scholarly journals Nitric oxide synthase inhibition affects sarcoplasmic reticulum Ca2+release in skeletal muscle fibres from mouse

2005 ◽  
Vol 567 (3) ◽  
pp. 815-828 ◽  
Author(s):  
Sandrine Pouvreau ◽  
Vincent Jacquemond
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Sarcoplasmic Reticulum ◽  
Nitric Oxide Synthase ◽  
Muscle Fibres ◽  
Oxide Synthase ◽  
Skeletal Muscle Fibres

scholarly journals Nitric oxide synthase in skeletal muscle fibres of patients with type 2 diabetes

2012 ◽  
Author(s):  
Karla Punkt ◽  
Katharina Kandt ◽  
Andreas Oberbach ◽  
Volker Adams ◽  
Igor Buchwalow ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Nitric Oxide Synthase ◽  
Muscle Fibres ◽  
Oxide Synthase ◽  
Skeletal Muscle Fibres

scholarly journals Endothelial Nitric Oxide Synthase Expression in the Sarcoplasmic Reticulum of Mouse Skeletal Muscle

2004 ◽  
Vol 37 (5) ◽  
pp. 307-311 ◽  
Author(s):  
Kyutaro Kawagishi ◽  
Fumiko Terasawa ◽  
Akinori Nakamura ◽  
Tetsuji Moriizumi ◽  
Hideho Ueda
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Sarcoplasmic Reticulum ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Mouse Skeletal Muscle ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Expression of nitric oxide synthase in skeletal muscle: a novel role for nitric oxide as a modulator of insulin action

Diabetes ◽  
1997 ◽  
Vol 46 (11) ◽  
pp. 1691-1700 ◽  
Author(s):  
S. Kapur ◽  
S. Bedard ◽  
B. Marcotte ◽  
C. H. Cote ◽  
A. Marette
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Nitric Oxide Synthase ◽  
Insulin Action ◽  
Oxide Synthase

Nitric oxide synthase-dependent “On/Off” switch and apoptosis in freshwater and aestivating lungfish, Protopterus annectens: Skeletal muscle versus cardiac muscle

Nitric Oxide ◽  
2013 ◽  
Vol 32 ◽  
pp. 1-12 ◽  
Author(s):  
D. Amelio ◽  
F. Garofalo ◽  
W.P. Wong ◽  
S.F. Chew ◽  
Y.K. Ip ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Nitric Oxide Synthase ◽  
Cardiac Muscle ◽  
Protopterus Annectens ◽  
Oxide Synthase

Glucose uptake during contraction in isolated skeletal muscles from neuronal nitric oxide synthase μ knockout mice

2015 ◽  
Vol 118 (9) ◽  
pp. 1113-1121 ◽  
Author(s):  
Yet Hoi Hong ◽  
Tony Frugier ◽  
Xinmei Zhang ◽  
Robyn M. Murphy ◽  
Gordon S. Lynch ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Nitric Oxide Synthase ◽  
Glucose Uptake ◽  
Ex Vivo ◽  
Organ Bath ◽  
Skeletal Muscle Glucose Uptake ◽  
Nos Inhibitor ◽  
Amp Activated Protein Kinase ◽  
Oxide Synthase

Inhibition of nitric oxide synthase (NOS) significantly attenuates the increase in skeletal muscle glucose uptake during contraction/exercise, and a greater attenuation is observed in individuals with Type 2 diabetes compared with healthy individuals. Therefore, NO appears to play an important role in mediating muscle glucose uptake during contraction. In this study, we investigated the involvement of neuronal NOSμ (nNOSμ), the main NOS isoform activated during contraction, on skeletal muscle glucose uptake during ex vivo contraction. Extensor digitorum longus muscles were isolated from nNOSμ−/−and nNOSμ+/+mice. Muscles were contracted ex vivo in a temperature-controlled (30°C) organ bath with or without the presence of the NOS inhibitor NG-monomethyl-l-arginine (L-NMMA) and the NOS substrate L-arginine. Glucose uptake was determined by radioactive tracers. Skeletal muscle glucose uptake increased approximately fourfold during contraction in muscles from both nNOSμ−/−and nNOSμ+/+mice. L-NMMA significantly attenuated the increase in muscle glucose uptake during contraction in both genotypes. This attenuation was reversed by L-arginine, suggesting that L-NMMA attenuated the increase in muscle glucose uptake during contraction by inhibiting NOS and not via a nonspecific effect of the inhibitor. Low levels of NOS activity (∼4%) were detected in muscles from nNOSμ−/−mice, and there was no evidence of compensation from other NOS isoform or AMP-activated protein kinase which is also involved in mediating muscle glucose uptake during contraction. These results indicate that NO regulates skeletal muscle glucose uptake during ex vivo contraction independently of nNOSμ.

scholarly journals Isoproterenol-Enhanced Diastolic Sarcoplasmic Reticulum Ca Leak in Ventricular Myocytes Requires Activation of Nitric Oxide Synthase

2009 ◽  
Vol 96 (3) ◽  
pp. 120a-121a ◽  
Author(s):  
Jerry Curran ◽  
Usama Ahmed ◽  
Donald M. Bers ◽  
Mark Ziolo ◽  
Thomas R. Shannon
Keyword(s):  
Nitric Oxide ◽  
Sarcoplasmic Reticulum ◽  
Nitric Oxide Synthase ◽  
Ventricular Myocytes ◽  
Oxide Synthase
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