scholarly journals GluN3A NMDA receptor subunits: more enigmatic than ever?

2021 ◽  
Author(s):  
Oliver Crawley ◽  
María J. Conde‐Dusman ◽  
Isabel Pérez‐Otaño
Keyword(s):  
Nmda Receptor ◽  
Nmda Receptor Subunits

scholarly journals Developmental up-regulation of NMDA receptors in the prefrontal cortex and hippocampus of mGlu5 receptor knock-out mice

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Tiziana Imbriglio ◽  
Remy Verhaeghe ◽  
Nico Antenucci ◽  
Stefania Maccari ◽  
Giuseppe Battaglia ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nmda Receptor ◽  
Metabotropic Glutamate Receptors ◽  
Adult Life ◽  
Developmental Time ◽  
Postnatal Life ◽  
Developmental Studies ◽  
Knock Out ◽  
Nmda Receptor Subunits ◽  
The Impact

AbstractmGlu5 metabotropic glutamate receptors are highly expressed and functional in the early postnatal life, and are known to positively modulate NMDA receptor function. Here, we examined the expression of NMDA receptor subunits and interneuron-related genes in the prefrontal cortex and hippocampus of mGlu5−/− mice and wild-type littermates at three developmental time points (PND9, − 21, and − 75). We were surprised to find that expression of all NMDA receptor subunits was greatly enhanced in mGlu5−/− mice at PND21. In contrast, at PND9, expression of the GluN2B subunit was enhanced, whereas expression of GluN2A and GluN2D subunits was reduced in both regions. These modifications were transient and disappeared in the adult life (PND75). Changes in the transcripts of interneuron-related genes (encoding parvalbumin, somatostatin, vasoactive intestinal peptide, reelin, and the two isoforms of glutamate decarboxylase) were also observed in mGlu5−/− mice across postnatal development. For example, the transcript encoding parvalbumin was up-regulated in the prefrontal cortex of mGlu5−/− mice at PND9 and PND21, whereas it was significantly reduced at PND75. These findings suggest that in mGlu5−/− mice a transient overexpression of NMDA receptor subunits may compensate for the lack of the NMDA receptor partner, mGlu5. Interestingly, in mGlu5−/− mice the behavioral response to the NMDA channel blocker, MK-801, was significantly increased at PND21, and largely reduced at PND75. The impact of adaptive changes in the expression of NMDA receptor subunits should be taken into account when mGlu5−/− mice are used for developmental studies.

scholarly journals Biochemical and electrophysiological characterization of N- glycans on NMDA receptor subunits

2016 ◽  
Vol 138 (4) ◽  
pp. 546-556 ◽  
Author(s):  
Martina Kaniakova ◽  
Katarina Lichnerova ◽  
Kristyna Skrenkova ◽  
Ladislav Vyklicky ◽  
Martin Horak
Keyword(s):  
Nmda Receptor ◽  
Nmda Receptor Subunits ◽  
Electrophysiological Characterization

scholarly journals Corrigendum: Chronic MK-801 Application in Adolescence and Early Adulthood: A Spatial Working Memory Deficit in Adult Long-Evans Rats But No Changes in the Hippocampal NMDA Receptor Subunits

2018 ◽  
Vol 9 ◽  
Author(s):  
Libor Uttl ◽  
Tomas Petrasek ◽  
Hilal Sengul ◽  
Marketa Svojanovska ◽  
Veronika Lobellova ◽  
...  
Keyword(s):  
Working Memory ◽  
Nmda Receptor ◽  
Spatial Working Memory ◽  
Early Adulthood ◽  
Memory Deficit ◽  
Mk 801 ◽  
Nmda Receptor Subunits ◽  
Long Evans

Glutamic acid reverses Pb2+-induced reductions of NMDA receptor subunits in vitro

2006 ◽  
Vol 27 (2) ◽  
pp. 169-175 ◽  
Author(s):  
Shang-Zhi Xu ◽  
Bettaiya Rajanna
Keyword(s):  
Nmda Receptor ◽  
Glutamic Acid ◽  
Nmda Receptor Subunits

103 Distinct laminar distribution of NMDA receptor subunits in the mouse hippocampus

1997 ◽  
Vol 28 ◽  
pp. S19
Author(s):  
Masahiko Watanabe ◽  
Kenji Sakimura ◽  
Masayoshi Mishina ◽  
Yoshiro Inoue
Keyword(s):  
Nmda Receptor ◽  
Nmda Receptor Subunits ◽  
Laminar Distribution ◽  
Mouse Hippocampus

Mass Spectrometrical Identification of Hippocampal NMDA Receptor Subunits NR1, NR2A–D and Five Novel Phosphorylation Sites on NR2A and NR2B

2012 ◽  
Vol 11 (3) ◽  
pp. 1891-1896 ◽  
Author(s):  
Maryam Ghafari ◽  
Harald Höger ◽  
Soheil Keihan Falsafi ◽  
Nina Russo-Schlaff ◽  
Arnold Pollak ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Phosphorylation Sites ◽  
Nmda Receptor Subunits

scholarly journals Do specific NMDA receptor subunits act as gateways for addictive behaviors?

2016 ◽  
Vol 16 (1) ◽  
pp. 118-138 ◽  
Author(s):  
F. W. Hopf
Keyword(s):  
Nmda Receptor ◽  
Addictive Behaviors ◽  
Nmda Receptor Subunits

Synaptic localization of NMDA receptor subunits in the rat retina

2000 ◽  
Vol 420 (1) ◽  
pp. 98-112 ◽  
Author(s):  
Erica L. Fletcher ◽  
Iris Hack ◽  
Johann Helmut Brandst�tter ◽  
Heinz W�ssle
Keyword(s):  
Nmda Receptor ◽  
Synaptic Localization ◽  
Rat Retina ◽  
Nmda Receptor Subunits

scholarly journals Expression of AMPA, kainate, and NMDA receptor subunits in cochlear and vestibular ganglia

1995 ◽  
Vol 15 (3) ◽  
pp. 2338-2353 ◽  
Author(s):  
AS Niedzielski ◽  
RJ Wenthold
Keyword(s):  
Nmda Receptor ◽  
Nmda Receptor Subunits
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