Uncovering variability in children's concepts and conceptual change

Capturing the structure and development of human conceptual knowledge is a challenging but fundamental task in Cognitive Science. The most prominent approach to uncovering these concepts is Multidimensional scaling (MDS), which has provided insight into the structure of human perception and conceptual knowledge. However, MDS usually requires participants to produce large numbers of similarity judgments, leading to prohibitively long experiments for most developmental research. Furthermore, MDS provides a single psychological space, tailored to a fixed set of stimuli. In contrast, we present a method that learns psychological spaces flexibly and generalizes to novel stimuli. In addition, our approach uses a simple, developmentally appropriate task, which allows for short and engaging developmental studies. We evaluate the feasibility of our approach on simulated data and find that it can uncover the true structure even when the data consists of aggregations of diverse categorizers. We then apply the method to data from the World Color Survey and find that it can discover language-specific color organization. Finally, we use the method in a novel developmental experiment and find age-dependent differences in conceptual spaces for fruit categories. These results suggest that our method is robust and widely applicable in developmental tasks with children as young as four years old.

Development and Evolution of Unisexual Flowers: A Review

The development of unisexual flowers has been described in a large number of taxa, sampling the diversity of floral phenotypes and sexual systems observed in extant angiosperms, in studies focusing on floral ontogeny, on the evo-devo of unisexuality, or on the genetic and chromosomal bases of unisexuality. We review here such developmental studies, aiming at characterizing the diversity of ontogenic pathways leading to functionally unisexual flowers. In addition, we present for the first time and in a two-dimensional morphospace a quantitative description of the developmental rate of the sexual organs in functionally unisexual flowers, in a non-exhaustive sampling of angiosperms with contrasted floral morphologies. Eventually, recommendations are provided to help plant evo-devo researchers and botanists addressing macroevolutionary and ecological issues to more precisely select the taxa, the biological material, or the developmental stages to be investigated.

The Capability Approach in Social Work with Older People

This chapter reports the findings from a scoping review of the use of the capability approach in social work with older people. Four peer-reviewed articles using the capability approach and addressing social work practice with older people are discussed. The purpose was to examine how the use of the capability approach is linked to policies, practices and social justice approaches in social work research. Two main applications of the capability approach were found: to explore the subjective sense of well-being, and to address social inequalities at a structural level. The capability approach was framed as congruent with the aims of social work, and as a call for action for social workers to promote social justice, human dignity and well-being. Only a few studies were found in this scoping review; however, more seemed to have been done within the fields of healthcare and developmental studies. Despite these limitations, the conclusion is that the capability approach has attracted some attention in social work with older people, and the number of studies elaborating on the capability approach in social work in general is growing.

Nanoencapsulated Myricetin to Improve Antioxidant Activity and Bioavailability: A Study on Zebrafish Embryos

Flavonoids are natural polyphenolic compounds that mainly possess antioxidant properties due to more hydroxyl groups in their structure and play an important role in combatting many diseases. Myricetin is a flavonoid found in grapes, green tea, fruits, and vegetables and is not only an antioxidant but also is a pro-oxidant. Myricetin is sparingly soluble in water and restricts its properties due to low bioavailability. The present study reports the liposomal nanoformulations of myricetin to improve its bioavailability with reduced pro-oxidant activity. The nanoformulated myricetin was characterized using different photophysical tools, such as dynamic light scattering (DLS), zeta potential, and scanning electron microscopy (SEM). The effect of nanoencapsulated myricetin on the developing zebrafish embryo was studied in terms of microscopic observations, cumulative hatchability, and antioxidant activities, such as catalase, glutathione peroxidase, and superoxide dismutase, after treating the zebrafish embryo with standard oxidant hydrogen peroxide. The results obtained from the cumulative hatchability, developmental studies, and antioxidant assays indicated that the liposomal nanoformulation of myricetin had enhanced antioxidant activity, leading to defense against oxidative stress. The formulation was highly biocompatible, as evidenced by the cumulative hatching studies as well as microscopic observations. The positive effects of liposomal nanoformulation on zebrafish embryos can open an avenue for other researchers to carry out further related research and to check its activities in clinical studies and developmental studies.

