Genetically engineered pig kidney transplantation in a brain‐dead human subject

2021 ◽  
Author(s):  
David K.C. Cooper
Keyword(s):  
Kidney Transplantation ◽  
Human Subject ◽  
Genetically Engineered ◽  
Pig Kidney ◽  
Brain Dead

scholarly journals Bringing Home The Bacon: Update on The State of Kidney Xenotransplantation

2018 ◽  
Vol 45 (1-3) ◽  
pp. 254-259 ◽  
Author(s):  
David K.C. Cooper ◽  
H. Iwase ◽  
L. Wang ◽  
T. Yamamoto ◽  
Qi Li ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Kidney Transplantation ◽  
Graft Survival ◽  
Cellular Response ◽  
Genetic Manipulation ◽  
Immunosuppressive Agents ◽  
Cross Reactivity ◽  
Genetically Engineered ◽  
Kidney Graft ◽  
Pig Kidney

Background: There is a continuing critical shortage of organs from deceased human donors for transplantation, particularly for patients awaiting kidney transplantation. Efforts are being made to resolve the donor kidney shortage by the transplantation of kidneys from genetically-engineered pigs. Summary: This review outlines the pathobiological barriers to pig organ xenotransplantation in primates, which include (i) antibody-dependent complement-mediated rejection, (ii) a T cell-mediated elicited antibody and cellular response, (iii) coagulation dysregulation between pigs and primates, and (iv) a persistent inflammatory response. As a result of increasing genetic manipulation of the pig and the introduction of novel immunosuppressive agents, pig kidney graft survival has increased from minutes to months, and even to >1 year in some cases. Aspects of the selection of the patients for a first clinical trial are discussed. Although there would appear to be some cross-reactivity between anti-human leukocyte antigen (HLA) antibodies and swine leukocyte antigens expressed in pigs, some HLA-sensitized patients will be at no disadvantage if they receive a pig kidney. Furthermore, the current limited evidence is that, even if the patient becomes sensitized to pig antigens (after a pig organ transplant), this would not be detrimental to a subsequent allotransplant. The potential risk of infection with a pig microorganism, and the function of a pig kidney in a primate are also discussed. Key Message: The recent encouraging results of pig kidney transplantation in nonhuman primates suggest the likelihood of a successful (and safe) initial clinical trial, with graft survival for months or possibly years.

scholarly journals Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts

2017 ◽  
Vol 24 (2) ◽  
pp. e12293 ◽  
Author(s):  
Hayato Iwase ◽  
Hidetaka Hara ◽  
Mohamed Ezzelarab ◽  
Tao Li ◽  
Zhongqiang Zhang ◽  
...  
Keyword(s):  
Genetically Engineered ◽  
Pig Kidney

Twenty-Two Cases of Simultaneous Heart, Liver, and Kidney Transplantation From Brain Dead Patients

1998 ◽  
Vol 30 (3) ◽  
pp. 773-774 ◽  
Author(s):  
M. Taheri ◽  
M.H. Mandegar ◽  
Z. Hossein Khan ◽  
G. Pourmand
Keyword(s):  
Kidney Transplantation ◽  
Liver And Kidney ◽  
Brain Dead

Kidney Transplantation from Non-Heart-Beating Donors (NHBD) after Extracorporeal Membranous Oxygenation (ECMO) – initial experience and comparison to brain-dead donors (BDD) outcomes

2018 ◽  
Vol 102 ◽  
pp. S158
Author(s):  
Margarida Manso ◽  
Luís Pacheco-Figueiredo ◽  
André Santos-Silva ◽  
Tiago Antunes-Lopes ◽  
Hugo Diniz ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Initial Experience ◽  
Heart Beating ◽  
Brain Dead

scholarly journals Urinary Biomarkers α-GST and π-GST for Evaluation and Monitoring in Living and Deceased Donor Kidney Grafts

2019 ◽  
Vol 8 (11) ◽  
pp. 1899 ◽  
Author(s):  
Shadi Katou ◽  
Brigitta Globke ◽  
M. Haluk Morgul ◽  
Thomas Vogel ◽  
Benjamin Struecker ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Graft Function ◽  
Rejection Sensitivity ◽  
Deceased Donor ◽  
Urine Samples ◽  
Kidney Graft ◽  
Donor Kidney ◽  
Kidney Recipients ◽  
Deceased Donor Kidney ◽  
Brain Dead

