Role of Cellular Orientation in Electrical Coupling Between Gastrointestinal Smooth Muscle

10.1114/1.45 ◽  
1998 ◽  
Vol 26 (4) ◽  
pp. 703-711 ◽  
Author(s):  
Edward J. Vigmond ◽  
Berj L. Bardakjian
Keyword(s):  
Smooth Muscle ◽  
Electrical Coupling ◽  
Gastrointestinal Smooth Muscle

Contractile role of M2 and M3 muscarinic receptors in gastrointestinal smooth muscle

Life Sciences ◽  
1999 ◽  
Vol 64 (6-7) ◽  
pp. 387-394 ◽  
Author(s):  
Frederick J. Ehlert ◽  
Gregory W. Sawyer ◽  
Evette E. Esqueda
Keyword(s):  
Smooth Muscle ◽  
Muscarinic Receptors ◽  
Gastrointestinal Smooth Muscle

Teaching a changing paradigm in physiology: a historical perspective on gut interstitial cells

2017 ◽  
Vol 41 (1) ◽  
pp. 100-109 ◽  
Author(s):  
Bernard T. Drumm ◽  
Salah A. Baker
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Historical Perspective ◽  
New Technologies ◽  
Electrical Coupling ◽  
Muscle Cells ◽  
Interstitial Cells ◽  
Enteric Neurons ◽  
Gi Motility

The study and teaching of gastrointestinal (GI) physiology necessitates an understanding of the cellular basis of contractile and electrical coupling behaviors in the muscle layers that comprise the gut wall. Our knowledge of the cellular origin of GI motility has drastically changed over the last 100 yr. While the pacing and coordination of GI contraction was once thought to be solely attributable to smooth muscle cells, it is now widely accepted that the motility patterns observed in the GI tract exist as a result of a multicellular system, consisting of not only smooth muscle cells but also enteric neurons and distinct populations of specialized interstitial cells that all work in concert to ensure proper GI functions. In this historical perspective, we focus on the emerging role of interstitial cells in GI motility and examine the key discoveries and experiments that led to a major shift in a paradigm of GI physiology regarding the role of interstitial cells in modulating GI contractile patterns. A review of these now classic experiments and papers will enable students and educators to fully appreciate the complex, multicellular nature of GI muscles as well as impart lessons on how shifting paradigms in physiology are fueled by new technologies that lead to new emerging discoveries.

scholarly journals Role of PI3-kinase in the development of interstitial cells and pacemaking in murine gastrointestinal smooth muscle

1999 ◽  
Vol 516 (3) ◽  
pp. 835-846 ◽  
Author(s):  
Sean M. Ward ◽  
Mary-Frances Brennan ◽  
Vivienne M. Jackson ◽  
Kenton M. Sanders
Keyword(s):  
Smooth Muscle ◽  
Interstitial Cells ◽  
Pi3 Kinase ◽  
Gastrointestinal Smooth Muscle

The role of Na+/Ca2+ exchanger in opossum esophageal smooth muscle contractillty

2001 ◽  
Vol 120 (5) ◽  
pp. A57-A57 ◽  
Author(s):  
P ROY ◽  
Y ZHANG ◽  
S LORENSSEN ◽  
M BLENNERHASETT ◽  
W PATERSON
Keyword(s):  
Smooth Muscle

Role of stat6 in hypercontractility of murine small intestinal smooth muscle induced by nematode infection

2001 ◽  
Vol 120 (5) ◽  
pp. A534-A534
Author(s):  
A ZHAO ◽  
D MULLOY ◽  
J URBANJR ◽  
W GAUSE ◽  
T SHEADONOHUE
Keyword(s):  
Smooth Muscle ◽  
Nematode Infection ◽  
Intestinal Smooth Muscle ◽  
Small Intestinal
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