AdpA Positively Regulates Morphological Differentiation and Chloramphenicol Biosynthesis in Streptomyces venezuelae

Streptomyces are well-known producers of valuable secondary metabolites which include a large variety of antibiotics and important model organisms for developmental studies in multicellular bacteria. The conserved transcriptional regulator AdpA of Streptomyces exerts a pleiotropic effect on cellular processes, including the morphological differentiation and biosynthesis of secondary metabolites.

The effect of selective discussion on young people's autobiographical memories

<p>Young people frequently talk about memories of experienced events with their parents and peers. These conversations are selective and little is known about the fate of memories that are not talked about. Retrieval-induced forgetting (RIF; Anderson, Bjork, & Bjork, 1994) is an experimental paradigm that can be used as a proxy for selective conversations under controlled conditions. While some studies have been conducted with adults (see Storm et al., 2015 for review), the impact of selective discussion on young people’s recall of their autobiographical memories has not yet been investigated. This thesis, therefore, addresses a number of key gaps in the literature. In the first study, we investigated the impact of selective discussion on 8-9-year-old children’s (N = 65) recall of their autobiographical memories. Selective discussion produced RIF for children’s positive and negative memories. Selective discussion also produced RIF for children’s memory details; even when non-discussed memories were recalled, they were recalled in sparser detail. In addition, children who discussed a selection of their memories in more detail later forgot a greater proportion of their non-discussed memories. These findings are the first to demonstrate that selective discussion with children results in non-discussed memories being forgotten. Moreover, the findings indicate the importance of memory detail in RIF for autobiographical memories. In the second study, we investigated the short and long-term impact of selective discussion on 13-15-year-old adolescents’ (N = 58) recall of their autobiographical memories. After a short delay, selective discussion led to RIF for adolescents’ negative memories only; RIF did not occur for adolescents’ positive memories. After a long delay, RIF occurred for both positive and negative autobiographical memories. Given that Study 1 demonstrated that for children, RIF occurred for both positive and negative memories after a short delay, these findings with adolescents represent a novel developmental difference in RIF for autobiographical memories with regard to memory valence. In addition, they suggest that RIF for different kinds of stimuli may occur over different delay periods. In the third study, we expanded on the findings of Study 1, investigating the impact of selective discussion on specific kinds of autobiographical memory details for both children and adolescents (N = 123; combined sample from Study 1 and 2). RIF occurred for some memory details but did not occur for others. Moreover, the details of children’s, as compared to adolescents’, non-discussed autobiographical memories were more vulnerable to being forgotten following selective discussion. These findings again demonstrate a developmental difference in RIF for autobiographical memories and highlight the importance of investigating how selective discussion may impair non-discussed autobiographical memories even when they are recalled. Overall, our findings extend the field by establishing that selective discussion about young people’s everyday autobiographical memories results in non-discussed memories being forgotten. More specifically, we found developmental differences with regard to memory valence and detail that had previously been overlooked in developmental studies of RIF. Our findings add clarity about the specific types of memory detail that are vulnerable to being forgotten from non-discussed memories and highlight the necessity of investigating the long-term effects of selective discussion, even when RIF is not immediately evident.</p>