The aim of this study was to analyze the value of urine α- and π-GST in monitoring and predicting kidney graft function following transplantation. In addition, urine samples from corresponding organ donors was analyzed and compared with graft function after organ donation from brain-dead and living donors. Urine samples from brain-dead (n = 30) and living related (n = 50) donors and their corresponding recipients were analyzed before and after kidney transplantation. Urine α- and π-GST values were measured. Kidney recipients were grouped into patients with acute graft rejection (AGR), calcineurin inhibitor toxicity (CNI), and delayed graft function (DGF), and compared to those with unimpaired graft function. Urinary π-GST revealed significant differences in deceased kidney donor recipients with episodes of AGR or DGF at day one after transplantation (p = 0.0023 and p = 0.036, respectively). High π-GST values at postoperative day 1 (cutoff: >21.4 ng/mg urine creatinine (uCrea) or >18.3 ng/mg uCrea for AGR or DGF, respectively) distinguished between rejection and no rejection (sensitivity, 100%; specificity, 66.6%) as well as between DGF and normal-functioning grafts (sensitivity, 100%; specificity, 62.6%). In living donor recipients, urine levels of α- and π-GST were about 10 times lower than in deceased donor recipients. In deceased donors with impaired graft function in corresponding recipients, urinary α- and π-GST were elevated. α-GST values >33.97 ng/mg uCrea were indicative of AGR with a sensitivity and specificity of 77.7% and 100%, respectively. In deceased donor kidney transplantation, evaluation of urinary α- and π-GST seems to predict different events that deteriorate graft function. To elucidate the potential advantages of such biomarkers, further analysis is warranted.

Kidney Transplantation From Brain-Dead Donors: Initial Experience in China

2016 ◽  
Vol 48 (8) ◽  
pp. 2592-2595 ◽  
Author(s):  
Y. Li ◽  
J. Li ◽  
Q. Fu ◽  
L. Chen ◽  
J. Fei ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Initial Experience ◽  
Brain Dead

Effect of Vasoactive Therapy Used for Brain-Dead Donors on Graft Survival After Kidney Transplantation

2018 ◽  
Vol 50 (5) ◽  
pp. 1289-1291 ◽  
Author(s):  
D. Birtan ◽  
M.K. Arslantas ◽  
G.T. Altun ◽  
P.C. Dincer ◽  
S. Gecegormez ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Graft Survival ◽  
Brain Dead

Outcome of Kidney Transplantation Using Organs From Brain-dead Donors Older Than 75 Years

2020 ◽  
Vol 52 (1) ◽  
pp. 119-126
Author(s):  
Louisa Sarah Quast ◽  
Sascha Grzella ◽  
Thorsten Lengenfeld ◽  
Nina Pillokeit ◽  
Marielle Hummels ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Brain Dead

scholarly journals PERIOPERATIVE USE OF BLOOD COMPONENTS DURING HEART, LUNG AND PANCREAS-KIDNEY TRANSPLANTATION FROM BRAIN-DEAD DONORS

2004 ◽  
Vol 50 (5) ◽  
pp. 699-703 ◽  
Author(s):  
Tomoko Kiyokawa ◽  
Machiko Oshida ◽  
Keisuke Nagamine ◽  
Satoru Hayashi ◽  
Yoshiyuki Kurata
Keyword(s):  
Kidney Transplantation ◽  
Blood Components ◽  
Brain Dead ◽  
Pancreas Kidney Transplantation

Successful Kidney Transplantation from a Brain-Dead Donor with Ornithine Transcarbamylase Deficiency

2013 ◽  
Vol 96 (8) ◽  
pp. e63-e64 ◽  
Author(s):  
Francisco Caballero ◽  
Josep Ris ◽  
Mireia Puig ◽  
Jesús Leal ◽  
Salvador Benito
Keyword(s):  
Kidney Transplantation ◽  
Ornithine Transcarbamylase ◽  
Ornithine Transcarbamylase Deficiency ◽  
Brain Dead ◽  
Brain Dead Donor
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