Red blood cell storage duration and peri‐operative outcomes in paediatric cardiac surgery

Vox Sanguinis ◽  
2021 ◽  
Author(s):  
Asif Padiyath ◽  
Brian D. Lo ◽  
Chin Siang Ong ◽  
Dheeraj Goswami ◽  
Diana A. Steppan ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Storage Duration ◽  
Operative Outcomes ◽  
Paediatric Cardiac Surgery ◽  
Cell Storage

Effect of Red Blood Cell Storage Duration on Outcome After Paediatric Cardiac Surgery: A Prospective Observational Study

2019 ◽  
Vol 28 (5) ◽  
pp. 784-791 ◽  
Author(s):  
Arvind Kumar Bishnoi ◽  
Pankaj Garg ◽  
Kartik Patel ◽  
Chandrasekaran Ananthanarayanan ◽  
Ritesh Shah ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Observational Study ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Prospective Observational Study ◽  
Storage Duration ◽  
Paediatric Cardiac Surgery ◽  
Cell Storage

Effect of red blood cell storage duration on major postoperative complications in cardiac surgery: A randomized trial

2020 ◽  
Vol 160 (6) ◽  
pp. 1505-1514.e3 ◽  
Author(s):  
Colleen G. Koch ◽  
Daniel I. Sessler ◽  
Andra E. Duncan ◽  
Edward J. Mascha ◽  
Liang Li ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Postoperative Complications ◽  
Blood Cell ◽  
Randomized Trial ◽  
Red Blood Cell ◽  
Storage Duration ◽  
Cell Storage

scholarly journals The impact of red blood cell storage duration on tissue oxygenation in cardiac surgery

2017 ◽  
Vol 153 (3) ◽  
pp. 610-619.e2 ◽  
Author(s):  
Christopher P. Stowell ◽  
Glenn Whitman ◽  
Suzanne Granger ◽  
Hernando Gomez ◽  
Susan F. Assmann ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Tissue Oxygenation ◽  
Storage Duration ◽  
The Impact ◽  
Cell Storage

scholarly journals Red Blood Cell Storage Duration Is Associated with Various Clinical Outcomes in Pediatric Cardiac Surgery

2014 ◽  
Vol 41 (2) ◽  
pp. 6-6 ◽  
Author(s):  
Matthias Redlin ◽  
Helmut Habazettl ◽  
Helge Schoenfeld ◽  
Marian Kukucka ◽  
Wolfgang Boettcher ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Cell ◽  
Clinical Outcomes ◽  
Red Blood Cell ◽  
Pediatric Cardiac Surgery ◽  
Storage Duration ◽  
Cell Storage

scholarly journals Potential consequences of the red blood cell storage lesion on cardiac electrophysiology

2020 ◽  
Author(s):  
Marissa Reilly ◽  
Chantal Bruno ◽  
Tomas Prudencio ◽  
Nina Ciccarelli ◽  
Devon Guerrelli ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Large Volume ◽  
Cardiac Electrophysiology ◽  
Blood Products ◽  
Storage Duration ◽  
Storage Lesion ◽  
Biochemical Alterations ◽  
Cell Storage

AbstractThe red blood cell (RBC) storage lesion is a series of morphological, functional and metabolic changes that RBCs undergo following collection, processing and refrigerated storage for clinical use. Since the biochemical attributes of the RBC unit shifts with time, transfusion of older blood products may contribute to cardiac complications, including hyperkalemia and cardiac arrest. We measured the direct effect of storage age on cardiac electrophysiology and compared with hyperkalemia, a prominent biomarker of storage lesion severity. Donor RBCs were processed using standard blood banking techniques. The supernatant was collected from RBC units (sRBC), 7-50 days post-donor collection, for evaluation using Langendorff-heart preparations (rat) or human stem-cell derived cardiomyocytes. Cardiac parameters remained stable following exposure to ‘fresh’ sRBC (day 7: 5.9+0.2 mM K+), but older blood products (day 40: 9.7+0.4 mM K+) caused bradycardia (baseline: 279±5 vs day 40: 216±18 BPM), delayed sinus node recovery (baseline: 243±8 vs day 40: 354±23 msec), and increased the effective refractory period of the atrioventricular node (baseline: 77+2 vs day 40: 93+7 msec) and ventricle (baseline: 50+3 vs day 40: 98+10 msec) in perfused hearts. Beating rate was also slowed in human cardiomyocytes after exposure to older sRBC (−75+9%, day 40 vs control). Similar effects on automaticity and electrical conduction were observed with hyperkalemia (10-12 mM K+). This is the first study to demonstrate that ‘older’ blood products directly impact cardiac electrophysiology, using experimental models. These effects are likely due to biochemical alterations in the sRBC that occur over time, including, but not limited to hyperkalemia. Patients receiving large volume and/or rapid transfusions may be sensitive to these effects.New & noteworthyWe demonstrate that red blood cell storage duration time can have downstream effects on cardiac electrophysiology, likely due to biochemical alterations in the blood product. Hyperkalemia and cardiac arrest have been reported following blood transfusions, but this is the first experimental study to show a direct correlation between storage duration and cardiac function. Infant and pediatric patients, and those receiving large volume and/or rapid transfusions may be sensitive to these effects.

Red blood cell storage is associated with length of stay and renal complications after cardiac surgery

Transfusion ◽  
2011 ◽  
Vol 51 (11) ◽  
pp. 2286-2294 ◽  
Author(s):  
Julie Sanders ◽  
Sanjiv Patel ◽  
Jackie Cooper ◽  
Jennifer Berryman ◽  
Daniel Farrar ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Length Of Stay ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Renal Complications ◽  
Cell Storage

scholarly journals Red blood cell storage duration is not associated with clinical outcomes for acute chest syndrome in children with sickle cell disease

Transfusion ◽  
2015 ◽  
Vol 55 (11) ◽  
pp. 2714-2721 ◽  
Author(s):  
Melanie E. Fields ◽  
Monica L. Hulbert ◽  
Ling Chen ◽  
Ari N. Berlin ◽  
Ron Jackups ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Blood Cell ◽  
Clinical Outcomes ◽  
Sickle Cell ◽  
Red Blood Cell ◽  
Acute Chest Syndrome ◽  
Cell Disease ◽  
Storage Duration ◽  
Cell Storage

Red blood cell storage duration and mortality in patients undergoing percutaneous coronary intervention

2010 ◽  
Vol 159 (5) ◽  
pp. 876-881 ◽  
Author(s):  
Simon D. Robinson ◽  
Christian Janssen ◽  
Eric B. Fretz ◽  
Brian Berry ◽  
Alex J. Chase ◽  
...  
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Coronary Intervention ◽  
Storage Duration ◽  
Percutaneous Coronary ◽  
Cell Storage

Effects of packed red blood cell storage duration on post-transfusion clinical outcomes: a meta-analysis and systematic review

2015 ◽  
Vol 41 (12) ◽  
pp. 2087-2097 ◽  
Author(s):  
Monica Suet Ying Ng ◽  
Angela Suet Yeung Ng ◽  
Jessica Chan ◽  
John-Paul Tung ◽  
John Francis Fraser
Keyword(s):  
Systematic Review ◽  
Blood Cell ◽  
Clinical Outcomes ◽  
Red Blood Cell ◽  
Meta Analysis ◽  
Storage Duration ◽  
Cell Storage
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