The effect of selective discussion on young people's autobiographical memories

<p>Young people frequently talk about memories of experienced events with their parents and peers. These conversations are selective and little is known about the fate of memories that are not talked about. Retrieval-induced forgetting (RIF; Anderson, Bjork, & Bjork, 1994) is an experimental paradigm that can be used as a proxy for selective conversations under controlled conditions. While some studies have been conducted with adults (see Storm et al., 2015 for review), the impact of selective discussion on young people’s recall of their autobiographical memories has not yet been investigated. This thesis, therefore, addresses a number of key gaps in the literature. In the first study, we investigated the impact of selective discussion on 8-9-year-old children’s (N = 65) recall of their autobiographical memories. Selective discussion produced RIF for children’s positive and negative memories. Selective discussion also produced RIF for children’s memory details; even when non-discussed memories were recalled, they were recalled in sparser detail. In addition, children who discussed a selection of their memories in more detail later forgot a greater proportion of their non-discussed memories. These findings are the first to demonstrate that selective discussion with children results in non-discussed memories being forgotten. Moreover, the findings indicate the importance of memory detail in RIF for autobiographical memories. In the second study, we investigated the short and long-term impact of selective discussion on 13-15-year-old adolescents’ (N = 58) recall of their autobiographical memories. After a short delay, selective discussion led to RIF for adolescents’ negative memories only; RIF did not occur for adolescents’ positive memories. After a long delay, RIF occurred for both positive and negative autobiographical memories. Given that Study 1 demonstrated that for children, RIF occurred for both positive and negative memories after a short delay, these findings with adolescents represent a novel developmental difference in RIF for autobiographical memories with regard to memory valence. In addition, they suggest that RIF for different kinds of stimuli may occur over different delay periods. In the third study, we expanded on the findings of Study 1, investigating the impact of selective discussion on specific kinds of autobiographical memory details for both children and adolescents (N = 123; combined sample from Study 1 and 2). RIF occurred for some memory details but did not occur for others. Moreover, the details of children’s, as compared to adolescents’, non-discussed autobiographical memories were more vulnerable to being forgotten following selective discussion. These findings again demonstrate a developmental difference in RIF for autobiographical memories and highlight the importance of investigating how selective discussion may impair non-discussed autobiographical memories even when they are recalled. Overall, our findings extend the field by establishing that selective discussion about young people’s everyday autobiographical memories results in non-discussed memories being forgotten. More specifically, we found developmental differences with regard to memory valence and detail that had previously been overlooked in developmental studies of RIF. Our findings add clarity about the specific types of memory detail that are vulnerable to being forgotten from non-discussed memories and highlight the necessity of investigating the long-term effects of selective discussion, even when RIF is not immediately evident.</p>

A Review of Prostate Organogenesis and a Role for iPSC-Derived Prostate Organoids to Study Prostate Development and Disease

The prostate is vulnerable to two major age-associated diseases, cancer and benign enlargement, which account for significant morbidity and mortality for men across the globe. Prostate cancer is the most common cancer reported in men, with over 1.2 million new cases diagnosed and 350,000 deaths recorded annually worldwide. Benign prostatic hyperplasia (BPH), characterised by the continuous enlargement of the adult prostate, symptomatically afflicts around 50% of men worldwide. A better understanding of the biological processes underpinning these diseases is needed to generate new treatment approaches. Developmental studies of the prostate have shed some light on the processes essential for prostate organogenesis, with many of these up- or downregulated genes expressions also observed in prostate cancer and/or BPH progression. These insights into human disease have been inferred through comparative biological studies relying primarily on rodent models. However, directly observing mechanisms of human prostate development has been more challenging due to limitations in accessing human foetal material. Induced pluripotent stem cells (iPSCs) could provide a suitable alternative as they can mimic embryonic cells, and iPSC-derived prostate organoids present a significant opportunity to study early human prostate developmental processes. In this review, we discuss the current understanding of prostate development and its relevance to prostate-associated diseases. Additionally, we detail the potential of iPSC-derived prostate organoids for studying human prostate development and disease.

A checklist of halacarid and hydrachnid mites (Acari, Halacaridae & Hydrachnidia) associated with sponges (Porifera)

A compilation of halacarid and hydrachnid mite species found associated with sponges has been carried out based on published records. Altogether 78 halacarid mites species belonging to 15 genera viz. Agaue (9 species), Agauopsis (7 species), Arhodeoporus (1 species), Atelopsalis (1 species), Bradyagaue (1 species), Copidognathus (27 species), Halacarellus (7 species), Halacaropsis (2 species), Halacarus (5 species), Lohmannella (3 species), Maracarus (3 species), Rhombognathides (3 species), Rhombognathus (4 species), Spongihalacarus (1 species), and Thalassarachna (4 species) are reported. Twenty-four hydrachnid mite species belonging to three families viz. Hygrobatidae (2 species), Unionicolidae (20 species) and Pontarachnidae (2 species) are included. Some species of Unionicolidae are mentioned as possible sponge-mite species. Further studies, emphasizing developmental studies of unionicolid mites to get better ideas about associations with freshwater sponges are needed. Molecular sequencing will reveal more cryptic species and improve the quality of re-descriptions of currently recognized species in these sponge associated mites.