Indications for use and complications associated with canine plasma products in 170 patients

Summary1. Aromatic diamidines which are potent inhibitors of trypsin possess a marked inhibitory effect on the clotting activity of human thrombin and on the prothrombin time and partial thromboplastin time of human plasma. They also block the contact activation phase of the coagulation process. The strongest inhibitor among the compounds tested was M & B 4596 which was followed in second place by pentamidine.2. Pentamidine was 10 times more active than ε-ACA in impeding streptokinase-induced lysis of human plasma clots. It was 100-200 times stronger than ε-ACA in inhibiting the activation of bovine plasminogen by activators formed from the interaction between streptokinase and either human plasmin(ogen) or human plasma.3. The prothrombin time and partial thromboplastin time of canine plasma were less susceptible to inhibition by pentamidine than the same tests on human plasma. Clot lysis in the canine system was inhibited by pentamidine to a similar degree as in the human system. After intravenous injection of pentamidine in the dog there occurred the expected prolongation of the partial thromboplastin time and of the clot lysis time.

Download Full-text

Antibody to antihemophilic factor and its lack of reaction with hemophilic plasma

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1965.208.3.499 ◽

1965 ◽

Vol 208 (3) ◽

pp. 499-507 ◽

Cited By ~ 6

Author(s):

William D. McLester ◽

Robert H. Wagner

Keyword(s):

Amino Acids ◽

Human Plasma ◽

Measurable Effect ◽

Rabbit Plasma ◽

Canine Plasma ◽

Inhibitor Titer ◽

Antihemophilic Factor ◽

Immune Rabbit

A partially purified preparation of canine antihemophilic factor was obtained utilizing amino acids as precipitating agents. This AHF preparation was used as the antigen in an immunologic investigation of canine hemophilia. Plasma from rabbits immunized with this preparation contained antibodies which inhibited the coagulation of normal canine plasma. The immune rabbit plasma inhibited AHF activity but had no measurable effect on any other procoagulant. Neither canine hemophilic plasma nor fractions prepared from canine hemophilic plasma contained an antigen capable of neutralizing the inhibitor (no cross-reacting material). The inhibitor titer was inversely proportional to the amount of added AHF in the form of a fraction of normal canine plasma. The inhibitor cross-reacted with human plasma AHF, but not with porcine, bovine, or rabbit AHF. The results of these studies are interpreted as providing further evidence that hemophilia, specifically canine hemophilia, is due to the failure of production of the antihemophilic factor.

Download Full-text

Indications for use and cost-effectiveness of pathogen-reduced ABO-universal plasma

Current Opinion in Hematology ◽

10.1097/moh.0b013e32831366d3 ◽

2008 ◽

Vol 15 (6) ◽

pp. 612-617 ◽

Cited By ~ 21

Author(s):

Bjarte G Solheim ◽

Rangini Chetty ◽

Oystein Flesland

Keyword(s):

Cost Effectiveness ◽

Indications For Use

Download Full-text

SS28. Long-Term Survival After Endovascular Repair and Open Repair in Patients With Anatomy Outside Endovascular Repair Indications for Use Criteria

Journal of Vascular Surgery ◽

10.1016/j.jvs.2018.03.364 ◽

2018 ◽

Vol 67 (6) ◽

pp. e238

Author(s):

Philippe Charbonneau ◽

Christine Herman ◽

Kiattisak Hongku ◽

Mohammed Habib ◽

Luc Dubois ◽

...

Keyword(s):

Endovascular Repair ◽

Open Repair ◽

Term Survival ◽

Long Term Survival ◽

Indications For Use

Download Full-text

LC-ESI-MS Determination of Bilobalide and Ginkgolides in Canine Plasma

Chromatographia ◽

10.1365/s10337-005-0671-z ◽

2005 ◽

Vol 63 (1-2) ◽

pp. 53-58 ◽

Cited By ~ 7

Author(s):

Jingling Tang ◽

Jin Sun ◽

Yinghua Sun ◽

Fude Cui ◽

Zhonggui He

Keyword(s):

Esi Ms ◽

Canine Plasma

Download Full-text

In defense of apical plastics

Kazan medical journal ◽

10.17816/kazmj50508 ◽

1935 ◽

Vol 31 (3-4) ◽

pp. 421-425

Author(s):

N. V. Antelava

Keyword(s):

Surgical Techniques ◽

Periodical Press ◽

Indications For Use

If I am currently advocating top thoracoplasty on the pages of the periodical press, which seems to have already gained recognition abroad, it is only because there are few people in our Union who do this operation, and some Phthisians and surgeons are biased towards it. Meanwhile, top thoracoplasty has its own history, certain surgical techniques and strict indications for use.

Download Full-text