ◽

pp. 1435-1443 ◽

Cited By ~ 80

Author(s):

Xiu-Da Shen ◽

Bibo Ke ◽

Yuan Zhai ◽

Feng Gao ◽

Sei-Ichiro Tsuchihashi ◽

...

Keyword(s):

Liver Transplantation ◽

Reperfusion Injury ◽

Ischemia And Reperfusion ◽

Toll Like Receptor ◽

Donor Organ ◽

Ischemia And Reperfusion Injury ◽

Toll Like Receptor 4 ◽

Tlr4 Signaling ◽

Murine Liver ◽

Transplantation Model

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Tomorrow’s challenge in liver transplantation: diminishing the imbalance between donor organ availability and need

Gut ◽

10.1136/gut.43.5.728-h ◽

1998 ◽

Vol 43 (5) ◽

pp. 728.8-728

Author(s):

E M YOSHIDA ◽

S W CHUNG

Keyword(s):

Liver Transplantation ◽

Donor Organ

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An Overview of Current Status, Recent Techniques and Challenges of Liver Transplantation

International Journal of Applied Sciences and Biotechnology ◽

10.3126/ijasbt.v6i2.20417 ◽

2018 ◽

Vol 6 (2) ◽

pp. 67-74

Author(s):

Bharata Regmi ◽

Manoj Kumar Shah

Keyword(s):

Liver Transplantation ◽

Liver Disease ◽

Deceased Donor ◽

Current Status ◽

Organ Shortage ◽

Donor Organ ◽

Donor Liver ◽

Donor Liver Transplantation ◽

Split Liver

A liver transplantation (LT) is a surgical procedure that removes a liver that no longer functions properly and replaces it with a healthy liver from a living or deceased donor. It is a viable treatment option for end-stage liver disease and acute liver failure. The most commonly used technique is orthotopic transplantation or deceased donor liver transplantation (DDLT) in which the native liver is removed and replaced by the donor organ in the same anatomic location as the original liver. Ongoing challenges of LT include those concerning donor organ shortages, recipients with more advanced disease at transplant, growing need for transplantation, side effects associated with long-term immunosuppression, toxicities and obesity. Organ shortage has become the most vexing problem in LT, with 10–25% of patients dying while awaiting transplantation. Different ideas has been evolved like living donor liver transplantation (LDLT), marginal donor liver transplantation (MDLT) and split liver transplantation (SLT) to overcome the growing problem of organ shortage. These techniques are becoming very important in an attempt to narrow the gap between demand and supply of organs. The advances in surgical and anaesthetic techniques, greater understanding of the physiological, haematological, biochemical, microbiological and immunological changes in liver disease and transplantation allowed a multidisciplinary approach that led to better outcomes. These changes, coupled with more effective immunosuppressive and anti-microbial agents and improvements in patient and donor selection, mean that now liver replacement is a routine procedure with excellent long term outcomes.Int. J. Appl. Sci. Biotechnol. Vol 6(2): 67-74

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